PDB ID 3PRX     CHAIN A
Protein name Complement C5
Uniprot Accession P01031
The number of similar proteins 11
The number of binding states 10
The number of binding partners 9

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3PRX (CHAIN: A)
1 Q91132   D3JIB2  
2 Monomeric state
3 Q91132  
4 P01031  
5 Q6GJP2  
6 A6QE84  
7 P13671  
8 5I5K   5I5K  
9 P01031   7AD6  
10 P01031   7AD7  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MGLLGILCFL   IFLGKTWGQE   QTYVISAPKI   FRVGASENIV   IQVYGYTEAF   50
51   DATISIKSYP   DKKFSYSSGH   VHLSSENKFQ   NSAILTIQPK   QLPGGQNPVS   100
101   YVYLEVVSKH   FSKSKRMPIT   YDNGFLFIHT   DKPVYTPDQS   VKVRVYSLND   150
151   DLKPAKRETV   LTFIDPEGSE   VDMVEEIDHI   GIISFPDFKI   PSNPRYGMWT   200
201   IKAKYKEDFS   TTGTAYFEVK   EYVLPHFSVS   IEPEYNFIGY   KNFKNFEITI   250
251   KARYFYNKVV   TEADVYITFG   IREDLKDDQK   EMMQTAMQNT   MLINGIAQVT   300
301   FDSETAVKEL   SYYSLEDLNN   KYLYIAVTVI   ESTGGFSEEA   EIPGIKYVLS   350
351   PYKLNLVATP   LFLKPGIPYP   IKVQVKDSLD   QLVGGVPVTL   NAQTIDVNQE   400
401   TSDLDPSKSV   TRVDDGVASF   VLNLPSGVTV   LEFNVKTDAP   DLPEENQARE   450
451   GYRAIAYSSL   SQSYLYIDWT   DNHKALLVGE   HLNIIVTPKS   PYIDKITHYN   500
501   YLILSKGKII   HFGTREKFSD   ASYQSINIPV   TQNMVPSSRL   LVYYIVTGEQ   550
551   TAELVSDSVW   LNIEEKCGNQ   LQVHLSPDAD   AYSPGQTVSL   NMATGMDSWV   600
601   ALAAVDSAVY   GVQRGAKKPL   ERVFQFLEKS   DLGCGAGGGL   NNANVFHLAG   650
651   LTFLTNANAD   DSQENDEPCK   EILRPRRTLQ   KKIEEIAAKY   KHSVVKKCCY   700
701   DGACVNNDET   CEQRAARISL   GPRCIKAFTE   CCVVASQLRA   NISHKDMQLG   750
751   RLHMKTLLPV   SKPEIRSYFP   ESWLWEVHLV   PRRKQLQFAL   PDSLTTWEIQ   800
801   GVGISNTGIC   VADTVKAKVF   KDVFLEMNIP   YSVVRGEQIQ   LKGTVYNYRT   850
851   SGMQFCVKMS   AVEGICTSES   PVIDHQGTKS   SKCVRQKVEG   SSSHLVTFTV   900
901   LPLEIGLHNI   NFSLETWFGK   EILVKTLRVV   PEGVKRESYS   GVTLDPRGIY   950
951   GTISRRKEFP   YRIPLDLVPK   TEIKRILSVK   GLLVGEILSA   VLSQEGINIL   1000
1001   THLPKGSAEA   ELMSVVPVFY   VFHYLETGNH   WNIFHSDPLI   EKQKLKKKLK   1050
1051   EGMLSIMSYR   NADYSYSVWK   GGSASTWLTA   FALRVLGQVN   KYVEQNQNSI   1100
1101   CNSLLWLVEN   YQLDNGSFKE   NSQYQPIKLQ   GTLPVEAREN   SLYLTAFTVI   1150
1151   GIRKAFDICP   LVKIDTALIK   ADNFLLENTL   PAQSTFTLAI   SAYALSLGDK   1200
1201   THPQFRSIVS   ALKREALVKG   NPPIYRFWKD   NLQHKDSSVP   NTGTARMVET   1250
1251   TAYALLTSLN   LKDINYVNPV   IKWLSEEQRY   GGGFYSTQDT   INAIEGLTEY   1300
1301   SLLVKQLRLS   MDIDVSYKHK   GALHNYKMTD   KNFLGRPVEV   LLNDDLIVST   1350
1351   GFGSGLATVH   VTTVVHKTST   SEEVCSFYLK   IDTQDIEASH   YRGYGNSDYK   1400
