PDB ID 2PCX CHAINA
Protein nameCELLULAR TUMOR ANTIGEN P53
Uniprot Accession P04637
The number of similar proteins 65
The number of binding states 7
The number of binding partners 4
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
2PCX (CHAIN: A)
1 Monomeric state
2 Q9DH70
3 Q13625
4 Q12888
5 P04637
6 P04637 P04637
7 P04637 Q12888
Downdload
Format:
Molecule viewer
#binding
partners
  4
  3
  2
  1
  0
Sequence information
1  HHHHHHSSSV   PSQKTYQGSY   GFRLGFLHSG   TAKSVTCTYS   PALNKMFCQL   50
51  AKTCPVQLWV   DSTPPPGTRV   RAMAIYKQSQ   HMTEVVRRCP   HHERCSDSDG   100
101  LAPPQHLIRV   EGNLRVEYLD   DRNTFRHSVV   VPYEPPEVGS   DCTTIHYNYM   150
151  CNSSCMGGMN   RRPILTIITL   EDSSGNLLGR   NSFEVRVCAC   PGRDQRTEEE   200
201  NLRKKSSVVN   SSCMGGMCRR                                      250
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
94_SER LEU VAR_044642 - Unclassified Sporadic cancers
95_SER THR VAR_044644 - Unclassified A sporadic cancer
96_SER PRO VAR_044647 - Unclassified A sporadic cancer
97_VAL ILE VAR_044650 - Unclassified Familial cancer not matching LFS
98_PRO SER VAR_044652 - Unclassified Sporadic cancers
99_SER PRO VAR_044654 - Unclassified A sporadic cancer
100_GLN ARG VAR_044655 - Unclassified A sporadic cancer
101_LYS ARG VAR_044657 - Unclassified Sporadic cancers
102_THR ILE VAR_044658 rs786202717 Unclassified Sporadic cancers
104_GLN LEU VAR_044660 - Unclassified A sporadic cancer
105_GLY VAL VAR_044665 - Unclassified Sporadic cancers
106_SER ARG VAR_044667 - Unclassified A familial cancer not matching LFS
107_TYR HIS VAR_044670 rs368771578 Unclassified A sporadic cancer
108_GLY SER VAR_044672 rs587782461 Unclassified Sporadic cancers
109_PHE SER VAR_044675 - Unclassified Sporadic cancers
110_ARG SER VAR_044678 rs587781371 Unclassified A sporadic cancer
111_LEU ARG VAR_044682 - Unclassified Sporadic cancers
112_GLY SER VAR_044684 - Unclassified Sporadic cancers
113_PHE GLY VAR_045788 - Unclassified A sporadic cancer
115_HIS TYR VAR_044688 - Unclassified Sporadic cancers
116_SER PRO VAR_044691 - Unclassified A sporadic cancer
117_GLY ARG VAR_044693 - Unclassified Sporadic cancers
118_THR ARG VAR_044696 - Unclassified A sporadic cancer
119_ALA THR VAR_044698 - Unclassified A sporadic cancer
120_LYS ARG VAR_044702 - Unclassified Sporadic cancers
121_SER PHE VAR_044703 - Unclassified Sporadic cancers
122_VAL LEU VAR_044704 - Unclassified A sporadic cancer
123_THR ASN VAR_044706 - Unclassified A sporadic cancer
124_CYS TYR VAR_044711 - Unclassified A sporadic cancer
125_THR ARG VAR_044715 - Unclassified Sporadic cancers
126_TYR GLY VAR_045789 - Unclassified A sporadic cancer
127_SER TYR VAR_044723 - Unclassified Sporadic cancers
128_PRO ARG VAR_044726 - Unclassified Sporadic cancers
129_ALA VAL VAR_044729 rs137852792 Unclassified Sporadic cancers
130_LEU VAL VAR_044734 rs863224683 Unclassified Sporadic cancers
131_ASN TYR VAR_044739 rs587782160 Unclassified Sporadic cancers
132_LYS TRP VAR_045791 - Unclassified A sporadic cancer
133_MET VAL VAR_044748 rs1057280220 Unclassified Sporadic cancers
