PDB ID 4DRX CHAIN B
Protein name Tubulin beta chain
Uniprot Accession D0VWY9
The number of similar proteins 242
The number of binding states 12
The number of binding partners 8
Coloring
Unicolor (beige)
The number of binding partners
Group

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partners
  8
  7
  6
  5
  4
  3
  2
  1
  0
Sequence information
1   MREIVHIQAG   QCGNQIGAKF   WEVISDEHGI   DPTGSYHGDS   DLQLERINVY   50
51   YNEATGNKYV   PRAILVDLEP   GTMDSVRSGP   FGQIFRPDNF   VFGQSGAGNN   100
101   WAKGHYTEGA   ELVDSVLDVV   RKESESCDCL   QGFQLTHSLG   GGTGSGMGTL   150
151   LISKIREEYP   DRIMNTFSVM   PSPKVSDTVV   EPYNATLSVH   QLVENTDETY   200
201   SIDNEALYDI   CFRTLKLTTP   TYGDLNHLVS   ATMSGVTTCL   RFPGQLNADL   250
251   RKLAVNMVPF   PRLHFFMPGF   APLTSRGSQQ   YRALTVPELT   QQMFDSKNMM   300
301   AACDPRHGRY   LTVAAIFRGR   MSMKEVDEQM   LNVQNKNSSY   FVEWIPNNVK   350
351   TAVCDIPPRG   LKMSATFIGN   STAIQELFKR   ISEQFTAMFR   RKAFLHWYTG   400
401   EGMDEMEFTE   AESNMNDLVS   EYQQYQDATA   D     450
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
2_ARG GLY ClinVar
chr19:6502220
rs587776983 Pathogenic Autosomal dominant torsion dystonia 4 [MedGen:C1851943,OMIM:128101,Orphanet:ORPHA98805]; Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
2_ARG GLN ClinVar
chr19:6502219
rs587777467 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]; not provided [MedGen:CN517202]
2_ARG LYS ClinVar
chr10:95174
rs869025273 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
2_ARG TRP ClinVar
chr19:6502220
rs587776983 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
11_GLN HIS ClinVar
chr6:3227745
rs1135401758 Likely pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]; not provided [MedGen:CN517202]
15_GLN LYS ClinVar
chr6:30688326
rs864321676 Pathogenic Michelin-tire baby [MedGen:C4551592,OMIM:156610,SNOMED CT:239142006]
19_LYS GLN ClinVar
chr6:3227723
rs1057517932 Likely pathogenic not provided [MedGen:CN517202]
48_ARG TRP ClinVar
chr16:89999057
rs1555625363 Likely pathogenic Cortical dysplasia, complex, with other brain malformations 1 [MedGen:C3808397,OMIM:614039]
64_ARG GLN ClinVar
chr16:89999894
rs864321714 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]
71_GLU GLN ClinVar
chr6:3226465
rs1554126964 Likely pathogenic not provided [MedGen:CN517202]
73_GLY ARG ClinVar
chr16:89999920
rs864321715 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]; not provided [MedGen:CN517202]
98_GLY ARG ClinVar
chr19:6496224
rs1131691696 Pathogenic/Likely pathogenic not provided [MedGen:CN517202]
100_GLY ARG ClinVar
chr6:3226031
rs797046075 Pathogenic/Likely pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]; not provided [MedGen:CN517202]
100_GLY ARG ClinVar
chr6:3155143
rs1064795334 Pathogenic not provided [MedGen:CN517202]
108_TYR TER ClinVar
chr20:57598800
- Pathogenic Congenital hypothyroidism [Human Phenotype Ontology:HP:0000851,MedGen:C0010308,Orphanet:ORPHA442,SNOMED CT:190268003]
110_GLU LYS ClinVar
chr6:30691161
rs1057518412 Likely pathogenic not provided [MedGen:CN517202]
119_LEU PRO ClinVar
chr6:3225973
rs397514569 Likely pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]; not provided [MedGen:CN517202]
134_GLY SER ClinVar
chr6:3155041
rs1064795249 Likely pathogenic not provided [MedGen:CN517202]
144_GLY SER ClinVar
chr16:90001283
rs1131691895 Likely pathogenic not provided [MedGen:CN517202]
158_ARG LEU ClinVar
chr19:6496043
rs587777429 Pathogenic Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
162_PRO LEU ClinVar
chr20:57598961
- Pathogenic Congenital hypothyroidism [Human Phenotype Ontology:HP:0000851,MedGen:C0010308,Orphanet:ORPHA442,SNOMED CT:190268003]
174_SER PRO ClinVar
chr6:3225809
rs137853194 Pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
174_SER LEU ClinVar
