PDB ID 5C0Z     CHAIN A
Protein name Cytochrome c, somatic
Uniprot Accession P62898
The number of similar proteins 58
The number of binding states 6
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
5C0Z (CHAIN: A)
1 Monomeric state
2 171177  
3 P00004  
4 P68530  
5 P00004   P00004  
6 2072141   S49220  

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Format:

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Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   MGDVEKGKKI   FVQKCAQCHT   VEKGGKHKTG   PNLHGLFGRK   TGQAAGFSYT   50
51   DANKNKGITW   GEDTLMEYLE   NPKKYIPGTK   MIFAGIKKKG   ERADLIAYLK   100
101   KATNE           150

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(> 0.0001)
Disease name
26_HIS TYR ClinVar
chr7:25163660
rs1783403912
Pathogenic - Thrombocytopenia 4|not provided [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322|MedGen:C3661900]
26_HIS ASP 8.3kJPN
chr7:25163660
-
- 0.0001 -
41_GLY SER ClinVar
chr7:25163615
rs121918552
Likely pathogenic - Thrombocytopenia 4|Thrombocytopenia [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322|Human Phenotype Ontology:HP:0001873,Human Phenotype Ontology:HP:0001906,Human Phenotype Ontology:HP:0004838,Human Phenotype Ontology:HP:0008175,Human Phenotype Ontology:HP:0008268,Human Phenotype Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034]
48_TYR HIS ClinVar
chr7:25163594
rs886037737
Pathogenic - Thrombocytopenia 4 [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322]
51_ALA VAL ClinVar
chr7:25163584
rs1783401850
Likely pathogenic - Abnormal bleeding [Human Phenotype Ontology:HP:0001892,Human Phenotype Ontology:HP:0004830,Human Phenotype Ontology:HP:0004834,Human Phenotype Ontology:HP:0004849,Human Phenotype Ontology:HP:0004862,Human Phenotype Ontology:HP:0004865,Human Phenotype Ontology:HP:0008183,MedGen:C1458140]; Thrombocytopenia [Human Phenotype Ontology:HP:0001873,Human Phenotype Ontology:HP:0001906,Human Phenotype Ontology:HP:0004838,Human Phenotype Ontology:HP:0008175,Human Phenotype Ontology:HP:0008268,Human Phenotype Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034]
84_GLY VAL 8.3kJPN
chr7:25163384
-
- 0.0001 -
96_ALA ASP ClinVar
chr7:25163348
-
Likely pathogenic - Thrombocytopenia 4 [MONDO:MONDO:0012775,MedGen:C2677608,OMIM:612004,Orphanet:268322]
98_LEU VAL ClinVar
chr7:25163343
rs1583394629
Likely pathogenic - Thrombocytopenia [Human Phenotype Ontology:HP:0001873,Human Phenotype Ontology:HP:0001906,Human Phenotype Ontology:HP:0004838,Human Phenotype Ontology:HP:0008175,Human Phenotype Ontology:HP:0008268,Human Phenotype Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034]
98_LEU PHE ClinVar
chr7:25163343
-
Likely pathogenic - CYCS-related condition [-]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.