PDB ID 2PMW     CHAIN B
Protein name Proprotein convertase subtilisin/kexin type 9
Uniprot Accession Q5SZQ2
The number of similar proteins 16
The number of binding states 5
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2PMW (CHAIN: B)
1 Q8NBP7  
2 Q8NBP7   Q59FQ1  
3 Q8NBP7   P01130  
4 Q8NBP7   3SQO   3SQO  
5 Q8NBP7   5VL7   5VL7  

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Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   SIPWNLERIT   PPRYRADEYQ   PPDGGSLVEV   YLLDTSIQSD   HREIEGRVMV   50
51   TDFENVPEED   GTRFHRQASK   CDSHGTHLAG   VVSGRDAGVA   KGASMRSLRV   100
101   LNCQGKGTVS   GTLIGLEFIR   KSQLVQPVGP   LVVLLPLAGG   YSRVLNAACQ   150
151   RLARAGVVLV   TAAGNFRDDA   CLYSPASAPE   VITVGATNAQ   DQPVTLGTLG   200
201   TNFGRCVDLF   APGEDIIGAS   SDCSTCFVSQ   SGTSQAAAHV   AGIAAMMLSA   250
251   EPELTLAELR   QRLIHFSAKD   VINEAWFPED   QRVLTPNLVA   ALPPSTHGAG   300
301   WQLFCRTVWS   AHSGPTRMAT   AVARCAPDEE   LLSCSSFSRS   GKRRGERMEA   350
351   QGGKLVCRAH   NAFGGEGVYA   IARCCLLPQA   NCSVHTAPPA   EASMGTRVHC   400
401   HQQGHVLTGC   SSHWEVEDLG   THKPPVLRPR   GQPNQCVGHR   EASIHASCCH   450
451   APGLECKVKE   HGIPAPQEQV   TVACEEGWTL   TGCSALPGTS   HVLGAYAVDN   500
501   TCVVRSRDVS   TTGSTSEGAV   TAVAICCRSR   HLAQASQELQ     550

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
153_SER ASN 8.3kJPN
chr1:55512254
-
- 0.0001 -
209_PRO LEU 8.3kJPN
chr1:55518053
-
- 0.0001 -
219_GLN GLU 8.3kJPN
chr1:55518082
rs778617372
- 0.0001 -
233_VAL ALA 8.3kJPN
chr1:55518363
-
- 0.0001 -
236_GLY SER 8.3kJPN
chr1:55518371
rs149489325
- 0.0001 -
237_ARG TRP gnomAD
chr1:55518374
rs148195424
- 0.000718598 -
237_ARG TRP 8.3kJPN
chr1:55518374
rs148195424
- 0.0001 -
241_VAL MET 8.3kJPN
chr1:55518386
rs147478188
- 0.0001 -
246_SER ASN 8.3kJPN
chr1:55518402
-
- 0.0001 -
248_ARG CYS 8.3kJPN
chr1:55518407
rs779824389
- 0.0002 -
253_LEU PHE gnomAD
chr1:55518422
rs72646508
- 0.000192791 -
263_GLY SER 8.3kJPN
chr1:55518452
rs200146448
- 0.007 -
264_THR ILE 8.3kJPN
chr1:55518456
rs201789841
- 0.0051 -
279_PRO THR gnomAD
chr1:55521701
rs72646509
- 0.000308363 -
298_ASN ASP gnomAD
chr1:55521758
rs575003139
- 0.000108556 -
310_VAL MET 8.3kJPN
chr1:55521794
rs1200999906
- 0.0001 -
323_CYS SER 8.3kJPN
chr1:55521834
rs1307302473
- 0.0001 -
354_ASN ILE ClinVar
chr1:55523068
rs1553137543
Likely pathogenic - Hypercholesterolemia, familial, 1 [MONDO:MONDO:0007750,MedGen:C0745103,OMIM:143890,Orphanet:391665]
357_ARG CYS gnomAD
chr1:55523076
rs148562777
- 0.00015117 -
357_ARG CYS 8.3kJPN
chr1:55523076
rs148562777
- 0.0001 -
367_ASP HIS gnomAD
chr1:55523106
rs141867978
- 0.000230776 -
374_ASP TYR ClinVar
chr1:55523127
rs137852912
Pathogenic/Likely pathogenic - Hypercholesterolemia, autosomal dominant, 3|Hypercholesterolemia, familial, 1 [MONDO:MONDO:0011369,MedGen:C1863551,OMIM:603776|MONDO:MONDO:0007750,MedGen:C0745103,OMIM:143890,Orphanet:391665]
374_ASP HIS ClinVar
chr1:55523127
rs137852912
Pathogenic - Hypercholesterolemia, familial, 1|Hypercholesterolemia, autosomal dominant, 3 [MONDO:MONDO:0007750,MedGen:C0745103,OMIM:143890,Orphanet:391665|MONDO:MONDO:0011369,MedGen:C1863551,OMIM:603776]
