PDB ID 2NYM CHAIN A
Protein name Protein phosphatase 2
Uniprot Accession Q96DH3
The number of similar proteins 16
The number of binding states 7
The number of binding partners 6
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
2NYM (CHAIN: A)
1 P67775   Q13362  
2 Monomeric state
3 P67775  
4 Q9W9P1  
5 P67775   Q9Y5P8  
6 P67775   P63151  
7 P67775   Q8BH58  
Downdload
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partners
  5
  4
  3
  2
  1
  0
Sequence information
1   DSLYPIAVLI   DELRNEDVQL   RLNSIKKLST   IALALGVERT   RSELLPFLTD   50
51   TIYDEDEVLL   ALAEQLGTFT   TLVGGPEYVH   CLLPPLESLA   TVEETVVRDK   100
101   AVESLRAISH   EHSPSDLEAH   FVPLVKRLAG   GDWFTSRTSA   CGLFSVCYPR   150
151   VSSAVKAELR   QYFRNLCSDD   TPXVRRAAAS   KLGEFAKVLE   LDNVKSEIIP   200
201   XFSNLASDEQ   DSVRLLAVEA   CVNIAQLLPQ   EDLEALVXPT   LRQAAEDKSW   250
251   RVRYXVADKF   TELQKAVGPE   ITKTDLVPAF   QNLXKDCEAE   VRAAASHKVK   300
301   EFCENLSADC   RENVIXSQIL   PCIKELVSDA   NQHVKSALAS   VIXGLSPILG   350
351   KDNTIEHLLP   LFLAQLKDEC   PEVRLNIISN   LDCVNEVIGI   RQLSQSLLPA   400
401   IVELAEDAKW   RVRLAIIEYX   PLLAGQLGVE   FFDEKLNSLC   XAWLVDHVYA   450
451   IREAATSNLK   KLVEKFGKEW   AHATIIPKVL   AXSGDPNYLH   RXTTLFCINV   500
501   LSEVCGQDIT   TKHXLPTVLR   XAGDPVANVR   FNVAKSLQKI   GPILDNSTLQ   550
551   SEVKPILEKL   TQDQDVDVKY   FAQEALTVLS   LA     600
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
78_GLY ASP ClinVar
chr11:111635566
rs1805076 Pathogenic Lung cancer [MedGen:C0684249,OMIM:211980,SNOMED CT:187875007]
179_PRO LEU ClinVar
chr19:52715971
rs786205228 Pathogenic Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Mental retardation, autosomal dominant 36 [MedGen:C4225352,OMIM:616362,Orphanet:ORPHA457284]; Uterine Carcinosarcoma [MedGen:C0280630]; not provided [MedGen:CN517202]
179_PRO ARG ClinVar
chr19:52715971
rs786205228 Likely pathogenic Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Uterine Carcinosarcoma [MedGen:C0280630]
182_ARG TRP ClinVar
chr19:52715979
rs786205227 Pathogenic Mental retardation, autosomal dominant 36 [MedGen:C4225352,OMIM:616362,Orphanet:ORPHA457284]; not provided [MedGen:CN517202]
183_ARG TRP ClinVar
chr19:52715982
rs1057519946 Likely pathogenic Adenocarcinoma of prostate [MedGen:C0007112]; Adenocarcinoma of stomach [MedGen:C0278701]; Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]; Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Neoplasm of the breast [Human Phenotype Ontology:HP:0100013,MeSH:D001943,MedGen:C1458155,Orphanet:ORPHA180250,SNOMED CT:126926005]; Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]; Ovarian Serous Cystadenocarcinoma [MedGen:C0279663]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]; Uterine Carcinosarcoma [MedGen:C0280630]
183_ARG GLN ClinVar
chr19:52715983
rs1057519947 Likely pathogenic Adenocarcinoma of prostate [MedGen:C0007112]; Adenocarcinoma of stomach [MedGen:C0278701]; Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]; Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Neoplasm of the breast [Human Phenotype Ontology:HP:0100013,MeSH:D001943,MedGen:C1458155,Orphanet:ORPHA180250,SNOMED CT:126926005]; Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]; Ovarian Serous Cystadenocarcinoma [MedGen:C0279663]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]; Uterine Carcinosarcoma [MedGen:C0280630]; not provided [MedGen:CN517202]
183_ARG GLY ClinVar
chr19:52715982
rs1057519946 Likely pathogenic Adenocarcinoma of prostate [MedGen:C0007112]; Adenocarcinoma of stomach [MedGen:C0278701]; Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]; Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Neoplasm of the breast [Human Phenotype Ontology:HP:0100013,MeSH:D001943,MedGen:C1458155,Orphanet:ORPHA180250,SNOMED CT:126926005]; Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]; Ovarian Serous Cystadenocarcinoma [MedGen:C0279663]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]; Uterine Carcinosarcoma [MedGen:C0280630]
258_ARG HIS ClinVar
chr19:52716329
rs863225094 Pathogenic Abnormal facial shape [Human Phenotype Ontology:HP:0001999,MedGen:C0424503]; Autistic behavior [Human Phenotype Ontology:HP:0000729,MedGen:C0856975]; Brachydactyly [Human Phenotype Ontology:HP:0001156,MedGen:C0221357,Orphanet:ORPHA294937,SNOMED CT:43476002]; Generalized hypotonia [Human Phenotype Ontology:HP:0001290,MedGen:C1858120]; Impaired use of nonverbal behaviors [Human Phenotype Ontology:HP:0000758,MedGen:C4021798]; Mental retardation, autosomal dominant 36 [MedGen:C4225352,OMIM:616362,Orphanet:ORPHA457284]; Microcephaly [Human Phenotype Ontology:HP:0000252,MedGen:C4551563]; Profound global developmental delay [Human Phenotype Ontology:HP:0012736,MedGen:C3553450]; Stereotypy [Human Phenotype Ontology:HP:0000733,MedGen:C0038273]; Synophrys [Human Phenotype Ontology:HP:0000664,MedGen:C0431447]; not provided [MedGen:CN517202]