chr6:3225808
rs1554126925 Likely pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
177_VAL LEU ClinVar
chr16:90001382
rs1555625571 Pathogenic Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
178_SER LEU ClinVar
chr10:93805
rs869025609 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
180_THR ARG ClinVar
chr19:6495977
rs587777468 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
180_THR MET ClinVar
chr6:3154902
rs886039447 Pathogenic not provided [MedGen:CN517202]
180_THR MET ClinVar
chr19:6495977
rs587777468 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
180_THR SER ClinVar
chr6:30691372
rs1057520046 Likely pathogenic not provided [MedGen:CN517202]
180_THR MET ClinVar
chr6:3225790
rs1057520391 Pathogenic not provided [MedGen:CN517202]
181_VAL LEU ClinVar
chr19:6495975
rs1057517986 Pathogenic not provided [MedGen:CN517202]
184_PRO THR ClinVar
chr19:6495966
rs886041008 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
192_HIS TYR ClinVar
chr19:6495942
rs761635539 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
196_GLU LYS ClinVar
chr6:3154855
rs1554122959 Pathogenic not provided [MedGen:CN517202]
207_GLU LYS ClinVar
chr16:90001472
rs878853257 Pathogenic Cortical dysplasia, complex, with other brain malformations 1 [MedGen:C3808397,OMIM:614039]
207_GLU ALA ClinVar
chr16:90001473
rs1057518593 Likely pathogenic not provided [MedGen:CN517202]
218_LYS ARG ClinVar
chr6:30691486
rs1059145 Likely pathogenic not provided [MedGen:CN517202]
223_THR ILE ClinVar
chr6:30691501
rs878853162 Pathogenic Cortical dysplasia, complex, with other brain malformations 6 [MedGen:C4014283,OMIM:615771]
224_TYR PHE ClinVar
chr6:30691504
rs864321677 Pathogenic Michelin-tire baby [MedGen:C4551592,OMIM:156610,SNOMED CT:239142006]
230_LEU PRO ClinVar
chr6:3225640
rs137853195 Pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
230_LEU VAL ClinVar
chr6:30691521
rs1057524718 Likely pathogenic not provided [MedGen:CN517202]
231_VAL ALA ClinVar
chr10:93646
rs869025271 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
232_SER LEU ClinVar
chr16:90001548
rs886041459 Pathogenic not provided [MedGen:CN517202]
240_THR MET ClinVar
chr10:93619
rs1057520306 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
241_CYS PHE ClinVar
chr6:3225607
rs878853284 Pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
241_CYS PHE ClinVar
chr19:6495794
rs886041009 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
243_ARG HIS ClinVar
chr6:3225601
rs1064794314 Likely pathogenic not provided [MedGen:CN517202]
244_PHE LEU ClinVar
chr6:3154711
rs1554122948 Likely pathogenic not provided [MedGen:CN517202]
245_PRO LEU ClinVar
chr6:3154707
rs1554122947 Pathogenic not provided [MedGen:CN517202]
246_GLY VAL ClinVar
chr19:6495779
rs886041010 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
246_GLY ASP ClinVar
chr19:6495779
rs886041010 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
246_GLY SER ClinVar
chr19:6495780
rs886041007 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
246_GLY ALA ClinVar
chr6:3154704
rs1057521918 Likely pathogenic not provided [MedGen:CN517202]
249_ASN LYS ClinVar
chr6:3154694
rs886037663 Pathogenic Cortical dysplasia, complex, with other brain malformations 5 [MedGen:C3810407,OMIM:615763]
250_ALA VAL ClinVar
chr6:3225580
rs777598117 Likely pathogenic not provided [MedGen:CN517202]
251_ASP ASN ClinVar
chr19:6495765
rs483352809 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]; not provided [MedGen:CN517202]
257_VAL ILE ClinVar
chr19:6495747
rs767399782 Pathogenic/Likely pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]; not provided [MedGen:CN517202]
257_VAL ILE ClinVar
chr16:90001622
rs1057517908 Likely pathogenic not provided [MedGen:CN517202]
