PDB ID | 2H7C | CHAIN | A |
---|---|---|---|
Protein name | Liver carboxylesterase 1 | ||
Uniprot Accession | P23141 | ||
The number of similar proteins | 55 | ||
The number of binding states | 3 | ||
The number of binding partners | 1 |
Unicolor (beige)
The number of binding partners
Group
Binding state |
Binding partners |
---|---|
2H7C (CHAIN: A) | |
1 | P23141 P23141 P23141 |
2 | Monomeric state |
3 | P23141 P23141 |
Only interaction residues |
|
||||||
|
Residue | AA | Source | dbSNP | Clinical Significance |
Allele Frequency (> 0.0001) |
Disease name | |
---|---|---|---|---|---|---|---|
1022_SER | LEU |
8.3kJPN chr16:55862871 |
rs142474691
|
- | 0.0001 | - | |
1032_LYS | ASN |
8.3kJPN chr16:55862840 |
-
|
- | 0.0001 | - | |
1034_LEU | ARG |
gnomAD chr16:55862835 |
rs749254726
|
- | 0.000255814 | - | |
1038_VAL | ILE |
8.3kJPN chr16:55862824 |
rs3826192
|
- | 0.1189 | - | |
1044_ALA | VAL |
gnomAD chr16:55862805 |
rs142469038
|
- | 0.000203111 | - | |
1048_ALA | VAL |
8.3kJPN chr16:55862793 |
-
|
- | 0.0001 | - | |
1049_ILE | VAL |
8.3kJPN chr16:55862791 |
rs3826193
|
- | 0.1027 | - | |
1068_PRO | LEU |
gnomAD chr16:55862733 |
rs757329400
|
- | 0.000123265 | - | |
1068_PRO | SER |
8.3kJPN chr16:55862734 |
rs1158400665
|
- | 0.0001 | - | |
1075_SER | ASN | VAR_014314 |
rs2307240
|
LB/B | - | - | |
1075_SER | ASN |
gnomAD chr16:55862712 |
rs2307240
|
- | 0.0486827 | - | |
1075_SER | ASN |
8.3kJPN chr16:55862712 |
rs2307240
|
- | 0.0425 | - | |
1078_LYS | ARG |
8.3kJPN chr16:55862703 |
rs373547343
|
- | 0.0001 | - | |
1079_ASN | ASP |
8.3kJPN chr16:55862701 |
rs773058212
|
- | 0.0007 | - | |
1082_SER | LEU |
8.3kJPN chr16:55862691 |
rs62028647
|
- | 0.1819 | - | |
1086_MET | VAL |
8.3kJPN chr16:55862680 |
-
|
- | 0.0001 | - | |
1093_ALA | VAL |
gnomAD chr16:55860187 |
rs202111709
|
- | 0.00011546 | - | |
1094_GLY | VAL |
8.3kJPN chr16:55860184 |
-
|
- | 0.0001 | - | |
1101_PHE | LEU |
8.3kJPN chr16:55860162 |
rs750433997
|
- | 0.0001 | - | |
1103_ASN | ASP |
8.3kJPN chr16:55860158 |
-
|
- | 0.0003 | - | |
1124_PRO | SER |
8.3kJPN chr16:55860095 |
-
|
- | 0.0001 | - | |
1141_GLY | ARG |
8.3kJPN chr16:55857577 |
rs778421449
|
- | 0.0001 | - | |
1142_GLY | GLU |
ClinVar chr16:55857573 |
rs121912777
|
Pathogenic | - | DRUG METABOLISM, ALTERED, CES1-RELATED [MedGen:C4748035,OMIM:618057] | |
1142_GLY | VAL |
8.3kJPN chr16:55857573 |
rs121912777
|
- | 0.0002 | - | |
1143_GLY | GLU | VAR_046954 |
rs71647871
|
LB/B | - | - | |
1143_GLY | GLU |
gnomAD chr16:55857570 |
rs71647871
|
- | 0.010918 | - | |
1147_GLY | CYS |
gnomAD chr16:55857559 |
rs146456965
|
- | 0.000433817 | - | |
1148_ALA | VAL |
gnomAD chr16:55857555 |
rs369026668
|
- | 0.000111433 | - | |
1150_SER | PRO |
8.3kJPN chr16:55857550 |
-
|
- | 0.0001 | - | |
1158_ALA | VAL |
gnomAD chr16:55857525 |
rs202121317
|
- | 0.00743687 | - | |
1158_ALA | VAL |
8.3kJPN chr16:55857525 |
rs202121317
|
- | 0.0003 | - | |
1167_THR | SER |
gnomAD chr16:55857498 |
rs147694791
|
- | 0.00344171 | - | |
1167_THR | SER |
8.3kJPN chr16:55857498 |
rs147694791
|
- | 0.0001 | - | |
1173_GLY | ASP |
8.3kJPN chr16:55857480 |
rs4784575
|
- | 0.0622 | - | |
1174_ILE | THR |
gnomAD chr16:55857477 |
rs751365501
|
- | 0.000183397 | - | |
1176_GLY | ARG |
8.3kJPN chr16:55857472 |
-
|
- | 0.0001 | - | |