134_PHE VAL VAR_044752 - Unclassified Sporadic cancers
135_CYS THR VAR_045792 - Unclassified A sporadic cancer
136_GLN ARG VAR_044759 - Unclassified Sporadic cancers
137_LEU VAL VAR_044762 - Unclassified Sporadic cancers
138_ALA THR VAR_044765 - Unclassified Sporadic cancers
139_LYS THR VAR_044769 - Unclassified Sporadic cancers
140_THR SER VAR_044774 - Unclassified Sporadic cancers
141_CYS ALA VAR_045793 - Unclassified A sporadic cancer
142_PRO PHE VAR_045794 - Unclassified Sporadic cancers
143_VAL MET VAR_044787 rs587782620 Unclassified Sporadic cancers
144_GLN ARG VAR_044791 - Unclassified Sporadic cancers
145_LEU VAL VAR_044794 - Unclassified Sporadic cancers
146_TRP SER VAR_044799 - Unclassified Sporadic cancers
147_VAL ILE VAR_044803 - Unclassified Sporadic cancers
148_ASP TYR VAR_044809 - Unclassified Sporadic cancers
149_SER THR VAR_044811 - Unclassified Sporadic cancers
150_THR ARG VAR_044817 - Unclassified A sporadic cancer
151_PRO ARG VAR_044820 - Unclassified Sporadic cancers
152_PRO THR VAR_044824 - Unclassified Sporadic cancers
153_PRO PHE VAR_045795 - Unclassified A sporadic cancer
154_GLY ILE VAR_045796 - Unclassified Sporadic cancers
155_THR SER VAR_044838 rs786202752 Unclassified Sporadic cancers
156_ARG SER VAR_044843 - Unclassified Sporadic cancers
157_VAL LEU VAR_044846 - Unclassified Sporadic cancers
158_ARG TYR VAR_045798 - Unclassified A sporadic cancer
159_ALA PHE VAR_045799 rs730882022 Unclassified A sporadic cancer
160_MET VAL VAR_044859 - Unclassified Sporadic cancers
161_ALA PHE VAR_045800 - Unclassified A sporadic cancer
162_ILE THR VAR_044868 - Unclassified Sporadic cancers
163_TYR SER VAR_044872 - Unclassified Sporadic cancers
164_LYS THR VAR_044876 - Unclassified Sporadic cancers
165_GLN PRO VAR_044879 - Unclassified Sporadic cancers
166_SER THR VAR_044883 - Unclassified Sporadic cancers
167_GLN ARG VAR_044887 - Unclassified Sporadic cancers
168_HIS VAL VAR_045801 - Unclassified A sporadic cancer
169_MET VAL VAR_044895 - Unclassified Sporadic cancers
170_THR PRO VAR_044898 - Unclassified A sporadic cancer
171_GLU VAL VAR_044904 - Unclassified Sporadic cancers
172_VAL ILE VAR_044908 - Unclassified Sporadic cancers
173_VAL TRP VAR_045802 - Unclassified A sporadic cancer
174_ARG TRP VAR_044915 - Unclassified Sporadic cancers
175_ARG SER VAR_044917 - Unclassified Sporadic cancers
176_CYS TYR VAR_044921 rs786202962 Unclassified Sporadic cancers
177_PRO ILE VAR_045804 - Unclassified A sporadic cancer
178_HIS TYR VAR_044932 - Unclassified Sporadic cancers
179_HIS TYR VAR_044939 rs587780070 Disease Li-Fraumeni syndrome (LFS) [MIM:151623]
180_GLU VAL VAR_044945 - Unclassified A sporadic cancer
181_ARG SER VAR_044950 rs587782596 Unclassified Sporadic cancers
182_CYS TYR VAR_044952 - Unclassified Sporadic cancers
183_SER PRO VAR_044954 - Unclassified Sporadic cancers
184_ASP ASN VAR_047169 rs72661117 Unclassified Sporadic cancers
185_SER THR VAR_044963 - Unclassified A sporadic cancer
186_ASP VAL VAR_044968 - Unclassified Sporadic cancers
187_GLY ASN VAR_045805 - Unclassified A sporadic cancer