262_PHE SER ClinVar
chr20:57599261
rs1057517996 Likely pathogenic not provided [MedGen:CN517202]
264_ARG CYS ClinVar
chr16:90001643
rs267607162 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]; not provided [MedGen:CN517202]
264_ARG HIS ClinVar
chr16:90001644
rs864321716 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]; not provided [MedGen:CN517202]
264_ARG GLN ClinVar
chr10:93547
rs869025610 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
264_ARG HIS ClinVar
chr19:6495725
rs886039470 Pathogenic Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]; Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]; not provided [MedGen:CN517202]
267_PHE LEU ClinVar
chr6:3225530
rs137853196 Pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
273_ALA THR ClinVar
chr19:6495699
rs587777074 Pathogenic Autosomal dominant torsion dystonia 4 [MedGen:C1851943,OMIM:128101,Orphanet:ORPHA98805]
280_SER ARG ClinVar
chr16:90001693
rs1085308026 Likely pathogenic not provided [MedGen:CN517202]
284_ARG PRO ClinVar
chr19:6495665
rs756762431 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
284_ARG PRO ClinVar
chr16:90001704
rs1064795231 Likely pathogenic not provided [MedGen:CN517202]
290_GLU LYS ClinVar
chr16:90001721
rs1057521924 Pathogenic not provided [MedGen:CN517202]
293_GLN PRO ClinVar
chr6:3154563
rs863224939 Likely pathogenic Cortical dysplasia, complex, with other brain malformations 5 [MedGen:C3810407,OMIM:615763]
293_GLN LYS ClinVar
chr6:3225452
rs1554126886 Likely pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
294_GLN LYS ClinVar
chr19:6495636
rs886041011 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
301_MET VAL ClinVar
chr6:30691734
rs587777355 Pathogenic Cortical dysplasia, complex, with other brain malformations 6 [MedGen:C4014283,OMIM:615771]
302_MET ILE ClinVar
chr10:93432
rs869025612 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
302_MET ILE ClinVar
chr19:6495610
rs886041012 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
304_ALA THR ClinVar
chr16:90001763
rs267607163 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]; not provided [MedGen:CN517202]
304_ALA VAL ClinVar
chr16:90001764
rs878853258 Pathogenic Cortical dysplasia, complex, with other brain malformations 1 [MedGen:C3808397,OMIM:614039]
316_ALA VAL ClinVar
chr19:6495569
rs886041013 Pathogenic/Likely pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]; not provided [MedGen:CN517202]
320_ARG TRP ClinVar
chr20:57599434
rs121918555 Pathogenic MACROTHROMBOCYTOPENIA, AUTOSOMAL DOMINANT, TUBB1-RELATED [MedGen:C2751259,OMIM:613112]
324_SER PHE ClinVar
chr6:3225358
rs587784502 Likely pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
325_MET VAL ClinVar
chr16:90001826
rs878853256 Pathogenic Cortical dysplasia, complex, with other brain malformations 1 [MedGen:C3808397,OMIM:614039]
325_MET ARG ClinVar
chr19:6495542
rs886041014 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
330_GLU LYS ClinVar
chr16:90001841
rs1057518686 Likely pathogenic Cortical dysplasia, complex, with other brain malformations 1 [MedGen:C3808397,OMIM:614039]
347_ILE PHE ClinVar
chr6:3154402
rs797046074 Pathogenic/Likely pathogenic Cortical dysplasia, complex, with other brain malformations 5 [MedGen:C3810407,OMIM:615763]
354_ALA THR ClinVar
chr19:6495456
rs886041015 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
355_VAL ILE ClinVar
chr6:30691896
rs587777356 Pathogenic Cortical dysplasia, complex, with other brain malformations 6 [MedGen:C4014283,OMIM:615771]
356_CYS TYR ClinVar
chr19:6495449
rs886041016 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
356_CYS TRP ClinVar
chr19:6495448
rs748787734 Likely pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
371_LEU ILE ClinVar
chr16:90001940