1401   RIVACASYKP   SREESSSGSS   HAVMDISLPT   GISANEEDLK   ALVEGVDQLF   1450
1451   TDYQIKDGHV   ILQLNSIPSS   DFLCVRFRIF   ELFEVGFLSP   ATFTVYEYHR   1500
1501   PDKQCTMFYS   TSNIKIQKVC   EGAACKCVEA   DCGQMQEELD   LTISAETRKQ   1550
1551   TACKPEIAYA   YKVSITSITV   ENVFVKYKAT   LLDIYKTGEA   VAEKDSEITF   1600
1601   IKKVTCTNAE   LVKGRQYLIM   GKEALQIKYN   FSFRYIYPLD   SLTWIEYWPR   1650
1651   DTTCSSCQAF   LANLDEFAED   IFLNGC       1700

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
49_ALA VAL 8.3kJPN
chr9:123808581 		-
- 0.0001 -
72_HIS ASN 8.3kJPN
chr9:123808513 		rs1239344218
- 0.0007 -
76_GLU ASP 8.3kJPN
chr9:123808499 		-
- 0.0001 -
108_SER TER 8.3kJPN
chr9:123805380 		-
- 0.0001 -
110_HIS ASN gnomAD
chr9:123805375 		rs143947726
- 0.000358594 -
145_VAL ILE VAR_038735 rs17216529
LB/B - -
145_VAL ILE gnomAD
chr9:123800218 		rs17216529
- 0.0779188 -
145_VAL ILE 8.3kJPN
chr9:123800218 		rs17216529
- 0.2014 -
164_ILE LYS 8.3kJPN
chr9:123800160 		-
- 0.0001 -
171_VAL ALA 8.3kJPN
chr9:123797153 		rs185695138
- 0.0013 -
176_GLU TER ClinVar
chr9:123797139 		-
Pathogenic - not provided [MedGen:C3661900]
238_ILE THR 8.3kJPN
chr9:123792720 		rs567288479
- 0.0001 -
238_ILE VAL 8.3kJPN
chr9:123792721 		-
- 0.0001 -
239_GLY SER gnomAD
chr9:123792718 		rs369524514
- 0.000692156 -
252_ALA THR gnomAD
chr9:123792679 		rs112959008
- 0.000320111 -
265_VAL ILE 8.3kJPN
chr9:123789518 		rs148539497
- 0.0001 -
274_ASP GLY 8.3kJPN
chr9:123789490 		-
- 0.0002 -
277_ASP GLY 8.3kJPN
chr9:123789481 		rs1462885944
- 0.0001 -
280_LYS ASN 8.3kJPN
chr9:123789471 		-
- 0.0012 -
281_GLU ASP 8.3kJPN
chr9:123789468 		rs201821112
- 0.0001 -
294_ASN LYS gnomAD
chr9:123787850 		rs774028867
- 0.00015167 -
297_ALA VAL 8.3kJPN
chr9:123787842 		rs1269751460
- 0.0001 -
298_GLN GLU gnomAD
chr9:123787840 		rs149346283
- 0.000111674 -
330_ILE THR gnomAD
chr9:123787743 		rs147430470
- 0.000620093 -
339_GLU GLY 8.3kJPN
chr9:123785782 		-
- 0.0005 -
354_LEU MET VAR_048822 rs34552775
LB/B - -
354_LEU MET gnomAD
chr9:123785738 		rs34552775
- 0.00529656 -
372_LYS ARG ClinVar
chr9:123785683 		rs587776846
Pathogenic - Complement component 5 deficiency [MONDO:MONDO:0012295,MedGen:C0343047,OMIM:609536]
389_THR ILE VAR_023946 -
LB/B - -
390_LEU VAL 8.3kJPN
chr9:123783921 		rs763556527
- 0.0001 -
405_ASP HIS 8.3kJPN
chr9:123783876 		-
- 0.0002 -
417_VAL ALA 8.3kJPN
chr9:123783839 		-
- 0.0001 -
429_THR LYS gnomAD
chr9:123783803 		rs145461325
- 0.000338061 -
429_THR MET 8.3kJPN
chr9:123783803 		rs145461325
- 0.0001 -
449_ARG GLY VAR_038736 rs2230213
LB/B - -
449_ARG GLY gnomAD
chr9:123782415 		rs2230213
- 0.0073537 -
