PDB ID 3B2V CHAIN A
Protein name Epidermal growth factor receptor
Uniprot Accession P00533
The number of similar proteins 19
The number of binding states 7
The number of binding partners 6
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
3B2V (CHAIN: A)
1 3B2V   3B2V  
2 Monomeric state
3 3QWQ  
4 P01133  
5 E0ACT6  
6 P00533   P01133  
7 4KRO   4KRO  

4KRO  
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partners
  3
  2
  1
  0
Sequence information
1   LEEKKVCQGT   SNKLTQLGTF   EDHFLSLQRM   FNNCEVVLGN   LEITYVQRNY   50
51   DLSFLKTIQE   VAGYVLIALN   TVERIPLENL   QIIRGNMYYE   NSYALAVLSN   100
101   YDANKTGLKE   LPMRNLQEIL   HGAVRFSNNP   ALCNVESIQW   RDIVSSDFLS   150
151   NMSMDFQNHL   GSCQKCDPSC   PNGSCWGAGE   ENCQKLTKII   CAQQCSGRCR   200
201   GKSPSDCCHN   QCAAGCTGPR   ESDCLVCRKF   RDEATCKDTC   PPLMLYNPTT   250
251   YQMDVNPEGK   YSFGATCVKK   CPRNYVVTDH   GSCVRACGAD   SYEMEEDGVR   300
301   KCKKCEGPCR   KVCNGIGIGE   FKDSLSINAT   NIKHFKNCTS   ISGDLHILPV   350
351   AFRGDSFTHT   PPLDPQELDI   LKTVKEITGF   LLIQAWPENR   TDLHAFENLE   400
401   IIRGRTKQHG   QFSLAVVSLN   ITSLGLRSLK   EISDGDVIIS   GNKNLCYANT   450
451   INWKKLFGTS   GQKTKIISNR   GENSCKATGQ   VCHALCSPEG   CWGPEPRDCV   500
501   SCRNVSRGRE   CVDKCNLLEG   EPREFVENSE   CIQCHPECLP   QAMNITCTGR   550
551   GPDNCIQCAH   YIDGPHCVKT   CPAGVMGENN   TLVWKYADAG   HVCHLCHPNC   600
601   TYGCTGPGLE   GCPTNGPKHH   HHHH       650
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
239_THR PRO ClinVar
chr7:55221743
rs1057519829 Likely pathogenic Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]
242_PRO ARG VAR_019294 rs17336639 Polymorphism -
265_ALA VAL ClinVar
chr7:55221822
rs149840192 Likely pathogenic Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]
265_ALA THR ClinVar
chr7:55221821
rs769696078 Likely pathogenic Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]
265_ALA ASP ClinVar
chr7:55221822
rs149840192 Likely pathogenic Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]
302_CYS PHE ClinVar
chr7:55223610
rs886037891 Pathogenic Cowden syndrome 1 [MedGen:CN072330,OMIM:158350]
306_GLU LYS ClinVar
chr7:55223621
rs139429793 Pathogenic Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]
404_GLY ASP ClinVar
chr7:55225431
rs606231253 Pathogenic Inflammatory skin and bowel disease, neonatal, 2 [MedGen:C4015130,OMIM:616069]
468_SER GLY ClinVar
chr7:55228007
rs1057519760 Likely pathogenic Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]
497_ARG LYS VAR_019295 rs2227983 Polymorphism -
522_PRO SER ClinVar
chr7:55231430
rs1057519830 Likely pathogenic Head and Neck Neoplasms [MeSH:D006258,MedGen:C0018671,Orphanet:ORPHA290849]
574_GLY VAL ClinVar
chr7:55233043
rs139236063 Likely pathogenic Brainstem glioma [Human Phenotype Ontology:HP:0010796,MedGen:C0677865]; Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]
574_GLY ALA ClinVar
chr7:55233043
rs139236063 Likely pathogenic Brainstem glioma [Human Phenotype Ontology:HP:0010796,MedGen:C0677865]; Glioblastoma [MeSH:D005909,MedGen:C0017636,Orphanet:ORPHA360,SNOMED CT:63634009]; Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MeSH:D001932,MedGen:C0006118,SNOMED CT:126952004]
610_GLU TER ClinVar
chr7:55238010
rs909905659 Likely pathogenic Cerebral arteriovenous malformation [Human Phenotype Ontology:HP:0002408,MedGen:C0917804,OMIM:108010,SNOMED CT:234142008]