PDB ID 2HUE     CHAIN C
Protein name Histone H4
Uniprot Accession P62799
The number of similar proteins 293
The number of binding states 29
The number of binding partners 26

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MKVLRDNIQG   ITKPAIRRLA   RRGGVKRISG   LIYEETRGVL   KVFLENVIRD   50
51   AVTYTEHAKR   KTVTAMDVVY   ALKRQGRTLY   GFGG     100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
20_LYS GLN 8.3kJPN
chr6:26247145 		rs1354706295
- 0.0001 -
23_ARG TER 8.3kJPN
chr6:26204942 		rs372764747
- 0.0002 -
23_ARG CYS 8.3kJPN
chr6:27841219 		-
- 0.0001 -
26_ILE SER gnomAD
chr6:26189225 		rs750884941
- 0.000111404 -
31_LYS THR ClinVar
chr6:26204967 		-
Pathogenic - Tessadori-Van Haaften neurodevelopmental syndrome 3 [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950]
31_LYS GLN 8.3kJPN
chr6:26027387 		-
- 0.0001 -
32_PRO LEU ClinVar
chr6:26204970 		-
Likely pathogenic - not provided|Inborn genetic diseases [MedGen:C3661900|MeSH:D030342,MedGen:C0950123]
32_PRO LEU ClinVar
chr6:26104273 		-
Pathogenic - not provided [MedGen:CN517202]
32_PRO ARG ClinVar
chr6:26104273 		-
Likely pathogenic - not provided [MedGen:CN517202]
32_PRO ARG ClinVar
chr6:26204970 		-
Pathogenic - Tessadori-Van Haaften neurodevelopmental syndrome 3 [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950]
33_ALA VAL 8.3kJPN
chr6:26022007 		rs776166186
- 0.0001 -
33_ALA THR 8.3kJPN
chr6:26027381 		-
- 0.0001 -
34_ILE LEU 8.3kJPN
chr6:26189202 		rs1011647555
- 0.0001 -
34_ILE THR 8.3kJPN
chr6:26204976 		rs768482468
- 0.0001 -
35_ARG TRP ClinVar
chr6:26204978 		-
Pathogenic - Tessadori-Van Haaften neurodevelopmental syndrome 3 [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950]
35_ARG TRP ClinVar
chr6:27792008 		-
Likely pathogenic - Tessadori-van Haaften neurodevelopmental syndrome 2 [MONDO:MONDO:0030730,MedGen:C5676923,OMIM:619759]
36_ARG PRO ClinVar
chr6:26204982 		-
Likely pathogenic - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
37_LEU PHE 8.3kJPN
chr6:27107199 		-
- 0.0001 -
40_ARG LEU ClinVar
chr6:27107209 		-
Pathogenic - Tessadori-Van Haaften neurodevelopmental syndrome 4 [MONDO:MONDO:0031000,MedGen:C5677016,OMIM:619951]
45_ARG SER ClinVar
chr6:26104311 		-
Likely pathogenic - Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
45_ARG TER 8.3kJPN
chr6:26027345 		rs767025164
- 0.0001 -
47_SER TER 8.3kJPN
chr6:26240796 		-
- 0.0001 -
50_ILE VAL gnomAD
chr6:26247055 		rs370289402
- 0.000115357 -
50_ILE LEU 8.3kJPN
chr6:26205023 		rs756223901
- 0.0001 -
50_ILE VAL 8.3kJPN
chr6:26240804 		rs1367180593
- 0.0001 -
51_TYR PHE 8.3kJPN
chr6:27799151 		-
- 0.0001 -
52_GLU ALA 8.3kJPN
chr6:26027323 		-
- 0.0001 -
52_GLU GLY 8.3kJPN
chr6:26240811 		rs773141004
- 0.0001 -
54_THR ILE gnomAD
chr6:26247042 		rs573072581
- 0.000167058 -
54_THR SER 8.3kJPN
chr6:26240817 		rs1046492095
- 0.0001 -
55_ARG HIS 8.3kJPN
chr6:26027314 		rs1195708639
- 0.0002 -
55_ARG GLN 8.3kJPN
chr12:14923852 		rs534031465
- 0.0001 -
55_ARG TRP 8.3kJPN
chr12:14923853 		rs762150713
- 0.0001 -
57_VAL GLY 8.3kJPN
chr6:26027308 		rs1031808362
- 0.0001 -
57_VAL LEU 8.3kJPN
chr6:26189133 		-
- 0.0001 -
57_VAL ILE 8.3kJPN
chr6:26205044 		-
- 0.0001 -
57_VAL LEU 8.3kJPN
chr6:26247034 		rs200377159
- 0.0082 -
57_VAL MET 8.3kJPN
chr6:27107259 		rs1013949364
- 0.0001 -
60_VAL ALA 8.3kJPN
chr6:26027299 		rs780045847
- 0.0001 -
61_PHE LEU 8.3kJPN
