PDB ID 3PRX CHAIN A
Protein name Complement C5
Uniprot Accession P01031
The number of similar proteins 7
The number of binding states 7
The number of binding partners 6
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
3PRX (CHAIN: A)
1 Q91132   D3JIB2  
2 Monomeric state
3 Q91132  
4 Q6GJP2  
5 A6QE84  
6 P13671  
7 5I5K   5I5K  
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partners
  3
  2
  1
  0
Sequence information
1   MGLLGILCFL   IFLGKTWGQE   QTYVISAPKI   FRVGASENIV   IQVYGYTEAF   50
51   DATISIKSYP   DKKFSYSSGH   VHLSSENKFQ   NSAILTIQPK   QLPGGQNPVS   100
101   YVYLEVVSKH   FSKSKRMPIT   YDNGFLFIHT   DKPVYTPDQS   VKVRVYSLND   150
151   DLKPAKRETV   LTFIDPEGSE   VDMVEEIDHI   GIISFPDFKI   PSNPRYGMWT   200
201   IKAKYKEDFS   TTGTAYFEVK   EYVLPHFSVS   IEPEYNFIGY   KNFKNFEITI   250
251   KARYFYNKVV   TEADVYITFG   IREDLKDDQK   EMMQTAMQNT   MLINGIAQVT   300
301   FDSETAVKEL   SYYSLEDLNN   KYLYIAVTVI   ESTGGFSEEA   EIPGIKYVLS   350
351   PYKLNLVATP   LFLKPGIPYP   IKVQVKDSLD   QLVGGVPVTL   NAQTIDVNQE   400
401   TSDLDPSKSV   TRVDDGVASF   VLNLPSGVTV   LEFNVKTDAP   DLPEENQARE   450
451   GYRAIAYSSL   SQSYLYIDWT   DNHKALLVGE   HLNIIVTPKS   PYIDKITHYN   500
501   YLILSKGKII   HFGTREKFSD   ASYQSINIPV   TQNMVPSSRL   LVYYIVTGEQ   550
551   TAELVSDSVW   LNIEEKCGNQ   LQVHLSPDAD   AYSPGQTVSL   NMATGMDSWV   600
601   ALAAVDSAVY   GVQRGAKKPL   ERVFQFLEKS   DLGCGAGGGL   NNANVFHLAG   650
651   LTFLTNANAD   DSQENDEPCK   EILRPRRTLQ   KKIEEIAAKY   KHSVVKKCCY   700
701   DGACVNNDET   CEQRAARISL   GPRCIKAFTE   CCVVASQLRA   NISHKDMQLG   750
751   RLHMKTLLPV   SKPEIRSYFP   ESWLWEVHLV   PRRKQLQFAL   PDSLTTWEIQ   800
801   GVGISNTGIC   VADTVKAKVF   KDVFLEMNIP   YSVVRGEQIQ   LKGTVYNYRT   850
851   SGMQFCVKMS   AVEGICTSES   PVIDHQGTKS   SKCVRQKVEG   SSSHLVTFTV   900
901   LPLEIGLHNI   NFSLETWFGK   EILVKTLRVV   PEGVKRESYS   GVTLDPRGIY   950
951   GTISRRKEFP   YRIPLDLVPK   TEIKRILSVK   GLLVGEILSA   VLSQEGINIL   1000
1001   THLPKGSAEA   ELMSVVPVFY   VFHYLETGNH   WNIFHSDPLI   EKQKLKKKLK   1050
1051   EGMLSIMSYR   NADYSYSVWK   GGSASTWLTA   FALRVLGQVN   KYVEQNQNSI   1100
1101   CNSLLWLVEN   YQLDNGSFKE   NSQYQPIKLQ   GTLPVEAREN   SLYLTAFTVI   1150
1151   GIRKAFDICP   LVKIDTALIK   ADNFLLENTL   PAQSTFTLAI   SAYALSLGDK   1200
1201   THPQFRSIVS   ALKREALVKG   NPPIYRFWKD   NLQHKDSSVP   NTGTARMVET   1250
1251   TAYALLTSLN   LKDINYVNPV   IKWLSEEQRY   GGGFYSTQDT   INAIEGLTEY   1300
1301   SLLVKQLRLS   MDIDVSYKHK   GALHNYKMTD   KNFLGRPVEV   LLNDDLIVST   1350
1351   GFGSGLATVH   VTTVVHKTST   SEEVCSFYLK   IDTQDIEASH   YRGYGNSDYK   1400
1401   RIVACASYKP   SREESSSGSS   HAVMDISLPT   GISANEEDLK   ALVEGVDQLF   1450
1451   TDYQIKDGHV   ILQLNSIPSS   DFLCVRFRIF   ELFEVGFLSP   ATFTVYEYHR   1500
1501   PDKQCTMFYS   TSNIKIQKVC   EGAACKCVEA   DCGQMQEELD   LTISAETRKQ   1550
1551   TACKPEIAYA   YKVSITSITV   ENVFVKYKAT   LLDIYKTGEA   VAEKDSEITF   1600
1601   IKKVTCTNAE   LVKGRQYLIM   GKEALQIKYN   FSFRYIYPLD   SLTWIEYWPR   1650
1651   DTTCSSCQAF   LANLDEFAED   IFLNGC       1700
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
145_VAL ILE VAR_038735 rs17216529 Polymorphism -
354_LEU MET VAR_048822 rs34552775 Polymorphism -
372_LYS ARG ClinVar
chr9:123785683
rs587776846 Pathogenic Leiner disease [MedGen:C0343047,OMIM:609536]
389_THR ILE VAR_023946 - Polymorphism -
449_ARG GLY VAR_038736 rs2230213 Polymorphism -
518_PHE SER VAR_001996 - Polymorphism -
802_VAL ILE VAR_014574 rs17611 Polymorphism -
885_ARG CYS VAR_071067 rs373359894 Polymorphism -
885_ARG HIS VAR_071068 rs56040400 Polymorphism -
928_ARG GLN VAR_038737 rs41309892 Polymorphism -
933_GLY VAL VAR_038738 rs41309902 Polymorphism -
966_ASP TYR VAR_048823 rs2230212 Polymorphism -
1033_ILE THR VAR_038739 rs41311881 Polymorphism -
1037_ASP ASN VAR_038740 rs41311883 Polymorphism -
1043_GLN LYS VAR_038741 rs41311887 Polymorphism -
1053_MET LEU VAR_014575 rs17609 Polymorphism -
1310_SER ASN VAR_014576 rs17610 Polymorphism -
1365_VAL ALA VAR_048824 rs16910245 Polymorphism -
1437_GLU ASP VAR_014577 rs17612 Polymorphism -
1476_ARG TER ClinVar
chr9:123725027
rs121909588 Pathogenic Leiner disease [MedGen:C0343047,OMIM:609536]