PDB ID | 5C0Z | CHAIN | A |
---|---|---|---|
Protein name | Cytochrome c, somatic | ||
Uniprot Accession | P62898 | ||
The number of similar proteins | 58 | ||
The number of binding states | 6 | ||
The number of binding partners | 5 |
Unicolor (beige)
The number of binding partners
Group
Binding state |
Binding partners |
---|---|
5C0Z (CHAIN: A) | |
1 | Monomeric state |
2 | 171177 |
3 | P00004 |
4 | P68530 |
5 | P00004 P00004 |
6 | 2072141 S49220 |
Only interaction residues |
|
||||||||||
|
Residue | AA | Source | dbSNP | Clinical Significance |
Allele Frequency (> 0.0001) |
Disease name | |
---|---|---|---|---|---|---|---|
26_HIS | TYR |
ClinVar chr7:25163660 |
rs1783403912
|
Pathogenic | - | Thrombocytopenia 4|not provided [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322|MedGen:C3661900] | |
26_HIS | ASP |
8.3kJPN chr7:25163660 |
-
|
- | 0.0001 | - | |
41_GLY | SER |
ClinVar chr7:25163615 |
rs121918552
|
Likely pathogenic | - | Thrombocytopenia 4|Thrombocytopenia [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322|Human Phenotype Ontology:HP:0001873,Human Phenotype Ontology:HP:0001906,Human Phenotype Ontology:HP:0004838,Human Phenotype Ontology:HP:0008175,Human Phenotype Ontology:HP:0008268,Human Phenotype Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034] | |
48_TYR | HIS |
ClinVar chr7:25163594 |
rs886037737
|
Pathogenic | - | Thrombocytopenia 4 [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322] | |
51_ALA | VAL |
ClinVar chr7:25163584 |
rs1783401850
|
Likely pathogenic | - | Abnormal bleeding [Human Phenotype Ontology:HP:0001892,Human Phenotype Ontology:HP:0004830,Human Phenotype Ontology:HP:0004834,Human Phenotype Ontology:HP:0004849,Human Phenotype Ontology:HP:0004862,Human Phenotype Ontology:HP:0004865,Human Phenotype Ontology:HP:0008183,MedGen:C1458140]; Thrombocytopenia [Human Phenotype Ontology:HP:0001873,Human Phenotype Ontology:HP:0001906,Human Phenotype Ontology:HP:0004838,Human Phenotype Ontology:HP:0008175,Human Phenotype Ontology:HP:0008268,Human Phenotype Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034] | |
84_GLY | VAL |
8.3kJPN chr7:25163384 |
-
|
- | 0.0001 | - | |
96_ALA | ASP |
ClinVar chr7:25163348 |
-
|
Likely pathogenic | - | Thrombocytopenia 4 [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322] | |
98_LEU | VAL |
ClinVar chr7:25163343 |
rs1583394629
|
Likely pathogenic | - | Thrombocytopenia [Human Phenotype Ontology:HP:0001873,Human Phenotype Ontology:HP:0001906,Human Phenotype Ontology:HP:0004838,Human Phenotype Ontology:HP:0008175,Human Phenotype Ontology:HP:0008268,Human Phenotype Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034] | |
98_LEU | PHE |
ClinVar chr7:25163343 |
-
|
Likely pathogenic | - | CYCS-related condition [-] |