PDB ID 2QTS     CHAIN A
Protein name Acid-sensing ion channel
Uniprot Accession Q1XA76
The number of similar proteins 40
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2QTS (CHAIN: A)
1 Q1XA76   Q1XA76  
2 Monomeric state
3 P60514  
4 G9I930   G9I929  
5 Q1XA76   Q1XA76   P60514   P60514  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   STLHGISHIF   SYERLSLKRV   VWALCFMGSL   ALLALVCTNR   IQYYFLYPHV   50
51   TKLDEVAATR   LTFPAVTFCN   LNEFRFSRVT   KNDLYHAGEL   LALLNNRYEI   100
101   PDTQTADEKQ   LEILQDKANF   RNFKPKPFNM   LEFYDRAGHD   IREMLLSCFF   150
151   RGEQCSPEDF   KVVFTRYGKC   YTFNAGQDGK   PRLITMKGGT   GNGLEIMLDI   200
201   QQDEYLPVWG   ETDETSFEAG   IKVQIHSQDE   PPLIDQLGFG   VAPGFQTFVS   250
251   CQEQRLIYLP   PPWGDCKATT   GDSEFYDTYS   ITACRIDCET   RYLVENCNCR   300
301   MVHMPGDAPY   CTPEQYKECA   DPALDFLVEK   DNEYCVCEMP   CNVTRYGKEL   350
351   SMVKIPSKAS   AKYLAKKYNK   SEQYIGENIL   VLDIFFEALN   YETIEQKKAY   400
401   EVAGLLGDIG   GQMGLFIGAS   ILTVLELFDY   AYEVIKHR     450

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
49_LEU VAL 8.3kJPN
chr12:50452691
-
- 0.0001 -
65_ARG HIS 8.3kJPN
chr12:50452740
-
- 0.0001 -
79_ASP ASN 8.3kJPN
chr12:50452781
rs780194390
- 0.0001 -
91_VAL ILE 8.3kJPN
chr12:50452817
rs1306904297
- 0.0001 -
98_GLU LYS 8.3kJPN
chr12:50452838
rs773503565
- 0.0001 -
151_LYS GLU 8.3kJPN
chr12:50453627
-
- 0.0001 -
156_ARG HIS 8.3kJPN
chr12:50453643
rs766103987
- 0.0001 -
197_THR MET 8.3kJPN
chr12:50471024
rs755008406
- 0.0001 -
201_GLY SER 8.3kJPN
chr12:50471035
rs746113466
- 0.0001 -
213_GLY ASP 8.3kJPN
chr12:50471072
rs765919956
- 0.0001 -
215_THR MET 8.3kJPN
chr12:50471078
rs373616682
- 0.0001 -
302_ASP ASN 8.3kJPN
chr12:50472273
rs774054780
- 0.0001 -
315_THR MET 8.3kJPN
chr12:50472313
rs200645931
- 0.0004 -
361_VAL MET gnomAD
chr12:50473717
rs199923697
- 0.000203564 -
410_PHE VAL 8.3kJPN
chr12:50474306
-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.