PDB ID 2IIP     CHAIN A
Protein name Nicotinamide N-methyltransferase
Uniprot Accession P40261
The number of similar proteins 26
The number of binding states 3
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2IIP (CHAIN: A)
1 Monomeric state
2 P40261  
3 P40261   P40261  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MGSSHHHHHH   SSGLVPRGSM   ESGFTSKDTY   LSHFNPRDYL   EKYYKFGSRH   50
51   SAESQILKHL   LKNLFKIFCL   DGVKGDLLID   IGSGPTIYQL   LSACESFKEI   100
101   VVTDYSDQNL   QELEKWLKAA   PAAFDWSPVV   TYVCDLEGNR   VKGPEKEEKL   150
151   RQAVKQVLKC   DVTQSQPLGA   VPLPPADCVL   STLCLDAACP   DLPTYCRALR   200
201   NLGSLLKPGG   FLVIMDALKS   SYYMIGEQKF   SSLPLGREAV   EAAVKEAGYT   250
251   IEWFEVISQS   YSSTMANNEG   LFSLVARKLS   RPL     300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
4_GLY ALA 8.3kJPN
chr11:114167289 		-
- 0.0001 -
56_GLY ARG 8.3kJPN
chr11:114168684 		rs749659903
- 0.0001 -
64_SER PHE gnomAD
chr11:114168709 		rs766274630
- 0.000179072 -
64_SER PHE 8.3kJPN
chr11:114168709 		rs766274630
- 0.0001 -
67_THR ALA 8.3kJPN
chr11:114168717 		rs200017623
- 0.0007 -
73_SER CYS gnomAD
chr11:114168736 		rs750737109
- 0.000103441 -
83_VAL GLY 8.3kJPN
chr11:114168766 		rs1282783636
- 0.0004 -
101_GLU LYS 8.3kJPN
chr11:114168819 		-
- 0.0004 -
105_PHE LEU 8.3kJPN
chr11:114168833 		rs1160747772
- 0.0002 -
114_VAL MET 8.3kJPN
chr11:114168858 		-
- 0.0002 -
145_GLN ARG gnomAD
chr11:114182838 		rs201257954
- 0.000191527 -
160_VAL LEU gnomAD
chr11:114182882 		rs199618034
- 0.000115462 -
164_LEU PRO 8.3kJPN
chr11:114182895 		rs1482391482
- 0.0001 -
169_ALA THR 8.3kJPN
chr11:114182909 		rs374377399
- 0.0008 -
179_ALA VAL gnomAD
chr11:114182940 		rs375878881
- 0.000214946 -
182_ASN LYS gnomAD
chr11:114182950 		rs200319273
- 0.000119384 -
204_TYR ASP 8.3kJPN
chr11:114183014 		-
- 0.0001 -
215_PRO LEU 8.3kJPN
chr11:114183048 		-
- 0.0001 -
222_GLU LYS 8.3kJPN
chr11:114183068 		rs201804258
- 0.0015 -
239_SER LEU gnomAD
chr11:114183120 		rs141240468
- 0.000572619 -
257_ALA VAL 8.3kJPN
chr11:114183174 		rs576476423
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

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