PDB ID 2GZH     CHAIN A
Protein name Ras-related protein Rab-11A
Uniprot Accession P62491
The number of similar proteins 25
The number of binding states 11
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2GZH (CHAIN: A)
1 Q7L804  
2 Monomeric state
3 O60239  
4 Q9ULV0  
5 1OIV  
6 Q96QF0  
7 O75154  
8 Q64595  
9 Q7L804   Q7L804  
10 O75154   Q96QF0  
11 O75154   O75154   Q96QF0  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MGTRDDEYDY   LFKVVLIGDS   GVGKSNLLSR   FTRNEFNLES   KSTIGVEFAT   50
51   RSIQVDGKTI   KAQIWDTAGL   ERYRAITSAY   YRGAVGALLV   YDIAKHLTYE   100
101   NVERWLKELR   DHADSNIVIX   LVGNKSDLRH   LRAVPTDEAR   AFAEKNGLSF   150
151   IETSALDSTN   VEAAFQTILT   EIY       200

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
22_VAL MET ClinVar
chr19:8464770
rs1555690779
Pathogenic/Likely pathogenic - Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter [MONDO:MONDO:0060624,MedGen:C4540498,OMIM:617807]
68_ALA THR ClinVar
chr19:8464908
rs1555690804
Pathogenic/Likely pathogenic - Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter|not provided [MONDO:MONDO:0060624,MedGen:C4540498,OMIM:617807|MedGen:C3661900]
102_VAL MET 8.3kJPN
chr19:8467037
rs1437902263
- 0.0001 -
110_ARG TRP 8.3kJPN
chr19:8467061
rs776189936
- 0.0013 -
112_HIS ARG ClinVar
chr15:66170198
-
Likely pathogenic - 7 conditions [7 conditions]
120_MET VAL 8.3kJPN
chr15:66170221
-
- 0.0001 -
120_MET ILE 8.3kJPN
chr19:8467093
-
- 0.0001 -
154_SER LEU ClinVar
chr15:66172039
-
Pathogenic/Likely pathogenic - not provided [MedGen:C3661900]
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.