PDB ID 2IO5     CHAIN B
Protein name Histone H3.1
Uniprot Accession P84233
The number of similar proteins 386
The number of binding states 19
The number of binding partners 15

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   ARTKQTARKS   TGGKAPRKQL   ATKAARKSAP   ATGGVKKPHR   YRPGTVALRE   50
51   IRRYQKSTEL   LIRKLPFQRL   VREIAQDFKT   DLRFQSSAVM   ALQEASEAYL   100
101   VGLFEDTNLC   AIHAKRVTIM   PKDIQLARRI   RGERA     150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
61_LEU PHE 8.3kJPN
chr6:26020901 		rs1026102996
- 0.0001 -
62_ILE VAL 8.3kJPN
chr6:26271426 		rs889798197
- 0.0001 -
63_ARG CYS gnomAD
chr1:228612837 		rs201294185
- 0.000433438 -
63_ARG GLY gnomAD
chr1:228612837 		rs201294185
- 0.000139177 -
63_ARG CYS 8.3kJPN
chr1:228612837 		rs201294185
- 0.0035 -
66_PRO LEU gnomAD
chr6:26020917 		rs143364138
- 0.000433562 -
66_PRO HIS gnomAD
chr12:31944904 		rs150875482
- 0.000186886 -
66_PRO SER 8.3kJPN
chr1:228612828 		rs201625757
- 0.0001 -
66_PRO SER 8.3kJPN
chr6:26020916 		rs369516106
- 0.0001 -
66_PRO LEU 8.3kJPN
chr6:26020917 		rs143364138
- 0.0112 -
66_PRO LEU 8.3kJPN
chr6:26250634 		rs768039332
- 0.0005 -
66_PRO LEU 8.3kJPN
chr6:26271413 		rs756545644
- 0.0001 -
66_PRO LEU 8.3kJPN
chr6:27778051 		rs769595845
- 0.0001 -
67_PHE LEU gnomAD
chr1:228612823 		rs144064739
- 0.000123271 -
67_PHE TYR gnomAD
chr1:228612824 		rs148655394
- 0.000123269 -
67_PHE SER gnomAD
chr6:26020920 		rs147504514
- 0.000119325 -
67_PHE LEU 8.3kJPN
chr1:228612823 		rs144064739
- 0.0095 -
67_PHE TYR 8.3kJPN
chr1:228612824 		rs148655394
- 0.0095 -
67_PHE LEU 8.3kJPN
chr6:26045842 		-
- 0.0001 -
68_GLN TER 8.3kJPN
chr6:26020922 		rs181930473
- 0.0018 -
69_ARG TRP 8.3kJPN
chr1:149785029 		-
- 0.0001 -
71_VAL LEU 8.3kJPN
chr6:26250620 		-
- 0.0001 -
72_ARG TER 8.3kJPN
chr6:26225599 		rs556601521
- 0.0001 -
72_ARG HIS 8.3kJPN
chr6:26250616 		-
- 0.0001 -
72_ARG GLN 8.3kJPN
chr6:26271395 		-
- 0.0001 -
74_ILE THR 8.3kJPN
chr12:31944880 		rs765335300
- 0.0007 -
75_ALA THR 8.3kJPN
chr1:149785011 		-
- 0.0001 -
75_ALA THR 8.3kJPN
chr6:26225608 		-
- 0.0001 -
76_GLN TER 8.3kJPN
chr1:228612798 		-
- 0.0001 -
79_LYS TER 8.3kJPN
chr6:26271375 		rs1390395268
- 0.0013 -
81_ASP GLU 8.3kJPN
chr6:26020963 		-
- 0.0001 -
82_LEU TRP 8.3kJPN
chr6:27778099 		-
- 0.0001 -
83_ARG GLY ClinVar
chr1:226253478 		rs1657904113
Likely pathogenic - Neurodevelopmental disorder|Bryant-Li-Bhoj neurodevelopmental syndrome 1 [MONDO:MONDO:0700092,MeSH:D065886,MedGen:C1535926|MONDO:MONDO:0030606,MedGen:C5676905,OMIM:619720]
83_ARG PRO 8.3kJPN
chr1:149784986 		-
- 0.0004 -
85_GLN HIS 8.3kJPN
chr6:26250576 		-
- 0.0001 -
85_GLN ARG 8.3kJPN
chr12:31944847 		-
- 0.0001 -
86_SER GLY gnomAD
chr6:26020976 		rs145571906
- 0.000326124 -
86_SER ARG 8.3kJPN
chr6:27778112 		-
- 0.0001 -
87_SER PRO gnomAD