188_LEU VAL VAR_044973 - Unclassified Sporadic cancers
189_ALA VAL VAR_044978 rs121912665 Unclassified A familial cancer not matching LFS
190_PRO THR VAR_044983 rs876660254 Unclassified Sporadic cancers
191_PRO SER VAR_044987 rs868590738 Unclassified Sporadic cancers
192_GLN PRO VAR_044991 - Unclassified Sporadic cancers
193_HIS TYR VAR_044996 rs876658468 Unclassified Sporadic cancers
194_LEU VAL VAR_045000 - Unclassified Sporadic cancers
195_ILE LEU VAR_047172 - Unclassified A sporadic cancer
196_ARG SER VAR_045009 - Unclassified A sporadic cancer
197_VAL MET VAR_045013 rs786204041 Disease Li-Fraumeni syndrome (LFS) [MIM:151623]
198_GLU VAL VAR_045017 - Unclassified A sporadic cancer
199_GLY VAL VAR_045021 - Unclassified Sporadic cancers
200_ASN PRO VAR_045807 - Unclassified A sporadic cancer
201_LEU SER VAR_045029 - Unclassified A sporadic cancer
202_ARG SER VAR_045035 - Unclassified Sporadic cancers
203_VAL TRP VAR_045808 - Unclassified A sporadic cancer
204_GLU VAL VAR_045045 - Unclassified A sporadic cancer
205_TYR PHE VAR_047175 - Unclassified Sporadic cancers
206_LEU MET VAR_045050 - Unclassified A sporadic cancer
207_ASP TYR VAR_045056 - Unclassified A sporadic cancer
208_ASP ILE VAR_045809 - Unclassified A sporadic cancer
209_ARG THR VAR_045066 - Unclassified Sporadic cancers
210_ASN TYR VAR_045073 - Unclassified A familial cancer not matching LFS
211_THR SER VAR_045078 - Unclassified Sporadic cancers
212_PHE TYR VAR_045083 - Unclassified Sporadic cancers
213_ARG TRP VAR_045086 - Unclassified Sporadic cancers
214_HIS GLN VAR_047177 rs587781386 Unclassified Sporadic cancers
215_SER LYS VAR_045810 - Unclassified Sporadic cancers
216_VAL TRP VAR_045811 - Unclassified A sporadic cancer
217_VAL MET VAR_047178 rs35163653 Polymorphism -
218_VAL MET VAR_045110 rs878854072 Unclassified Sporadic cancers
219_PRO CYS VAR_045812 - Unclassified A sporadic cancer
220_TYR ASN VAR_045118 - Unclassified Sporadic cancers
221_GLU GLN VAR_045123 - Unclassified Sporadic cancers
222_PRO THR VAR_045129 - Unclassified Sporadic cancers
223_PRO ALA VAR_047179 - Unclassified A sporadic cancer
224_GLU VAL VAR_045138 - Unclassified A sporadic cancer
225_VAL LEU VAR_045144 rs746504075 Unclassified A sporadic cancer
226_GLY ASP VAR_047180 - Unclassified Sporadic cancers
227_SER THR VAR_045151 - Disease Li-Fraumeni syndrome (LFS) [MIM:151623]
228_ASP PRO VAR_045845 - Unclassified A sporadic cancer
229_CYS ASN VAR_045846 - Unclassified A sporadic cancer
230_THR SER VAR_045165 - Unclassified Sporadic cancers
231_THR SER VAR_045169 - Unclassified Sporadic cancers
232_ILE VAL VAR_045174 - Unclassified Sporadic cancers
233_HIS ARG VAR_047181 rs879254233 Unclassified Sporadic cancers
234_TYR GLN VAR_045848 - Unclassified A sporadic cancer
235_ASN ASP VAR_047182 - Unclassified An adrenocortical carcinoma with no family history
236_TYR SER VAR_045194 rs730882026 Unclassified Sporadic cancers
237_MET VAL VAR_045199 rs730882004 Unclassified Sporadic cancers
238_CYS HIS VAR_045850 - Unclassified A sporadic cancer
239_ASN TYR VAR_045210 - Unclassified Sporadic cancers
