PDB ID 2JK2     CHAIN A
Protein name TRIOSEPHOSPHATE ISOMERASE
PDB 2JK2
The number of similar proteins 51
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2JK2 (CHAIN: A)
1 P60174  
2 Monomeric state

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Only interaction residues
#binding
partners
  1
  0

Sequence information

1   GSAPSRKFFV   GGNWKMNGRK   QSLGELIGTL   NAAKVPADTE   VVCAPPTAYI   50
51   DFARQKLDPK   IAVAAQNCYK   VTNGAFTGEI   SPGMIKDCGA   TWVVLGHSER   100
101   RHVFGESDEL   IGQKVAHALA   EGLGVIACIG   EKLDEREAGI   TEKVVFEQTK   150
151   VIADNVKDWS   KVVLAYEPVW   AIGTGKTATP   QQAQEVHEKL   RGWLKSNVSD   200
201   AVAQSTRIIY   GGSVTGATCK   ELASQPDVDG   FLVGGASLKP   EFVDIINAKQ   250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
26_GLY SER 8.3kJPN
chr12:6976809 		-
- 0.0001 -
33_VAL ALA 8.3kJPN
chr12:6976831 		-
- 0.0001 -
41_CYS TYR ClinVar
chr12:6978037 		rs121964848
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
55_LEU VAL 8.3kJPN
chr12:6978078 		-
- 0.0001 -
62_ALA GLY 8.3kJPN
chr12:6978100 		-
- 0.0001 -
104_GLU ASP ClinVar
chr12:6978338 		rs121964845
Pathogenic/Likely pathogenic - Triosephosphate isomerase deficiency|not provided [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868|MedGen:C3661900]
113_VAL ALA 8.3kJPN
chr12:6978438 		-
- 0.0001 -
118_ALA VAL 8.3kJPN
chr12:6978453 		-
- 0.0004 -
145_GLU TER ClinVar
chr12:6978533 		rs121964850
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
149_VAL PHE gnomAD
chr12:6978545 		rs150585849
- 0.000552882 -
154_VAL MET gnomAD
chr12:6978857 		rs188138723
- 0.0012088 -
163_ALA GLY 8.3kJPN
chr12:6978885 		-
- 0.0001 -
170_ILE VAL ClinVar
chr12:6978905 		rs121964849
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
196_VAL ILE 8.3kJPN
chr12:6979258 		rs782801396
- 0.0001 -
240_PHE LEU ClinVar
chr12:6979518 		rs121964847
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
240_PHE SER ClinVar
chr12:6979519 		rs587777440
Pathogenic - Triosephosphate isomerase deficiency [MONDO:MONDO:0014221,MedGen:C1860808,OMIM:615512,Orphanet:868]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.