PDB ID 2IAE CHAIN B
Protein name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Uniprot Accession Q13362
The number of similar proteins 10
The number of binding states 4
The number of binding partners 4
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
2IAE (CHAIN: B)
1 P67775   Q96DH3  
2 Monomeric state
3 O60566  
4 Q5FBB7   P67775  

Q76MZ3  
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partners
  1
  0
Sequence information
1   IRDVPPADQE   KLFIQKLRQC   CVLFDFVSDP   LSDLKWKEVK   RAALSEMVEY   50
51   ITHNRNVITE   PIYPEVVHMF   AVNMFRTLPP   SSNPTGAEFD   PEEDEPTLEA   100
101   AWPHLQLVYE   FFLRFLESPD   FQPNIAKKYI   DQKFVLQLLE   LFDSEDPRER   150
151   DFLKTTLHRI   YGKFLGLRAY   IRKQINNIFY   RFIYETEHHN   GIAELLEILG   200
201   SIINGFALPL   KEEHKIFLLK   VLLPLHKVKS   LSVYHPQLAY   CVVQFLEKDS   250
251   TLTEPVVMAL   LKYWPKTHSP   KEVMFLNELE   EILDVIEPSE   FVKIMEPLFR   300
301   QLAKCVSSPH   FQVAERALYY   WNNEYIMSLI   SDNAAKILPI   MFPSLYRNSK   350
351   THWNKTIHGL   IYNALKLFME   MNQKLFDDCT   QQFKAEKLKE   KLKMKEREEA   400
401   WVKIENL           450
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
121_GLU LYS ClinVar
chr6:42975000
rs863225081 Pathogenic not provided [MedGen:CN517202]
122_GLU LYS ClinVar
chr6:42975003
rs863225082 Pathogenic/Likely pathogenic Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
124_GLU LYS ClinVar
chr6:42975009
rs863225079 Pathogenic Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
125_PRO ARG ClinVar
chr6:42975013
rs876657383 Pathogenic Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]; not provided [MedGen:CN517202]
131_TRP ARG ClinVar
chr6:42975030
rs869320691 Pathogenic Mental retardation, autosomal dominant 35 [MedGen:C4225354,OMIM:616355,Orphanet:ORPHA457279]
131_TRP ARG ClinVar
chr6:42975030
rs869320691 Pathogenic not provided [MedGen:CN517202]
175_ASP VAL ClinVar
chr6:42975698
rs1064794719 Likely pathogenic not provided [MedGen:CN517202]
344_GLU LYS ClinVar
chr6:42977066
rs863225080 Pathogenic/Likely pathogenic Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; not provided [MedGen:CN517202]