PDB ID 3BU6 CHAINA
Protein nameINSULIN RECEPTOR SUBUNIT BETA
Uniprot Accession P06213
The number of similar proteins 13
The number of binding states 5
The number of binding partners 4
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
3BU6 (CHAIN: A)
1 Monomeric state
2 Q14449
3 Q9Z200
4 P06213
5 P06213 P18031
Downdload
Format:
Molecule viewer
#binding
partners
  2
  1
  0
Sequence information
1  VFPSSVYVPD   EWEVSREKIT   LLRELGQGSF   GMVYEGNARD   IIKGEAETRV   50
51  AVKTVNESAS   LRERIEFLNE   ASVMKGFTCH   HVVRLLGVVS   KGQPTLVVME   100
101  LMAHGDLKSY   LRSLRPEAEN   NPGRPPPTLQ   EMIQMAAEIA   DGMAYLNAKK   150
151  FVHRDLAARN   CMVAHDFTVK   IGDFGMTRDI   XETDXXRKGG   KGLLPVRWMA   200
201  PESLKDGVFT   TSSDMWSFGV   VLWEITSLAE   QPYQGLSNEQ   VLKFVMDGGY   250
251  LDQPDNCPER   VTDLMRMCWQ   FNPNMRPTFL   EIVNLLKDDL   HPSFPEVSFF   300
301  HSEENK                                                     350
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
993_ARG GLN VAR_004092 rs121913148 Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
996_ILE PHE VAR_015922 - Polymorphism -
1008_GLY VAL VAR_004093 rs121913135 Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1028_ALA VAL VAR_015923 - Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1038_LEU VAL VAR_041432 rs56395521 Polymorphism -
1048_ALA ASP VAR_004094 - Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1068_LYS GLU VAR_015924 rs909008899 Polymorphism -
1092_ARG TRP VAR_015925 - Disease Leprechaunism (LEPRCH) [MIM:246200]
1116_ILE THR VAR_015926 - Disease Rabson-Mendenhall syndrome (RMS) [MIM:262190]
1131_ARG TRP VAR_015928 rs111993466 Disease Rabson-Mendenhall syndrome (RMS) [MIM:262190]
1134_ALA THR VAR_004095 rs121913139 Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1135_ALA GLU VAR_004096 rs121913154 Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1153_MET ILE VAR_004097 rs121913157 Polymorphism -
1164_ARG GLN VAR_004098 rs121913150 Disease Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]
1174_ARG TRP VAR_015930 - Disease Leprechaunism (LEPRCH) [MIM:246200]
1178_PRO LEU VAR_004099 - Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1179_GLU LYS VAR_015932 - Disease Leprechaunism (LEPRCH) [MIM:246200]
1193_TRP LEU VAR_004100 rs52800171 Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1200_TRP SER VAR_004101 rs121913140 Disease Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]
1255_THR ALA VAR_041433 rs55875349 Polymorphism -