PDB ID 3C5W     CHAIN P
Protein name PP2A-specific methylesterase PME-1
Uniprot Accession Q9Y570
The number of similar proteins 2
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3C5W (CHAIN: P)
1 P67775  
2 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   GSHMRDFSPV   PWSQYFESME   DVEVENETGK   DTFRVYKSGS   EGPVLLLLHG   50
51   GGHSALSWAV   FTAAIISRVQ   CRIVALDLRS   HGETKVKNPE   DLSAETMAKD   100
101   VGNVVEAMYG   DLPPPIMLIG   HAMGGAIAVH   TASSNLVPSL   LGLCMIDVVE   150
151   GTAMDALNSM   QNFLRGRPKT   FKSLENAIEW   SVKSGQIRNL   ESARVSMVGQ   200
201   VKQCEGKPYT   WRIELAKTEK   YWDGWFRGLS   NLFLSCPIPK   LLLLAGVDRL   250
251   DKDLTIGQMQ   GKFQMQVLPQ   CGHAVHEDAP   DKVAEAVATF   LIRHRFAEPI   300
301   GGFQCVFPGC           350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
39_ARG TRP gnomAD
chr11:73914786 		rs199766005
- 0.000117766 -
48_GLN HIS 8.3kJPN
chr11:73914815 		rs201971289
- 0.0002 -
61_GLU LYS 8.3kJPN
chr11:73914852 		-
- 0.0001 -
72_SER ASN gnomAD
chr11:73915417 		rs369439716
- 0.000225144 -
170_LEU ARG 8.3kJPN
chr11:73941400 		-
- 0.0001 -
203_LYS THR 8.3kJPN
chr11:73942011 		rs1046459001
- 0.0002 -
212_ILE VAL 8.3kJPN
chr11:73942037 		rs183405413
- 0.0001 -
229_VAL ILE 8.3kJPN
chr11:73946986 		-
- 0.0001 -
231_MET VAL 8.3kJPN
chr11:73946992 		rs572746963
- 0.0001 -
238_CYS SER 8.3kJPN
chr11:73950180 		rs190849735
- 0.0043 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.