PDB ID 3KWQ     CHAIN C
Protein name Histone H2A
Uniprot Accession Q6AZJ8
The number of similar proteins 389
The number of binding states 23
The number of binding partners 13

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   AKTRSSRAGL   QFPVGRVHRL   LRKGNYAERV   GAGAPVYLAA   VLEYLTAEIL   50
51   ELAGNAARDN   KKTRIIPRHL   QLAVRNDEEL   NKLLGRVTIA   QGGVLPNIQS   100
101   VLLPKKT           150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
14_ALA GLY ClinVar
chr6:27833176 		rs890521687
Likely pathogenic - Multiple myeloma [Human Phenotype Ontology:HP:0006775,MONDO:MONDO:0009693,MeSH:D009101,MedGen:C0026764,OMIM:254500,Orphanet:29073,Orphanet:85443]
14_ALA VAL gnomAD
chr1:228645475 		rs942855
- 0.000198165 -
14_ALA VAL 8.3kJPN
chr1:228645475 		rs942855
- 0.0001 -
14_ALA VAL 8.3kJPN
chr6:26199428 		rs773531178
- 0.0001 -
14_ALA THR 8.3kJPN
chr6:27100893 		rs200399044
- 0.0005 -
14_ALA THR 8.3kJPN
chr6:27806075 		rs1006888623
- 0.001 -
15_LYS ARG 8.3kJPN
chr1:149859420 		rs1553760178
- 0.0004 -
15_LYS ARG 8.3kJPN
chr6:27806071 		-
- 0.0004 -
16_THR PRO 8.3kJPN
chr6:26217251 		-
- 0.0001 -
18_SER TER 8.3kJPN
chr1:228645463 		rs754510222
- 0.0001 -
19_SER PHE gnomAD
chr6:27114966 		rs770606777
- 0.000107462 -
19_SER PHE gnomAD
chr6:27776046 		rs143049396
- 0.000582671 -
19_SER ALA 8.3kJPN
chr6:25726698 		rs761780090
- 0.0001 -
19_SER PRO 8.3kJPN
chr6:27100908 		-
- 0.0001 -
19_SER PHE 8.3kJPN
chr6:27833191 		rs184589037
- 0.0017 -
20_ARG TRP 8.3kJPN
chr6:26199411 		rs763562699
- 0.0001 -
20_ARG GLN 8.3kJPN
chr6:27114969 		rs769300562
- 0.0001 -
24_GLN TER 8.3kJPN
chr6:26199399 		rs140533379
- 0.0001 -
25_PHE TYR gnomAD
chr6:26033720 		rs145310776
- 0.000218744 -
25_PHE LEU 8.3kJPN
chr6:26033721 		-
- 0.0001 -
25_PHE LEU 8.3kJPN
chr6:26217278 		-
- 0.0001 -
25_PHE LEU 8.3kJPN
chr6:27114985 		-
- 0.0001 -
26_PRO SER 8.3kJPN
chr6:25726677 		rs1014929277
- 0.0001 -
26_PRO SER 8.3kJPN
chr6:26033718 		rs767532920
- 0.0001 -
31_HIS GLN 8.3kJPN
chr11:118966009 		-
- 0.0001 -
32_ARG TER 8.3kJPN
chr6:27806021 		-
- 0.0001 -
32_ARG LEU 8.3kJPN
chr6:27833230 		-
- 0.0001 -
33_LEU VAL 8.3kJPN
chr6:27860828 		-
- 0.0001 -
35_ARG CYS gnomAD
chr6:27833238 		rs576189710
- 0.000171343 -
35_ARG HIS 8.3kJPN
chr6:25726649 		rs371440858
- 0.0001 -
35_ARG CYS 8.3kJPN
chr6:27100956 		rs772693242
- 0.0001 -
35_ARG PRO 8.3kJPN
chr6:27833239 		-
- 0.0002 -
36_LYS MET 8.3kJPN
chr6:27833242 		-
- 0.0001 -
37_GLY SER gnomAD
chr6:26033685 		rs369599740
- 0.000139223 -
37_GLY SER 8.3kJPN