378_CYS TRP 8.3kJPN
chr1:55523141
rs776752113
- 0.0001 -
391_HIS ASN gnomAD
chr1:55523178
rs146471967
- 0.000162615 -
392_VAL MET ClinVar
chr1:55523181
rs1254346075
Pathogenic - Hypercholesterolemia, familial, 1 [MONDO:MONDO:0007750,MedGen:C0745103,OMIM:143890,Orphanet:391665]
412_ARG LYS 8.3kJPN
chr1:55523763
rs775522541
- 0.0001 -
417_HIS GLN gnomAD
chr1:55523779
rs143275858
- 0.000214927 -
424_ILE VAL 8.3kJPN
chr1:55523798
rs759250273
- 0.0092 -
425_ASN SER gnomAD
chr1:55523802
rs28362261
- 0.00122609 -
428_TRP TER 8.3kJPN
chr1:55523812
-
- 0.0007 -
443_ALA THR gnomAD
chr1:55523855
rs28362263
- 0.00719433 -
465_SER TRP ClinVar
chr1:55524211
-
Likely pathogenic - Hypercholesterolemia, autosomal dominant, 3 [MONDO:MONDO:0011369,MedGen:C1863551,OMIM:603776]
467_PRO LEU 8.3kJPN
chr1:55524217
-
- 0.0001 -
468_THR ALA ClinVar
chr1:55524219
rs1553137693
Pathogenic - Hypercholesterolemia, familial, 1 [MONDO:MONDO:0007750,MedGen:C0745103,OMIM:143890,Orphanet:391665]
469_ARG TRP gnomAD
chr1:55524222
rs141502002
- 0.00060473 -
471_ALA SER ClinVar
chr1:55524228
rs1553137699
Pathogenic - Hypercholesterolemia, familial, 1 [MONDO:MONDO:0007750,MedGen:C0745103,OMIM:143890,Orphanet:391665]
474_VAL ILE gnomAD
chr1:55524237
rs562556
- 0.856674 -
474_VAL ILE 8.3kJPN
chr1:55524237
rs562556
- 0.9687 -
495_ARG TRP 8.3kJPN
chr1:55524300
rs758999339
- 0.0001 -
496_ARG GLN gnomAD
chr1:55524304
rs139669564
- 0.000254051 -
499_ARG CYS gnomAD
chr1:55524312
rs201395805
- 0.000126901 -
499_ARG CYS 8.3kJPN
chr1:55524312
rs201395805
- 0.0002 -
504_GLY TRP 8.3kJPN
chr1:55525165
rs374455190
- 0.0001 -
510_ARG TRP 8.3kJPN
chr1:55525183
rs751649334
- 0.0001 -
514_ALA THR 8.3kJPN
chr1:55525195
rs1447116791
- 0.0001 -
522_ALA THR 8.3kJPN
chr1:55525219
rs777300852
- 0.0001 -
536_VAL ILE gnomAD
chr1:55525261
rs776367625
- 0.000138509 -
549_ARG PRO 8.3kJPN
chr1:55525301
-
- 0.0001 -
553_HIS ARG gnomAD
chr1:55525313
rs28362270
- 0.000732503 -
554_GLN GLU gnomAD
chr1:55525315
rs149311926
- 0.00017853 -
589_VAL MET 8.3kJPN
chr1:55527131
rs372586224
- 0.0002 -
591_HIS GLN gnomAD
chr1:55527139
rs529912877
- 0.000140526 -
592_ARG THR 8.3kJPN
chr1:55527141
-
- 0.0001 -
598_ALA THR gnomAD
chr1:55527158
rs367606156
- 0.000103727 -
598_ALA THR 8.3kJPN
chr1:55527158
rs367606156
- 0.0002 -
616_PRO LEU 8.3kJPN
chr1:55527213
rs755750316
- 0.0001 -
619_GLN PRO gnomAD
chr1:55527222
rs28362277
- 0.00096086 -
629_GLY ASP 8.3kJPN
chr1:55529064
rs1261496250
- 0.0007 -
636_SER ARG ClinVar
chr1:55529084
rs2100343401
Likely pathogenic - Hypercholesterolemia, autosomal dominant, 3 [MONDO:MONDO:0011369,MedGen:C1863551,OMIM:603776]
644_VAL ILE 8.3kJPN
chr1:55529108
rs143291739
- 0.0035 -
659_ARG GLY 8.3kJPN
chr1:55529153
rs147182054
- 0.0001 -
670_GLY GLU gnomAD
chr1:55529187
rs505151
- 0.947698 -
670_GLY GLU 8.3kJPN
chr1:55529187
rs505151
- 0.9528 -
675_VAL ILE 8.3kJPN
chr1:55529201
rs760981278
- 0.0001 -
680_ARG TRP gnomAD
chr1:55529216
rs533555352
- 0.000310126 -
680_ARG LEU 8.3kJPN
chr1:55529217
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.