rs1064794940 Likely pathogenic not provided [MedGen:CN517202]
373_MET THR ClinVar
chr10:93244
rs869025611 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
374_ALA ASP ClinVar
chr19:6495419
rs886041017 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
377_PHE LEU ClinVar
chr19:6495411
rs886041018 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
377_PHE ILE ClinVar
chr19:6495411
rs886041018 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
390_ARG LEU ClinVar
chr6:3225184
rs587784498 Likely pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
390_ARG CYS ClinVar
chr16:90001997
rs864321717 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]; not provided [MedGen:CN517202]
398_MET ILE ClinVar
chr19:6495346
rs797045074 Likely pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
398_MET VAL ClinVar
chr16:90002021
rs878853279 Pathogenic Cortical dysplasia, complex, with other brain malformations 1 [MedGen:C3808397,OMIM:614039]
398_MET ILE ClinVar
chr19:6495346
rs797045074 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
398_MET THR ClinVar
chr19:6495347
rs886041020 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
398_MET VAL ClinVar
chr19:6495348
rs886041019 Likely pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]; not provided [MedGen:CN517202]
401_ARG LEU ClinVar
chr16:90002031
rs886039497 Pathogenic not provided [MedGen:CN517202]
401_ARG HIS ClinVar
chr19:6495338
rs886041021 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
401_ARG HIS ClinVar
chr6:3154263
rs1057521250 Likely pathogenic not provided [MedGen:CN517202]
401_ARG LEU ClinVar
chr19:6495338
rs886041021 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]; not provided [MedGen:CN517202]
401_ARG HIS ClinVar
chr9:140137842
rs1554786803 Pathogenic LEBER CONGENITAL AMAUROSIS WITH EARLY-ONSET DEAFNESS [MedGen:C4693498,OMIM:617879]
401_ARG CYS ClinVar
chr9:140137841
rs1554786802 Pathogenic LEBER CONGENITAL AMAUROSIS WITH EARLY-ONSET DEAFNESS [MedGen:C4693498,OMIM:617879]
404_PHE CYS ClinVar
chr19:6495329
rs886041022 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
404_PHE SER ClinVar
chr18:12325969
rs1555669248 Pathogenic FACIAL PALSY, CONGENITAL, WITH PTOSIS AND VELOPHARYNGEAL DYSFUNCTION [MedGen:C4540277,OMIM:617732]
407_TRP ARG ClinVar
chr6:3225134
rs1057520787 Likely pathogenic not provided [MedGen:CN517202]
411_GLU LYS ClinVar
chr6:30692040
rs587777357 Pathogenic Cortical dysplasia, complex, with other brain malformations 6 [MedGen:C4014283,OMIM:615771]; Inborn genetic diseases [MeSH:D030342,MedGen:C0950123]
413_MET ILE ClinVar
chr16:90002068
rs1131691632 Likely pathogenic not provided [MedGen:CN517202]
420_GLU LYS ClinVar
chr16:90002087
rs267607165 Pathogenic Cortical dysplasia, complex, with other brain malformations 1 [MedGen:C3808397,OMIM:614039]; Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]
420_GLU LYS ClinVar
chr19:6495282
rs587777428 Pathogenic Leukodystrophy, hypomyelinating, 6 [MedGen:C2676244,OMIM:612438,Orphanet:ORPHA139441]
420_GLU ASP ClinVar
chr6:30692069
rs1085307486 Likely pathogenic not provided [MedGen:CN517202]
424_ASN HIS ClinVar
chr6:3154195
rs1057518044 Likely pathogenic not provided [MedGen:CN517202]
427_ASP HIS ClinVar
chr16:90002108
rs267607164 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]
427_ASP ASN ClinVar
chr16:90002108
rs267607164 Pathogenic Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement [MedGen:C2748801,OMIM:600638]
427_ASP ASN ClinVar
chr6:3225074
rs397514567 Pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]
427_ASP ASN ClinVar
chr10:93083
rs869025272 Pathogenic Oocyte maturation defect 2 [MedGen:C4225210,OMIM:616780]
431_GLU LYS ClinVar
chr6:3225062
rs398122369 Pathogenic Polymicrogyria, asymmetric [MedGen:C3552236,OMIM:610031]