chr1:149858636 		rs782788423
- 0.0001 -
37_GLY ARG 8.3kJPN
chr6:25726644 		rs189327307
- 0.0001 -
37_GLY SER 8.3kJPN
chr6:27860816 		rs201009000
- 0.0001 -
38_ASN SER 8.3kJPN
chr6:27115023 		rs988081913
- 0.0001 -
39_TYR CYS gnomAD
chr6:27115026 		rs765177021
- 0.000242689 -
39_TYR CYS 8.3kJPN
chr6:27776106 		rs754867249
- 0.0001 -
40_ALA VAL 8.3kJPN
chr1:149858646 		rs974659430
- 0.0001 -
40_ALA SER 8.3kJPN
chr1:149859346 		-
- 0.0001 -
41_GLU LYS 8.3kJPN
chr6:27100974 		-
- 0.0001 -
42_ARG LEU gnomAD
chr6:26199344 		rs201200903
- 0.000741591 -
42_ARG LEU gnomAD
chr6:27782391 		rs774407719
- 0.000148075 -
42_ARG GLN 8.3kJPN
chr6:25726628 		rs762868475
- 0.0001 -
43_VAL LEU 8.3kJPN
chr6:27860798 		rs549660103
- 0.0001 -
45_ALA SER gnomAD
chr6:26033661 		rs201159814
- 0.000171139 -
47_ALA GLU gnomAD
chr6:27805975 		rs149494377
- 0.0124443 -
47_ALA VAL 8.3kJPN
chr6:27782376 		rs200522974
- 0.0001 -
47_ALA SER 8.3kJPN
chr6:27782377 		rs1250781403
- 0.0001 -
47_ALA GLU 8.3kJPN
chr6:27805975 		rs149494377
- 0.0599 -
48_PRO ARG gnomAD
chr1:228645373 		rs143327597
- 0.000233117 -
48_PRO LEU 8.3kJPN
chr6:25726610 		rs1417126640
- 0.0001 -
48_PRO SER 8.3kJPN
chr6:27776132 		-
- 0.0001 -
49_VAL LEU gnomAD
chr6:26199324 		rs142347437
- 0.000570476 -
49_VAL LEU 8.3kJPN
chr1:149859319 		rs782428337
- 0.0002 -
50_TYR CYS 8.3kJPN
chr6:26199320 		rs776773287
- 0.0001 -
50_TYR PHE 8.3kJPN
chr6:27115059 		-
- 0.0001 -
50_TYR CYS 8.3kJPN
chr6:27805966 		rs544484889
- 0.0001 -
51_LEU ARG gnomAD
chr6:26199317 		rs147678711
- 0.000298938 -
51_MET VAL 8.3kJPN
chr1:149858678 		rs201477575
- 0.0002 -
52_ALA GLY 8.3kJPN
chr6:25726598 		rs375336327
- 0.0001 -
53_ALA VAL gnomAD
chr6:27805957 		rs139301244
- 0.000401977 -
53_ALA VAL gnomAD
chr6:27833293 		rs141399242
- 0.000131374 -
53_ALA VAL 8.3kJPN
chr1:228645358 		rs564487637
- 0.0001 -
53_ALA GLY 8.3kJPN
chr6:26199311 		-
- 0.0008 -
53_ALA GLY 8.3kJPN
chr6:27782358 		-
- 0.0001 -
55_LEU PHE 8.3kJPN
chr6:26199304 		-
- 0.0001 -
55_LEU VAL 8.3kJPN
chr6:26199306 		rs755825653
- 0.0028 -
57_TYR SER 8.3kJPN
chr6:26033624 		-
- 0.0005 -
57_TYR SER 8.3kJPN
chr6:26124633 		-
- 0.0002 -
59_THR ILE 8.3kJPN
chr6:26033618 		rs545768553
- 0.0001 -
59_THR ALA 8.3kJPN
chr6:27805940 		-
- 0.0003 -
60_ALA PRO gnomAD
chr6:27833313 		rs368720914
- 0.000326184 -
61_GLU TER 8.3kJPN
chr1:149859283 		-
- 0.0001 -
61_GLU ASP 8.3kJPN
chr6:27833318 		-
- 0.0001 -
62_ILE VAL 8.3kJPN
chr1:149859280 		rs1559775930
- 0.0001 -
66_ALA VAL 8.3kJPN