1179_SER | ASN |
8.3kJPN chr16:55857462 |
-
|
- | 0.0001 | - | |
1186_ARG | PRO |
gnomAD chr16:55855413 |
rs60054861
|
- | 0.0107501 | - | |
1186_ARG | GLN |
gnomAD chr16:55855413 |
rs60054861
|
- | 0.00190317 | - | |
1186_ARG | PRO |
8.3kJPN chr16:55855413 |
rs60054861
|
- | 0.0002 | - | |
1186_ARG | TRP |
8.3kJPN chr16:55855414 |
rs200227274
|
- | 0.0001 | - | |
1190_GLY | CYS |
gnomAD chr16:55855402 |
rs150241462
|
- | 0.000274605 | - | |
1197_ALA | THR |
8.3kJPN chr16:55855381 |
-
|
- | 0.0001 | - | |
1199_ARG | HIS | VAR_014594 |
rs2307243
|
LB/B | - | - | |
1199_ARG | HIS |
gnomAD chr16:55855374 |
rs2307243
|
- | 0.000688305 | - | |
1199_ARG | HIS |
8.3kJPN chr16:55855374 |
rs2307243
|
- | 0.0001 | - | |
1203_ASP | GLU | VAR_014595 |
rs2307227
|
LB/B | - | - | |
1203_ASP | GLU |
gnomAD chr16:55855361 |
rs2307227
|
- | 0.0326631 | - | |
1203_ASP | GLU |
8.3kJPN chr16:55855361 |
rs2307227
|
- | 0.0101 | - | |
1212_PRO | SER |
8.3kJPN chr16:55855336 |
-
|
- | 0.0001 | - | |
1220_GLU | GLY |
gnomAD chr16:55855311 |
rs200707504
|
- | 0.000361953 | - | |
1220_GLU | GLY |
8.3kJPN chr16:55855311 |
rs200707504
|
- | 0.0091 | - | |
1242_ARG | TRP |
8.3kJPN chr16:55854358 |
rs376173751
|
- | 0.0004 | - | |
1249_VAL | MET |
8.3kJPN chr16:55854337 |
rs778524104
|
- | 0.0001 | - | |
1264_LEU | PHE |
8.3kJPN chr16:55854290 |
-
|
- | 0.0001 | - | |
1269_ALA | SER |
gnomAD chr16:55853545 |
rs115629050
|
- | 0.0326835 | - | |
1269_ALA | SER |
8.3kJPN chr16:55853545 |
rs115629050
|
- | 0.0104 | - | |
1272_ALA | SER |
8.3kJPN chr16:55853536 |
rs1567499789
|
- | 0.0001 | - | |
1277_THR | ALA |
8.3kJPN chr16:55853521 |
rs200489319
|
- | 0.0002 | - | |
1284_HIS | GLN |
gnomAD chr16:55853498 |
rs114119971
|
- | 0.00449884 | - | |
1287_ARG | LEU |
gnomAD chr16:55853490 |
rs560426140
|
- | 0.000131271 | - | |
1287_ARG | TER |
8.3kJPN chr16:55853491 |
rs144078935
|
- | 0.0004 | - | |
1290_THR | MET |
8.3kJPN chr16:55853481 |
rs202001817
|
- | 0.0007 | - | |
1297_THR | MET |
8.3kJPN chr16:55853460 |
rs767343447
|
- | 0.0001 | - | |
1302_LYS | GLU |
8.3kJPN chr16:55850874 |
rs537106281
|
- | 0.0033 | - | |
1309_GLN | PRO |
8.3kJPN chr16:55850852 |
-
|
- | 0.0001 | - | |
1339_ARG | GLY |
8.3kJPN chr16:55846883 |
-
|
- | 0.0001 | - | |
1340_ASN | LYS |
gnomAD chr16:55846878 |
rs576295379
|
- | 0.00075164 | - | |
1347_MET | VAL |
gnomAD chr16:55846859 |
rs145135221
|
- | 0.000258472 | - | |
1349_GLY | ARG |
8.3kJPN chr16:55846853 |
rs757978769
|
- | 0.0001 | - | |
1366_TYR | CYS |
gnomAD chr16:55844909 |
rs146595460
|
- | 0.000804232 | - | |
1377_THR | SER |
gnomAD chr16:55844877 |
rs762507008
|
- | 0.00011143 | - | |
1379_MET | VAL |
gnomAD chr16:55844871 |
rs140704082
|
- | 0.00103065 | - | |
1399_ALA | THR |
8.3kJPN chr16:55844549 |
-
|
- | 0.0001 | - | |
1404_LEU | PHE |
8.3kJPN chr16:55844532 |
-
|
- | 0.0001 | - | |
1405_GLY | GLU |
8.3kJPN chr16:55844530 |
-
|
- | 0.0001 | - | |
1421_ILE | ARG |
8.3kJPN chr16:55844482 |
rs748876242
|
- | 0.0001 | - | |
1432_ILE | THR |
gnomAD chr16:55844449 |
rs114277361
|
- | 0.000111361 | - | |
1433_VAL | ALA |
8.3kJPN chr16:55844446 |
-
|
- | 0.0001 | - | |
1435_ARG | GLY |
8.3kJPN chr16:55844441 |
rs376976316
|
- | 0.0004 | - | |
1438_ARG | LYS |
8.3kJPN chr16:55844431 |
-
|
- | 0.0005 | - |