PDB ID 4FOE CHAIN B
Protein name Hexokinase-1
Uniprot Accession P19367
The number of similar proteins 16
The number of binding states 2
The number of binding partners 1
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
4FOE (CHAIN: B)
1 P19367  
2 Monomeric state
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partners
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Sequence information
1   MIAAQLLAYY   FTELKDDQVK   KIDKYLYAMR   LSDETLIDIM   TRFRKEMKNG   50
51   LSRDFNPTAT   VKMLPTFVRS   IPDGSEKGDF   IALDLGGSSF   RILRVQVNHE   100
101   KNQNVHMESE   VYDTPENIVH   GSGSQLFDHV   AECLGDFMEK   RKIKDKKLPV   150
151   GFTFSFPCQQ   SKIDEAILIT   WTKRFKASGV   EGADVVKLLN   KAIKKRGDYD   200
201   ANIVAVVNDT   VGTMMTCGYD   DQHCEVGLII   GTGTNACYME   ELRHIDLVEG   250
251   DEGRMCINTE   WGAFGDDGSL   EDIRTEFDRE   IDRGSLNPGK   QLFEKMVSGM   300
301   YLGELVRLIL   VKMAKEGLLF   EGRITPELLT   RGKFNTSDVS   AIEKNKEGLH   350
351   NAKEILTRLG   VEPSDDDCVS   VQHVCTIVSF   RSANLVAATL   GAILNRLRDN   400
401   KGTPRLRTTV   GVDGSLYKTH   PQYSRRFHKT   LRRLVPDSDV   RFLLSESGSG   450
451   KGAAMVTAVA   YRLAEQHRQI   EETLAHFHLT   KDMLLEVKKR   MRAEMELGLR   500
501   KQTHNNAVVK   MLPSFVRRTP   DGTENGDFLA   LDLGGTNFRV   LLVKIRSGKK   550
551   RTVEMHNKIY   AIPIEIMQGT   GEELFDHIVS   CISDFLDYMG   IKGPRMPLGF   600
601   TFSFPCQQTS   LDAGILITWT   KGFKATDCVG   HDVVTLLRDA   IKRREEFDLD   650
651   VVAVVNDTVG   TMMTCAYEEP   TCEVGLIVGT   GSNACYMEEM   KNVEMVEGDQ   700
701   GQMCINMEWG   AFGDNGCLDD   IRTHYDRLVD   EYSLNAGKQR   YEKMISGMYL   750
751   GEIVRNILID   FTKKGFLFRG   QISETLKTRG   IFETKFLSQI   ESDRLALLQV   800
801   RAILQQLGLN   STCDDSILVK   TVCGVVSRRA   AQLCGAGMAA   VVDKIRENRG   850
851   LDRLNVTVGV   DGTLYKLHPH   FSRIMHQTVK   ELSPKCNVSF   LLSEDGSGKG   900
901   AALITAVGVR   LRTEASS         950
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
414_GLY GLU ClinVar
chr10:71139827
rs1064795154 Likely pathogenic not provided [MedGen:CN517202]
445_SER LEU ClinVar
chr10:71142311
rs1064794848 Likely pathogenic not provided [MedGen:CN517202]
457_THR MET ClinVar
chr10:71142347
rs1057517928 Likely pathogenic not provided [MedGen:CN517202]
529_LEU SER ClinVar
chr10:71144104
rs137853249 Pathogenic Hemolytic anemia due to hexokinase deficiency [MedGen:C3150343,OMIM:235700,SNOMED CT:191177007]
680_THR SER ClinVar
chr10:71151884
rs398122379 Pathogenic Hemolytic anemia due to hexokinase deficiency [MedGen:C3150343,OMIM:235700,SNOMED CT:191177007]
776_LEU MET VAR_023781 rs1054203 Polymorphism -
847_GLU LYS ClinVar
chr10:71158514
rs777849213 Pathogenic Retinitis pigmentosa 79 [MedGen:C4479526,OMIM:617460]