chr6:26033597 		-
- 0.0001 -
66_ALA THR 8.3kJPN
chr6:26033598 		rs1459697118
- 0.0001 -
66_ALA VAL 8.3kJPN
chr6:27115107 		rs770769479
- 0.0001 -
66_ALA THR 8.3kJPN
chr6:27776186 		-
- 0.0001 -
67_GLY CYS 8.3kJPN
chr6:27782317 		-
- 0.0001 -
68_ASN SER gnomAD
chr12:14927610 		rs201674611
- 0.000159125 -
70_ALA THR gnomAD
chr6:27805907 		rs146210589
- 0.00011134 -
71_ARG HIS 8.3kJPN
chr6:25726541 		rs771578160
- 0.0001 -
71_ARG HIS 8.3kJPN
chr6:26033582 		-
- 0.0001 -
73_ASN LYS gnomAD
chr6:27805896 		rs371861857
- 0.000405586 -
73_ASN LYS 8.3kJPN
chr1:228645297 		rs201001912
- 0.0001 -
73_ASN LYS 8.3kJPN
chr6:27805896 		rs371861857
- 0.0029 -
73_ASN LYS 8.3kJPN
chr11:118965883 		rs780380122
- 0.0001 -
76_THR ILE 8.3kJPN
chr6:27115137 		-
- 0.0001 -
77_ARG CYS 8.3kJPN
chr6:26199240 		-
- 0.0001 -
77_ARG HIS 8.3kJPN
chr6:27805885 		rs746824735
- 0.0001 -
80_PRO SER 8.3kJPN
chr1:228645278 		-
- 0.0002 -
80_PRO THR 8.3kJPN
chr12:14927645 		-
- 0.0001 -
82_HIS TYR 8.3kJPN
chr12:14927651 		-
- 0.0001 -
83_LEU PHE 8.3kJPN
chr6:27782269 		rs1391700905
- 0.0001 -
84_GLN GLU 8.3kJPN
chr6:25726503 		-
- 0.0001 -
84_GLN TER 8.3kJPN
chr6:26199219 		rs770480882
- 0.0001 -
84_GLN TER 8.3kJPN
chr6:27115160 		rs143700242
- 0.0001 -
86_ALA SER 8.3kJPN
chr1:149858783 		-
- 0.0001 -
87_ILE VAL gnomAD
chr6:25726494 		rs146789964
- 0.000182956 -
87_ILE THR 8.3kJPN
chr6:27860665 		-
- 0.0001 -
88_ARG LEU 8.3kJPN
chr1:228645253 		-
- 0.0001 -
88_ARG HIS 8.3kJPN
chr6:27805852 		-
- 0.0001 -
89_ASN THR 8.3kJPN
chr12:14927673 		-
- 0.0001 -
93_LEU VAL gnomAD
chr6:26199192 		rs139406782
- 0.000111336 -
94_ASN HIS 8.3kJPN
chr6:27776270 		-
- 0.0001 -
96_LEU PHE 8.3kJPN
chr6:25726467 		rs1219098411
- 0.0001 -
97_LEU VAL 8.3kJPN
chr6:27805826 		-
- 0.0001 -
97_LEU PRO 8.3kJPN
chr6:27860635 		-
- 0.0001 -
99_LYS ARG 8.3kJPN
chr6:27101149 		rs753284856
- 0.0001 -
100_VAL ALA 8.3kJPN
chr6:25726454 		-
- 0.0001 -
100_VAL ILE 8.3kJPN
chr6:27782218 		rs1431545616
- 0.0001 -
109_PRO SER 8.3kJPN
chr6:27805790 		rs768172784
- 0.0001 -
110_ASN SER gnomAD
chr6:27833464 		rs144728921
- 0.00281915 -
110_ASN LYS gnomAD
chr12:14927737 		rs1823
- 0.000875058 -
112_GLN GLU 8.3kJPN
chr6:27805781 		-
- 0.0004 -
113_ALA VAL 8.3kJPN
chr12:14927745 		-
- 0.0001 -
114_VAL MET 8.3kJPN
chr6:27115250 		rs768852602
- 0.0007 -
920_THR MET 8.3kJPN
chr1:228645157 		rs764047633
- 0.0001 -
920_THR ALA 8.3kJPN
chr6:26124821 		-
- 0.0001 -
920_THR ASN 8.3kJPN
chr6:27860566 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.