240_SER THR VAR_045216 - Unclassified Sporadic cancers
241_SER THR VAR_047183 - Disease Li-Fraumeni syndrome (LFS) [MIM:151623]
242_CYS TYR VAR_045224 rs121912655 Unclassified A familial cancer not matching LFS
243_MET VAL VAR_045230 - Unclassified Sporadic cancers
244_GLY ALA VAR_047186 rs985033810 Unclassified Sporadic cancers
245_GLY ASN VAR_045854 - Unclassified Sporadic cancers
246_MET LYS VAR_045240 - Unclassified Sporadic cancers
247_ASN THR VAR_047189 - Unclassified Sporadic cancers
248_ARG PRO VAR_045246 rs11540652 Unclassified Sporadic cancers
249_ARG ASN VAR_045856 - Unclassified A sporadic cancer
250_PRO LEU VAR_047192 - Unclassified Sporadic cancers
251_ILE VAL VAR_045260 - Unclassified Sporadic cancers
252_LEU VAL VAR_045264 - Unclassified A sporadic cancer
253_THR PRO VAR_047193 - Unclassified Sporadic cancers
254_ILE ASP VAR_045859 - Unclassified Sporadic cancers
255_ILE VAL VAR_045279 - Unclassified Sporadic cancers
256_THR SER VAR_045283 - Unclassified Sporadic cancers
257_LEU VAL VAR_045286 - Unclassified Sporadic cancers
258_GLU LEU VAR_045860 - Unclassified A sporadic cancer
259_ASP ALA VAR_047194 - Unclassified A sporadic cancer
260_SER TYR VAR_045301 rs876658916 Unclassified Sporadic cancers
261_SER ARG VAR_045306 - Unclassified Sporadic cancers
262_GLY ASP VAR_047196 - Unclassified Sporadic cancers
263_ASN SER VAR_045314 - Unclassified A sporadic cancer
264_LEU VAL VAR_045319 - Unclassified A sporadic cancer
265_LEU ARG VAR_047197 - Unclassified Sporadic cancers
266_GLY VAL VAR_045326 rs193920774 Unclassified Sporadic cancers
267_ARG GLN VAR_045330 rs587780075 Disease Li-Fraumeni syndrome (LFS) [MIM:151623]
268_ASN PHE VAR_045864 - Unclassified A sporadic cancer
269_SER ILE VAR_047198 - Unclassified A sporadic cancer
270_PHE TYR VAR_045346 - Unclassified Sporadic cancers
271_GLU VAL VAR_047199 - Unclassified An osteosarcoma with no family history
272_VAL MET VAR_045354 rs121912657 Unclassified Sporadic cancers
273_ARG TYR VAR_045868 - Unclassified A sporadic cancer
274_VAL GLY VAR_047200 - Unclassified Sporadic cancers
275_CYS SER VAR_045365 - Unclassified Sporadic cancers
276_ALA VAL VAR_045371 - Unclassified Sporadic cancers
277_CYS TRP VAR_047201 - Unclassified Sporadic cancers
278_PRO PHE VAR_045869 - Unclassified Sporadic cancers
279_GLY TRP VAR_045379 - Unclassified Sporadic cancers
280_ARG SER VAR_045382 - Unclassified Sporadic cancers
281_ASP ASN VAR_047202 rs764146326 Disease Li-Fraumeni syndrome (LFS) [MIM:151623]
283_ARG SER VAR_045389 rs149633775 Unclassified A sporadic cancer
284_THR LYS VAR_045391 - Unclassified Sporadic cancers
285_GLU GLY VAR_045394 - Unclassified Sporadic cancers
286_GLU LEU VAR_045871 - Unclassified A sporadic cancer
287_GLU ALA VAR_047204 - Unclassified A sporadic cancer
288_ASN TYR VAR_045404 - Unclassified Sporadic cancers
289_LEU VAL VAR_045409 - Unclassified Sporadic cancers
290_ARG LEU VAR_045412 - Disease Li-Fraumeni syndrome (LFS) [MIM:151623]
291_LYS GLN VAR_047205 - Unclassified Sporadic cancers
292_LYS GLY VAR_045872 - Unclassified A sporadic cancer