PDB ID 3SDL     CHAIN D
Protein name Ubiquitin-like protein ISG15
Uniprot Accession P05161
The number of similar proteins 10
The number of binding states 5
The number of binding partners 3

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3SDL (CHAIN: D)
1 P03502   P03502  
2 Monomeric state
3 P0DTC1  
4 P03502  
5 Q6TQF5  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   SHHHHHHMGW   DLTVKMLAGN   EFQVSLSSSM   SVSELKAQIT   QKIGVHAFQQ   50
51   RLAVHPSGVA   LQDRVPLASQ   GLGPGSTVLL   VVDKCDEPLS   ILVRNNKGRS   100
101   STYEVRLTQT   VAHLKQQVSG   LEGVQDDLFW   LTFEGKPLED   QLPLGEYGLK   150
151   PLSTVFMNLR   LRGG         200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
6_THR MET gnomAD
chr1:949377 		rs199853706
- 0.000105816 -
6_THR MET 8.3kJPN
chr1:949377 		rs199853706
- 0.0002 -
21_SER ASN gnomAD
chr1:949422 		rs143888043
- 0.00131018 -
38_VAL MET 8.3kJPN
chr1:949472 		rs202075563
- 0.0008 -
44_ARG HIS gnomAD
chr1:949491 		rs148041041
- 0.000103794 -
48_HIS TYR gnomAD
chr1:949502 		rs150861311
- 0.000103852 -
49_PRO LEU 8.3kJPN
chr1:949506 		rs760355237
- 0.0002 -
51_GLY CYS gnomAD
chr1:949511 		rs139516378
- 0.000495516 -
51_GLY SER 8.3kJPN
chr1:949511 		rs139516378
- 0.0001 -
53_ALA VAL 8.3kJPN
chr1:949518 		rs146063673
- 0.0002 -
55_GLN TER ClinVar
chr1:949523 		rs786201005
Pathogenic - Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency [MONDO:MONDO:0014502,MedGen:C4015293,OMIM:616126,Orphanet:319563]
76_ASP ASN 8.3kJPN
chr1:949586 		-
- 0.0003 -
83_SER ASN VAR_016181 rs1921
LB/B - -
83_SER ASN gnomAD
chr1:949608 		rs1921
- 0.359335 -
83_SER ASN 8.3kJPN
chr1:949608 		rs1921
- 0.1808 -
92_ARG CYS 8.3kJPN
chr1:949634 		-
- 0.0001 -
97_GLU LYS 8.3kJPN
chr1:949649 		rs554446856
- 0.0001 -
99_ARG TRP 8.3kJPN
chr1:949655 		rs770462897
- 0.0001 -
127_GLU TER ClinVar
chr1:949739 		rs672601312
Likely pathogenic - Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency [MONDO:MONDO:0014502,MedGen:C4015293,OMIM:616126,Orphanet:319563]
127_GLU TER 8.3kJPN
chr1:949739 		rs672601312
- 0.0001 -
141_GLY SER gnomAD
chr1:949781 		rs138829117
- 0.000404502 -
141_GLY SER 8.3kJPN
chr1:949781 		rs138829117
- 0.0001 -
147_THR ILE 8.3kJPN
chr1:949800 		rs773590823
- 0.0001 -
148_VAL MET gnomAD
chr1:949802 		rs202194159
- 0.00013256 -
153_ARG CYS 8.3kJPN
chr1:949817 		rs1339706366
- 0.0002 -
153_ARG HIS 8.3kJPN
chr1:949818 		rs1557674450
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.