PDB ID 2H3D     CHAIN A
Protein name Nicotinamide phosphoribosyltransferase
Uniprot Accession Q99KQ4
The number of similar proteins 175
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2H3D (CHAIN: A)
1 Q99KQ4  
2 Monomeric state

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   GSHXNAAAEA   EFNILLATDS   YKVTHYKQYP   PNTSKVYSYF   ECREKKTENS   50
51   KVRKVKYEET   VFYGLQYILN   KYLKGKVVTK   EKIQEAKEVY   REHFQDDVFN   100
101   ERGWNYILEK   YDGHLPIEVK   AVPEGSVIPR   GNVLFTVENT   DPECYWLTNW   150
151   IETILVQSWY   PITVATNSRE   QKKILAKYLL   ETSGNLDGLE   YKLHDFGYRG   200
201   VSSQETAGIG   ASAHLVNFKG   TDTVAGIALI   KKYYGTKDPV   PGYSVPAAEH   250
251   STITAWGKDH   EKDAFEHIVT   QFSSVPVSVV   SDSYDIYNAC   EKIWGEDLRH   300
301   LIVSRSTEAP   LIIRPDSGNP   LDTVLKVLDI   LGKKFPVTEN   SKGYKLLPPY   350
351   LRVIQGDGVD   INTLQEIVEG   XKQKKWSIEN   VSFGSGGALL   QKLTRDLLNC   400
401   SFKCSYVVTN   GLGVNVFKDP   VADPNKRSKK   GRLSLHRTPA   GNFVTLEEGK   450
451   GDLEEYGHDL   LHTVFKNGKV   TKSYSFDEVR   KNAQLNIEQD   VAPH   500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
11_ILE VAL 8.3kJPN
chr7:105925300 		rs1209577193
- 0.0001 -
84_LYS ARG 8.3kJPN
chr7:105915459 		rs1361672762
- 0.0001 -
95_VAL ALA 8.3kJPN
chr7:105915426 		-
- 0.0001 -
204_ALA GLY 8.3kJPN
chr7:105909042 		-
- 0.0001 -
226_LEU VAL 8.3kJPN
chr7:105908977 		rs1421696802
- 0.0001 -
260_ASP ASN 8.3kJPN
chr7:105904029 		rs1282405793
- 0.0002 -
440_PHE CYS 8.3kJPN
chr7:105893509 		-
- 0.0001 -
453_TYR HIS 8.3kJPN
chr7:105893471 		-
- 0.0001 -
475_GLU ALA gnomAD
chr7:105891581 		rs140819103
- 0.000143513 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.