451_GLY VAL 8.3kJPN
chr9:123782408 		rs56188613
- 0.0089 -
469_TRP TER ClinVar
chr9:123782353 		rs1408798589
Pathogenic/Likely pathogenic - not provided|Eculizumab, poor response to [MedGen:C3661900|MedGen:C3810402,OMIM:615749]; Complement component 5 deficiency [MONDO:MONDO:0012295,MedGen:C0343047,OMIM:609536]
473_HIS ARG gnomAD
chr9:123782342 		rs78640581
- 0.000230679 -
475_ALA VAL gnomAD
chr9:123782336 		rs151271738
- 0.000163072 -
493_ILE MET 8.3kJPN
chr9:123782281 		-
- 0.0001 -
506_LYS GLN 8.3kJPN
chr9:123780121 		-
- 0.0001 -
512_PHE LEU 8.3kJPN
chr9:123780103 		-
- 0.0001 -
514_THR MET 8.3kJPN
chr9:123780096 		rs199664327
- 0.003 -
515_ARG LYS 8.3kJPN
chr9:123780093 		rs1423414968
- 0.0001 -
518_PHE SER VAR_001996 -
LB/B - -
560_TRP TER ClinVar
chr9:123779957 		-
Pathogenic - not provided [MedGen:C3661900]
571_LEU VAL gnomAD
chr9:123779926 		rs147226792
- 0.000223104 -
572_GLN ARG 8.3kJPN
chr9:123779922 		-
- 0.0001 -
599_TRP TER 8.3kJPN
chr9:123779709 		-
- 0.0001 -
600_VAL GLU 8.3kJPN
chr9:123779707 		-
- 0.0001 -
605_VAL LEU 8.3kJPN
chr9:123779693 		-
- 0.0001 -
606_ASP ASN gnomAD
chr9:123779690 		rs775286780
- 0.000214925 -
647_HIS GLN gnomAD
chr9:123778587 		rs202080772
- 0.000178981 -
647_HIS GLN 8.3kJPN
chr9:123778587 		rs202080772
- 0.0004 -
673_LEU ILE gnomAD
chr9:123777519 		rs369245774
- 0.000184003 -
701_ASP ASN 8.3kJPN
chr9:123776307 		rs187925604
- 0.0001 -
714_ARG TER 8.3kJPN
chr9:123776268 		-
- 0.0001 -
734_VAL ILE 8.3kJPN
chr9:123776208 		rs771791383
- 0.0005 -
756_THR ILE 8.3kJPN
chr9:123770767 		rs1456300999
- 0.0003 -
802_VAL ILE VAR_014574 rs17611
LB/B - -
802_VAL ILE gnomAD
chr9:123769200 		rs17611
- 0.471368 -
802_VAL ILE 8.3kJPN
chr9:123769200 		rs17611
- 0.5195 -
809_ILE VAL 8.3kJPN
chr9:123768334 		rs750127089
- 0.0001 -
885_ARG CYS VAR_071067 rs373359894
LB/B - -
885_ARG HIS VAR_071068 rs56040400
LB/B - -
885_ARG HIS gnomAD
chr9:123759961 		rs56040400
- 0.00032607 -
885_ARG HIS 8.3kJPN
chr9:123759961 		rs56040400
- 0.019 -
907_LEU PHE 8.3kJPN
chr9:123759896 		rs772788429
- 0.0009 -
928_ARG GLN VAR_038737 rs41309892
LB/B - -
928_ARG TER ClinVar
chr9:123759833 		-
Pathogenic - not provided [MedGen:C3661900]
928_ARG GLN gnomAD
chr9:123759832 		rs41309892
- 0.0022379 -
933_GLY VAL VAR_038738 rs41309902
LB/B - -
965_LEU TER ClinVar
chr9:123753516 		-
Pathogenic - not provided [MedGen:C3661900]
966_ASP TYR VAR_048823 rs2230212
LB/B - -
966_ASP TYR gnomAD
chr9:123753514 		rs2230212
- 0.00474118 -
966_ASP TYR 8.3kJPN
chr9:123753514 		rs2230212
- 0.0317 -
1006_GLY ALA 8.3kJPN
chr9:123751983 		rs754352144