chr6:27799120 		rs746877857
- 0.0002 -
64_ASN ASP 8.3kJPN
chr6:26240846 		-
- 0.0001 -
65_VAL ILE 8.3kJPN
chr6:26104371 		-
- 0.0001 -
66_ILE VAL gnomAD
chr6:26027282 		rs777598662
- 0.000131219 -
67_ARG TRP 8.3kJPN
chr6:27107289 		rs1291040170
- 0.0005 -
67_ARG HIS 8.3kJPN
chr12:14923816 		-
- 0.0001 -
68_ASP GLY 8.3kJPN
chr6:26027275 		-
- 0.0001 -
70_VAL MET 8.3kJPN
chr6:26246995 		rs140916075
- 0.0001 -
73_THR PRO 8.3kJPN
chr12:14923799 		rs1171400276
- 0.0002 -
74_GLU ASP 8.3kJPN
chr6:27107312 		-
- 0.0001 -
75_HIS ARG ClinVar
chr6:27107314 		-
Pathogenic - Tessadori-Van Haaften neurodevelopmental syndrome 4 [MONDO:MONDO:0031000,MedGen:C5677016,OMIM:619951]
77_LYS GLN ClinVar
chr6:26205104 		-
Likely pathogenic - H4C5-related condition [-]
77_LYS ASN 8.3kJPN
chr6:26240887 		-
- 0.0001 -
78_ARG PRO gnomAD
chr6:26022142 		rs143300286
- 0.000374421 -
78_ARG CYS gnomAD
chr6:26027246 		rs777473620
- 0.000151114 -
78_ARG PRO gnomAD
chr6:26240889 		rs747684677
- 0.000132062 -
80_THR ALA 8.3kJPN
chr12:14923778 		rs760388462
- 0.0001 -
81_VAL ALA gnomAD
chr6:26022151 		rs199857326
- 0.000227104 -
82_THR ILE gnomAD
chr6:26022154 		rs776076104
- 0.000299053 -
82_THR ILE 8.3kJPN
chr6:26027233 		rs150504596
- 0.0001 -
82_THR ILE 8.3kJPN
chr6:26189057 		rs144742137
- 0.005 -
82_THR SER 8.3kJPN
chr6:26246958 		-
- 0.0001 -
82_THR ILE 8.3kJPN
chr6:27799058 		rs372460457
- 0.0001 -
83_ALA VAL gnomAD
chr6:26022157 		rs147105535
- 0.00173549 -
83_ALA SER 8.3kJPN
chr6:26240903 		-
- 0.0001 -
84_MET ILE 8.3kJPN
chr6:26027226 		-
- 0.0001 -
84_MET ILE 8.3kJPN
chr6:27792157 		-
- - -
85_ASP GLY gnomAD
chr6:27841032 		rs201833445
- 0.000127245 -
85_ASP GLU 8.3kJPN
chr6:26022164 		-
- 0.0001 -
85_ASP ASN 8.3kJPN
chr6:26240909 		-
- 0.0004 -
86_VAL LEU 8.3kJPN
chr6:26027222 		-
- 0.0001 -
87_VAL ILE 8.3kJPN
chr6:26104437 		-
- 0.0001 -
88_TYR HIS 8.3kJPN
chr12:14923754 		-
- 0.0001 -
89_ALA SER gnomAD
chr6:26104443 		rs144469714
- 0.000318441 -
89_ALA THR 8.3kJPN
chr6:26104443 		rs144469714
- 0.0001 -
89_ALA VAL 8.3kJPN
chr6:26104444 		-
- 0.0001 -
89_ALA THR 8.3kJPN
chr12:14923751 		rs776707867
- 0.0001 -
90_LEU PRO 8.3kJPN
chr6:26205144 		-
- 0.0001 -
91_LYS GLN ClinVar
chr6:26104449 		rs1763200003
Pathogenic - HIST1H4C-associated disorder [-]
91_LYS GLU ClinVar
chr6:27792176 		rs2113887393
Pathogenic - Tessadori-van Haaften neurodevelopmental syndrome 2 [MONDO:MONDO:0030730,MedGen:C5676923,OMIM:619759]
91_LYS GLN ClinVar
chr6:27792176 		rs2113887393
Pathogenic - Tessadori-van Haaften neurodevelopmental syndrome 1 [MONDO:MONDO:0030729,MedGen:C5676922,OMIM:619758]
91_LYS ARG ClinVar
chr6:26104450 		rs2113784630
Likely pathogenic - Tessadori-van Haaften neurodevelopmental syndrome 1 [MONDO:MONDO:0030729,MedGen:C5676922,OMIM:619758]
91_LYS GLU ClinVar
chr6:26104449 		rs1763200003
Pathogenic - Tessadori-van Haaften neurodevelopmental syndrome 1 [MONDO:MONDO:0030729,MedGen:C5676922,OMIM:619758]
92_ARG CYS 8.3kJPN
chr6:26104452 		-
- 0.0001 -
95_ARG GLY 8.3kJPN
chr6:27792188 		-
- 0.0001 -
98_TYR HIS ClinVar
chr6:26205167 		-
Likely pathogenic - Tessadori-Van Haaften neurodevelopmental syndrome 3|Inborn genetic diseases [MONDO:MONDO:0030993,MedGen:C5774310,OMIM:619950|MeSH:D030342,MedGen:C0950123]
99_GLY VAL 8.3kJPN
chr6:26027182 		-
- 0.0001 -
99_GLY ASP 8.3kJPN
chr6:27840990 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.