PDB ID 2QNA     CHAIN A
Protein name Importin subunit beta-1
Uniprot Accession Q14974
The number of similar proteins 8
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2QNA (CHAIN: A)
1 O95149  
2 Monomeric state
3 O95863  
4 P52292  
5 Q12772   Q12772  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   SPELIPQLVA   NVTNPNSTEH   MKESTLEAIG   YICQDIDPEQ   LQDKSNEILT   50
51   AIIQGMRKEE   PSNNVKLAAT   NALLNSLEFT   KANFDKESER   HFIMQVVCEA   100
101   TQCPDTRVRV   AALQNLVKIM   SLYYQYMETY   MGPALFAITI   EAMKSDIDEV   150
151   ALQGIEFWSN   VCDEEMDLAI   EASEAAEQGR   PPEHTSKFYA   KGALQYLVPI   200
201   LTQTLTKQDE   NDDDDDWNPC   KAAGVCLMLL   ATCCEDDIVP   HVLPFIKEHI   250
251   KNPDWRYRDA   AVMAFGCILE   GPEPSQLKPL   VIQAMPTLIE   LMKDPSVVVR   300
301   DTAAWTVGRI   CELLPEAAIN   DVYLAPLLQC   LIEGLSAEPR   VASNVCWAFS   350
351   SLAEAAYEAA   DVADDQEEPA   TYCLSSSFEL   IVQKLLETTD   RPDGHQNNLR   400
401   SSAYESLMEI   VKNSAKDCYP   AVQKTTLVIM   ERLQQVLQME   SHIQSTSDRI   450
451   QFNDLQSLLC   ATLQNVLRKV   QHQDALQISD   VVMASLLRMF   QSTAGSGGVQ   500
501   EDALMAVSTL   VEVLGGEFLK   YMEAFKPFLG   IGLKNYAEYQ   VCLAAVGLVG   550
551   DLCRALQSNI   IPFCDEVMQL   LLENLGNENV   HRSVKPQILS   VFGDIALAIG   600
601   GEFKKYLEVV   LNTLQQASQA   QVDKSDYDMV   DYLNELRESC   LEAYTGIVQG   650
651   LKGDQENVHP   DVMLVQPRVE   FILSFIDHIA   GDEDHTDGVV   ACAAGLIGDL   700
701   CTAFGKDVLK   LVEARPMIHE   LLTEGRRSKT   NKAKTLATWA   TKELRKLKNQ   750
751   GLTRVDSSGR   IV         800

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
181_MET LEU 8.3kJPN
chr17:45735931 		-
- 0.0001 -
205_THR ILE 8.3kJPN
chr17:45736004 		-
- 0.0001 -
381_ARG GLN 8.3kJPN
chr17:45745694 		rs776002778
- 0.0001 -
462_ALA THR 8.3kJPN
chr17:45747203 		-
- 0.0002 -
487_VAL ILE gnomAD
chr17:45748110 		rs202234934
- 0.000115371 -
487_VAL ILE 8.3kJPN
chr17:45748110 		rs202234934
- 0.0001 -
553_VAL ILE 8.3kJPN
chr17:45750493 		-
- 0.0001 -
640_GLY ASP 8.3kJPN
chr17:45753781 		-
- 0.0001 -
770_THR SER 8.3kJPN
chr17:45755735 		-
- 0.0001 -
844_HIS TYR 8.3kJPN
chr17:45757935 		rs774190588
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.