- 0.0005 -
1010_ALA VAL gnomAD
chr9:123751971 		rs34362143
- 0.000703928 -
1011_GLU ASP gnomAD
chr9:123751967 		rs150096192
- 0.000906719 -
1015_VAL ILE 8.3kJPN
chr9:123751957 		rs765069093
- 0.0001 -
1033_ILE THR VAR_038739 rs41311881
LB/B - -
1033_ILE THR gnomAD
chr9:123751902 		rs41311881
- 0.00120578 -
1037_ASP ASN VAR_038740 rs41311883
LB/B - -
1043_GLN LYS VAR_038741 rs41311887
LB/B - -
1043_GLN LYS gnomAD
chr9:123751873 		rs41311887
- 0.00493069 -
1053_MET LEU VAR_014575 rs17609
LB/B - -
1119_LYS ARG gnomAD
chr9:123744967 		rs142341763
- 0.000211822 -
1138_ARG GLN gnomAD
chr9:123744195 		rs779879112
- 0.000210836 -
1155_ALA THR gnomAD
chr9:123744145 		rs200624729
- 0.000282457 -
1183_GLN ARG 8.3kJPN
chr9:123742471 		-
- 0.0001 -
1214_ARG LYS gnomAD
chr9:123742378 		rs150470491
- 0.000262448 -
1257_THR SER gnomAD
chr9:123739072 		rs141704823
- 0.000512996 -
1291_ILE VAL gnomAD
chr9:123737203 		rs200674959
- 0.00025848 -
1310_SER ASN VAR_014576 rs17610
LB/B - -
1310_SER ASN gnomAD
chr9:123737145 		rs17610
- 0.00727767 -
1314_ASP ASN gnomAD
chr9:123737134 		rs771283592
- 0.000119307 -
1320_LYS GLN 8.3kJPN
chr9:123737116 		-
- - -
1325_ASN SER 8.3kJPN
chr9:123737100 		-
- 0.0001 -
1336_ARG LYS 8.3kJPN
chr9:123737067 		-
- 0.0002 -
1365_VAL ALA VAR_048824 rs16910245
LB/B - -
1402_ILE VAL gnomAD
chr9:123731355 		rs142459293
- 0.000469442 -
1405_CYS ARG 8.3kJPN
chr9:123731346 		rs753067140
- 0.0001 -
1437_GLU ASP VAR_014577 rs17612
LB/B - -
1437_GLU ASP gnomAD
chr9:123725926 		rs17612
- 0.0536851 -
1437_GLU ASP 8.3kJPN
chr9:123725926 		rs17612
- 0.0003 -
1454_GLN ARG 8.3kJPN
chr9:123725208 		-
- 0.0001 -
1476_ARG TER ClinVar
chr9:123725027 		rs121909588
Pathogenic - Complement component 5 deficiency|not provided|Eculizumab, poor response to [MONDO:MONDO:0012295,MedGen:C0343047,OMIM:609536|MedGen:C3661900|MedGen:C3810402,OMIM:615749]; Complement component 5 deficiency [MONDO:MONDO:0012295,MedGen:C0343047,OMIM:609536]
1478_ARG TRP gnomAD
chr9:123725021 		rs138933092
- 0.000143262 -
1478_ARG TRP 8.3kJPN
chr9:123725021 		rs138933092
- 0.0005 -
1499_HIS GLN 8.3kJPN
chr9:123724956 		-
- 0.0001 -
1538_GLU TER 8.3kJPN
chr9:123722592 		-
- 0.0001 -
1540_ASP ASN 8.3kJPN
chr9:123722586 		rs755260495
- 0.0004 -
1556_GLU GLY gnomAD
chr9:123722537 		rs201704886
- 0.000211261 -
1610_GLU GLY 8.3kJPN
chr9:123716080 		-
- 0.0001 -
1654_CYS ARG 8.3kJPN
chr9:123715088 		rs748755309
- 0.0001 -
1662_ALA VAL 8.3kJPN
chr9:123715063 		-
- 0.0001 -
1670_ASP HIS 8.3kJPN
chr9:123715040 		rs761048515
- 0.0006 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.