PDB ID 3CAF CHAIN A
Protein name Fibroblast growth factor receptor 2
Uniprot Accession P21802
The number of similar proteins 6
The number of binding states 4
The number of binding partners 4
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
3CAF (CHAIN: A)
1 P21802  
2 Monomeric state
3 4WV1   4WV1  
4 P21802   P05230  

P05230  
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partners
  2
  1
  0
Sequence information
1   NKRAPYWTNT   EKMEKRLHAV   PAANTVKFRC   PAGGNPMPTM   RWLKNGKEFK   50
51   QEHRIGGYKV   RNQHWSLIME   SVVPSDKGNY   TCVVENEYGS   INHTYHLDVV   100
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
166_LEU SER ClinVar
chr8:38285566
rs397515481 Pathogenic Hartsfield syndrome [MedGen:C1845146,OMIM:615465,Orphanet:ORPHA2117]
168_ALA SER ClinVar
chr8:38285561
rs121909630 Pathogenic Hypogonadotropic hypogonadism 2 with anosmia [MedGen:C4016104]
172_ALA PHE VAR_017259 - Disease Pfeiffer syndrome (PS) [MIM:101600]
186_MET THR VAR_017260 rs755793 Polymorphism -
190_ARG CYS ClinVar
chr8:38285495
rs863223331 Pathogenic Kallmann syndrome 2 [MedGen:C1563720,OMIM:147950]
192_LEU SER ClinVar
chr8:38285488
rs869025669 Pathogenic Hartsfield syndrome [MedGen:C1845146,OMIM:615465,Orphanet:ORPHA2117]
203_ARG CYS VAR_036380 - Unclassified Breast cancer samples
210_ARG CYS ClinVar
chr8:38283760
rs1554564353 Likely pathogenic Kallmann syndrome 2 [MedGen:C1563720,OMIM:147950]