PDB ID 2QKI CHAIND
Protein nameCOMPLEMENT C3
Uniprot Accession P01024
The number of similar proteins 10
The number of binding states 3
The number of binding partners 3
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
2QKI (CHAIN: D)
1 P01024 P01024
2 P01024
3 P01024 P01024 Q9Y279
Downdload
Format:
Molecule viewer
#binding
partners
  3
  2
  1
  0
Sequence information
1  SPMYSIITPN   ILRLESEETM   VLEAHDAQGD   VPVTVTVHDF   PGKKLVLSSE   50
51  KTVLTPATNH   MGNVTFTIPA   NREFKSEKGR   NKFVTVQATF   GTQVVEKVVL   100
101  VSLQSGYLFI   QTDKTIYTPG   STVLYRIFTV   NHKLLPVGRT   VMVNIENPEG   150
151  IPVKQDSLSS   QNQLGVLPLS   WDIPELVNMG   QWKIRAYYEN   SPQQVFSTEF   200
201  EVKEYVLPSF   EVIVEPTEKF   YYIYNEKGLE   VTITARFLYG   KKVEGTAFVI   250
251  FGIQDGEQRI   SLPESLKRIP   IEDGSGEVVL   SRKVLLDGVQ   NLRAEDLVGK   300
301  SLYVSATVIL   HSGSDMVQAE   RSGIPIVTSP   YQIHFTKTPK   YFKPGMPFDL   350
351  MVFVTNPDGS   PAYRVPVAVQ   GEDTVQSLTQ   GDGVAKLSIN   THPSQKPLSI   400
401  TVRTKKQELS   EAEQATRTMQ   ALPYSTVGNS   NNYLHLSVLR   TELRPGETLN   450
451  VNFLLRMDRA   HEAKIRYYTY   LIMNKGRLLK   AGRQVREPGQ   DLVVLPLSIT   500
501  TDFIPSFRLV   AYYTLIGASG   QREVVADSVW   VDVKDSCVGS   LVVKSGQSED   550
551  RQPVPGQQMT   LKIEGDHGAR   VVLVAVDKGV   FVLNKKNKLT   QSKIWDVVEK   600
601  ADIGCTPGSG   KDYAGVFSDA   GLTFTSSSGQ   QTAQRAELQC   PQP        650
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
80_ARG GLY VAR_001983 rs2230199 Polymorphism -
133_LYS GLN VAR_070941 rs147859257 Disease Macular degeneration, age-related, 9 (ARMD9) [MIM:611378]
447_GLU ASP VAR_020262 rs11569422 Polymorphism -
527_ASP ASN VAR_001985 - Disease Complement component 3 deficiency (C3D) [MIM:613779]
570_ARG TRP VAR_063214 rs771353792 Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
581_PHE VAL VAR_063654 - Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]