chr1:149784975 		rs782720234
- 0.000105161 -
88_ALA SER 8.3kJPN
chr1:228612762 		-
- 0.0001 -
90_MET LYS 8.3kJPN
chr6:26197207 		-
- 0.0004 -
90_MET THR 8.3kJPN
chr6:26271341 		rs759342007
- 0.0001 -
91_ALA THR 8.3kJPN
chr12:31944830 		rs928601270
- 0.0001 -
92_LEU VAL 8.3kJPN
chr1:149784960 		-
- 0.0001 -
95_ALA VAL 8.3kJPN
chr6:26045925 		rs752518862
- 0.0001 -
95_ALA ASP 8.3kJPN
chr6:26225669 		-
- 0.0001 -
96_CYS TRP 8.3kJPN
chr6:26031998 		-
- 0.0001 -
97_GLU LYS 8.3kJPN
chr1:228612735 		rs201439742
- - -
98_ALA VAL 8.3kJPN
chr6:26021013 		rs748134309
- 0.0001 -
99_TYR HIS 8.3kJPN
chr6:26250536 		rs1331582268
- 0.0001 -
100_LEU PHE 8.3kJPN
chr6:26031986 		-
- 0.0002 -
103_LEU PRO 8.3kJPN
chr6:26045949 		-
- 0.0001 -
104_PHE LEU gnomAD
chr1:149784922 		rs201064709
- 0.00128519 -
104_PHE SER 8.3kJPN
chr6:26225696 		-
- 0.0001 -
105_GLU GLY 8.3kJPN
chr1:228612710 		rs868727723
- 0.0001 -
106_ASP VAL gnomAD
chr6:27778171 		rs139893026
- 0.000369864 -
108_ASN SER 8.3kJPN
chr6:26045964 		-
- 0.0001 -
111_ALA VAL gnomAD
chr12:31944769 		rs113082334
- 0.00254881 -
114_ALA GLY 8.3kJPN
chr1:226259113 		rs749423281
- 0.0088 -
114_ALA SER 8.3kJPN
chr6:26250491 		-
- 0.0001 -
117_VAL ALA gnomAD
chr12:31944751 		rs540141669
- 0.00016303 -
117_VAL LEU 8.3kJPN
chr1:149784885 		-
- 0.0001 -
119_ILE VAL 8.3kJPN
chr6:26031931 		rs1362284538
- 0.0001 -
119_ILE PHE 8.3kJPN
chr6:27778209 		-
- 0.0001 -
119_ILE VAL 8.3kJPN
chr6:27858213 		-
- 0.0001 -
120_MET ILE ClinVar
chr1:226259132 		rs2102742562
Pathogenic - Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]; Delayed speech and language development [Human Phenotype Ontology:HP:0000750,Human Phenotype Ontology:HP:0002116,Human Phenotype Ontology:HP:0002117,Human Phenotype Ontology:HP:0002336,Human Phenotype Ontology:HP:0002399,Human Phenotype Ontology:HP:0002498,Human Phenotype Ontology:HP:0006936,Human Phenotype Ontology:HP:0007004,Human Phenotype Ontology:HP:0007127,Human Phenotype Ontology:HP:0007170,Human Phenotype Ontology:HP:0007172,MedGen:C0454644]; Short stature [Human Phenotype Ontology:HP:0001509,Human Phenotype Ontology:HP:0003501,Human Phenotype Ontology:HP:0003507,Human Phenotype Ontology:HP:0003512,Human Phenotype Ontology:HP:0003518,Human Phenotype Ontology:HP:0003519,Human Phenotype Ontology:HP:0004322,Human Phenotype Ontology:HP:0008871,Human Phenotype Ontology:HP:0008882,Human Phenotype Ontology:HP:0008888,Human Phenotype Ontology:HP:0008913,MedGen:C0349588]; Brain imaging abnormality [Human Phenotype Ontology:HP:0410263,MedGen:C2711610]; Global developmental delay|Bryant-Li-Bhoj neurodevelopmental syndrome 1 [Human Phenotype Ontology:HP:0000754,Human Phenotype Ontology:HP:0001255,Human Phenotype Ontology:HP:0001263,Human Phenotype Ontology:HP:0001277,Human Phenotype Ontology:HP:0001292,Human Phenotype