PDB ID 3BJC     CHAIN A
Protein name cGMP-specific 3',5'-cyclic phosphodiesterase
Uniprot Accession O76074
The number of similar proteins 1
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3BJC (CHAIN: A)
1 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   GSHMERAGPS   FGQQRQQQQP   QQQKQQQRDQ   DSVEAWLDDH   WDFTFSYFVR   50
51   KATREMVNAW   FAERVHTIPV   CKEGIRGHTE   SCSCPLQQSP   RADNSVPGTP   100
101   TRKISASEFD   RPLRPIVVKD   SEGTVSFLSD   SEKKEQMPLT   PPRFDHDEGD   150
151   QCSRLLELVK   DISSHLDVTA   LCHKIFLHIH   GLISADRYSL   FLVCEDSSND   200
201   KFLISRLFDV   AEGSTLEEVS   NNCIRLEWNK   GIVGHVAALG   EPLNIKDAYE   250
251   DPRFNAEVDQ   ITGYKTQSIL   CMPIKNHREE   VVGVAQAINK   KSGNGGTFTE   300
301   KDEKDFAAYL   AFCGIVLHNA   QLYETSLLEN   KRNQVLLDLA   SLIFEEQQSL   350
351   EVILKKIAAT   IISFMQVQKC   TIFIVDEDCS   DSFSSVFHME   CEELEKSSDT   400
401   LTREHDANKI   NYMYAQYVKN   TMEPLNIPDV   SKDKRFPWTT   ENTGNVNQQC   450
451   IRSLLCTPIK   NGKKNKVIGV   CQLVNKMEEN   TGKVKPFNRN   DEQFLEAFVI   500
501   FCGLGIQNTQ   MYEAVERAMA   KQMVTLEVLS   YHASAAEEET   RELQSLAAAV   550
551   VPSAQTLKIT   DFSFSDFELS   DLETALCTIR   MFTDLNLVQN   FQMKHEVLCR   600
601   WILSVKKNYR   KNVAYHNWRH   AFNTAQCMFA   ALKAGKIQNK   LTDLEILALL   650
651   IAALSHDLDH   RGVNNSYIQR   SEHPLAQLYC   HSIMEHHHFD   QCLMILNSPG   700
701   NQILSGLSIE   EYKTTLKIIK   QAILATDLAL   YIKRRGEFFE   LIRKNQFNLE   750
751   DPHQKELFLA   MLMTACDLSA   ITKPWPIQQR   IAELVATEFF   DQGDRERKEL   800
801   NIEPTDLMNR   EKKNKIPSMQ   VGFIDAICLQ   LYEALTHVSE   DCFPLLDGCR   850
851   KNRQKWQALA   EQQEKMLING   ESGQAKRN       900

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
562_SER ASN 8.3kJPN
chr4:120446798 		rs778103038
- 0.0002 -
577_ARG GLN 8.3kJPN
chr4:120446753 		rs569083571
- 0.0004 -
577_ARG TRP 8.3kJPN
chr4:120446754 		rs182361575
- 0.0001 -
625_MET THR gnomAD
chr4:120442121 		rs199872206
- 0.000128247 -
641_LEU PRO gnomAD
chr4:120440278 		rs116396619
- 0.00103949 -
740_ARG LYS gnomAD
chr4:120427058 		rs139979143
- 0.00414276 -
758_MET THR 8.3kJPN
chr4:120425749 		-
- 0.0001 -
777_ARG GLN 8.3kJPN
chr4:120425692 		rs374510132
- 0.0002 -
788_ASP TYR 8.3kJPN
chr4:120423780 		rs201756535
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

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