PDB ID 2H40     CHAIN A
Protein name cGMP-specific 3',5'-cyclic phosphodiesterase
Uniprot Accession O76074
The number of similar proteins 41
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2H40 (CHAIN: A)
1 Monomeric state
2 O76074  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   EETRELQSLA   AAVVPSAQTL   KITDFSFSDF   ELSDLETALC   TIRMFTDLNL   50
51   VQNFQMKHEV   LCRWILSVKK   NYRKNVAYHN   WRHAFNTAQC   MFAALKAGKI   100
101   QNKLTDLEIL   ALLIAALSHD   LDHRGVNNSY   IQRSEHPLAQ   LYCHSIMEHH   150
151   HFDQCLMILN   SPGNQILSGL   SIEEYKTTLK   IIKQAILATD   LALYIKRRGE   200
201   FFELIRKNQF   NLEDPHQKEL   FLAMLMTACD   LSAITKPWPI   QQRIAELVAT   250
251   EFFDQGDRER   KELNIEPTDL   MNREKKNKIP   SMQVGFIDAI   CLQLYEALTH   300
301   VSEDCFPLLD   GCRKNRQKWQ   ALAEQQ       350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
562_SER ASN 8.3kJPN
chr4:120446798 		rs778103038
- 0.0002 -
577_ARG GLN 8.3kJPN
chr4:120446753 		rs569083571
- 0.0004 -
577_ARG TRP 8.3kJPN
chr4:120446754 		rs182361575
- 0.0001 -
625_MET THR gnomAD
chr4:120442121 		rs199872206
- 0.000128247 -
641_LEU PRO gnomAD
chr4:120440278 		rs116396619
- 0.00103949 -
740_ARG LYS gnomAD
chr4:120427058 		rs139979143
- 0.00414276 -
758_MET THR 8.3kJPN
chr4:120425749 		-
- 0.0001 -
777_ARG GLN 8.3kJPN
chr4:120425692 		rs374510132
- 0.0002 -
788_ASP TYR 8.3kJPN
chr4:120423780 		rs201756535
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.