Ontology:HP:0002433,Human Phenotype Ontology:HP:0002473,Human Phenotype Ontology:HP:0002532,Human Phenotype Ontology:HP:0006793,Human Phenotype Ontology:HP:0006867,Human Phenotype Ontology:HP:0006885,Human Phenotype Ontology:HP:0006935,Human Phenotype Ontology:HP:0007005,Human Phenotype Ontology:HP:0007094,Human Phenotype Ontology:HP:0007106,Human Phenotype Ontology:HP:0007174,Human Phenotype Ontology:HP:0007224,Human Phenotype Ontology:HP:0007228,Human Phenotype Ontology:HP:0007342,Human Phenotype Ontology:HP:0025356,MedGen:C0557874|MONDO:MONDO:0030606,MedGen:C5676905,OMIM:619720]
120_MET ILE 8.3kJPN
chr6:26250471 		-
- 0.0001 -
121_PRO ARG ClinVar
chr1:226259134 		rs1576203003
Pathogenic/Likely pathogenic - Inborn genetic diseases|H3F3A-related disorders [MeSH:D030342,MedGen:C0950123|]
121_PRO ARG ClinVar
chr17:73774722 		rs2143629995
Pathogenic - Bryant-Li-Bhoj neurodevelopmental syndrome 2 [MONDO:MONDO:0030607,MedGen:C5676906,OMIM:619721]
121_PRO LEU 8.3kJPN
chr6:26031924 		rs990217604
- 0.0001 -
122_LYS ASN gnomAD
chr1:149784868 		rs587674278
- 0.00027116 -
122_LYS GLU gnomAD
chr12:31944737 		rs112159493
- 0.00278745 -
124_ILE PHE 8.3kJPN
chr6:26021090 		rs199573090
- 0.0064 -
124_ILE ASN 8.3kJPN
chr6:26225756 		rs751176237
- - -
124_ILE MET 8.3kJPN
chr12:31944729 		rs758582920
- 0.0001 -
125_GLN ARG ClinVar
chr1:226259146 		rs1276519904
Pathogenic/Likely pathogenic - Inborn genetic diseases|H3F3A-related condition|not provided|Bryant-Li-Bhoj neurodevelopmental syndrome 1 [MeSH:D030342,MedGen:C0950123||MedGen:C3661900|MONDO:MONDO:0030606,MedGen:C5676905,OMIM:619720]
125_GLN ARG ClinVar
chr17:73774710 		rs2143629984
Pathogenic/Likely pathogenic - Bryant-Li-Bhoj neurodevelopmental syndrome 2|H3-3B-related condition [MONDO:MONDO:0030607,MedGen:C5676906,OMIM:619721|]
125_GLN LYS ClinVar
chr17:73774711 		-
Likely pathogenic - Bryant-Li-Bhoj neurodevelopmental syndrome 2 [MONDO:MONDO:0030607,MedGen:C5676906,OMIM:619721]
125_GLN PRO gnomAD
chr6:26021094 		rs199943654
- 0.000191859 -
126_LEU VAL 8.3kJPN
chr6:26021096 		-
- 0.0001 -
126_LEU PHE 8.3kJPN
chr6:27778230 		rs751190554
- 0.0001 -
127_ALA SER 8.3kJPN
chr1:149784855 		-
- 0.0001 -
127_ALA SER 8.3kJPN
chr6:26021099 		-
- 0.0001 -
128_ARG HIS ClinVar
chr1:226259155 		rs1658121882
Pathogenic/Likely pathogenic - Intellectual disability [Human Phenotype Ontology:HP:0000730,Human Phenotype Ontology:HP:0001249,Human Phenotype Ontology:HP:0001267,Human Phenotype Ontology:HP:0001286,Human Phenotype Ontology:HP:0002122,Human Phenotype Ontology:HP:0002192,Human Phenotype Ontology:HP:0002316,Human Phenotype Ontology:HP:0002382,Human Phenotype Ontology:HP:0002386,Human Phenotype Ontology:HP:0002402,Human Phenotype Ontology:HP:0002458,Human Phenotype Ontology:HP:0002482,Human Phenotype Ontology:HP:0002499,Human Phenotype Ontology:HP:0002543,Human Phenotype Ontology:HP:0003767,Human Phenotype Ontology:HP:0006833,Human Phenotype Ontology:HP:0007154,Human Phenotype Ontology:HP:0007176,Human Phenotype Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756]; Delayed speech and language development [Human Phenotype Ontology:HP:0000750,Human Phenotype Ontology:HP:0002116,Human Phenotype Ontology:HP:0002117,Human Phenotype Ontology:HP:0002336,Human Phenotype Ontology:HP:0002399,Human Phenotype Ontology:HP:0002498,Human Phenotype Ontology:HP:0006936,Human Phenotype Ontology:HP:0007004,Human Phenotype Ontology:HP:0007127,Human Phenotype Ontology:HP:0007170,Human Phenotype Ontology:HP:0007172,MedGen:C0454644]; Short stature [Human Phenotype Ontology:HP:0001509,Human Phenotype Ontology:HP:0003501,Human Phenotype Ontology:HP:0003507,Human Phenotype Ontology:HP:0003512,Human Phenotype Ontology:HP:0003518,Human Phenotype Ontology:HP:0003519,Human Phenotype Ontology:HP:0004322,Human Phenotype Ontology:HP:0008871,Human Phenotype Ontology:HP:0008882,Human Phenotype Ontology:HP:0008888,Human Phenotype Ontology:HP:0008913,MedGen:C0349588]; Brain imaging abnormality [Human Phenotype Ontology:HP:0410263,MedGen:C2711610]; Global developmental delay|Bryant-Li-Bhoj neurodevelopmental syndrome 1 [Human Phenotype Ontology:HP:0000754,Human Phenotype Ontology:HP:0001255,Human Phenotype Ontology:HP:0001263,Human Phenotype Ontology:HP:0001277,Human Phenotype Ontology:HP:0001292,Human Phenotype Ontology:HP:0002433,Human Phenotype Ontology:HP:0002473,Human Phenotype Ontology:HP:0002532,Human Phenotype Ontology:HP:0006793,Human Phenotype Ontology:HP:0006867,Human Phenotype Ontology:HP:0006885,Human Phenotype Ontology:HP:0006935,Human Phenotype Ontology:HP:0007005,Human Phenotype Ontology:HP:0007094,Human Phenotype Ontology:HP:0007106,Human Phenotype Ontology:HP:0007174,Human Phenotype Ontology:HP:0007224,Human Phenotype Ontology:HP:0007228,Human Phenotype Ontology:HP:0007342,Human Phenotype Ontology:HP:0025356,MedGen:C0557874|MONDO:MONDO:0030606,MedGen:C5676905,OMIM:619720]
128_ARG PRO 8.3kJPN
chr6:26197093 		-
- 0.0001 -
129_ARG GLN gnomAD
chr12:31944715 		rs147097287
- 0.000214792 -
129_ARG TRP gnomAD
chr12:31944716 		rs563955459
- 0.000175009 -
129_ARG CYS 8.3kJPN
chr6:26225770 		rs966515186
- 0.0001 -
129_ARG PRO 8.3kJPN
chr6:27839705 		-
- 0.0001 -
129_ARG GLN 8.3kJPN
chr12:31944715 		rs147097287
- 0.0002 -
130_ILE ASN 8.3kJPN
chr6:26021109 		rs764923225
- 0.0001 -
132_GLY TRP 8.3kJPN
chr6:27839697 		rs749470205
- 0.0001 -
133_GLU GLN ClinVar
chr6:26021117 		rs764264135
Likely pathogenic - Multiple myeloma [Human Phenotype Ontology:HP:0006775,MONDO:MONDO:0009693,MeSH:D009101,MedGen:C0026764,OMIM:254500,Orphanet:29073,Orphanet:85443]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.