PDB ID 5CC0 CHAIN A
Protein name AncSR2 DNA Binding Domain
PDB 5CC0
The number of similar proteins 53
The number of binding states 2
The number of binding partners 1
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
5CC0 (CHAIN: A)
1 Monomeric state
2 4OOR  
Downdload
 Format:  
Molecule viewer
#binding
partners
  1
  0
Sequence information
1   SNASPPQKVC   LICGDEASGC   HYGVLTCGSC   KVFFKRAVEG   QHNYLCAGRN   50
51   DCIIDKIRRK   NCPACRLRKC   LQAGMTLGAR   KSKKL     100
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
423_ILE THR ClinVar
chrX:66863166
rs886041050 Likely pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
424_CYS TYR ClinVar
chrX:66863169
rs1555982860 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
435_ALA PRO ClinVar
chrX:66863201
rs1057521121 Likely pathogenic not provided [MedGen:CN517202]
439_GLY ARG ClinVar
chrX:66863213
rs137852596 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
441_CYS PHE ClinVar
chrX:66863220
rs137852586 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
441_CYS TYR ClinVar
chrX:66863220
rs137852586 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
444_PHE TYR ClinVar
chrX:66863229
rs137852587 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
451_GLY ARG ClinVar
chr4:149181130
rs121912566 Pathogenic Pseudohypoaldosteronism type 1 autosomal dominant [MedGen:C1449842,OMIM:177735,Orphanet:ORPHA171871]
452_LYS TER ClinVar
chrX:66905854
rs137852566 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
458_ALA THR ClinVar
chrX:66905872
rs137852569 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]; Bulbo-spinal atrophy X-linked [MedGen:C1839259,OMIM:313200,Orphanet:ORPHA481]; Partial androgen insensitivity syndrome [MedGen:C0268301,OMIM:312300,Orphanet:ORPHA90797,SNOMED CT:58672003]
463_CYS TER ClinVar
chr4:149115976
rs121912564 Pathogenic Pseudohypoaldosteronism type 1 autosomal dominant [MedGen:C1449842,OMIM:177735,Orphanet:ORPHA171871]
463_CYS GLY ClinVar
chrX:66905887
rs878853033 Pathogenic not provided [MedGen:CN517202]
463_CYS TYR ClinVar
chrX:66905888
rs1555990470 Likely pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]; Bulbo-spinal atrophy X-linked [MedGen:C1839259,OMIM:313200,Orphanet:ORPHA481]
466_ASP HIS ClinVar
chrX:66905896
rs1266872442 Likely pathogenic not provided [MedGen:CN517202]
469_ARG GLN ClinVar
chrX:66905906
rs137852573 Likely pathogenic Partial androgen insensitivity syndrome [MedGen:C0268301,OMIM:312300,Orphanet:ORPHA90797,SNOMED CT:58672003]; not provided [MedGen:CN517202]
469_ARG TER ClinVar
chrX:66905905
rs886041128 Pathogenic not provided [MedGen:CN517202]
469_ARG TER ClinVar
chr4:149115960
rs1131691921 Likely pathogenic not provided [MedGen:CN517202]
470_ARG LYS ClinVar
chrX:66905909
rs137852576 Pathogenic Androgen insensitivity, partial, with breast cancer [MedGen:C4016581]
477_ARG HIS ClinVar
chr5:142689700
rs104893913 Pathogenic Glucocorticoid resistance, generalized [MedGen:C1841972,OMIM:615962,Orphanet:ORPHA786]
477_ARG HIS ClinVar
chrX:66905930
rs754201976 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]; not provided [MedGen:CN517202]
477_ARG CYS ClinVar
chrX:66905929
rs1555990485 Pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]
478_LEU PRO ClinVar
chrX:66905933
rs1555990488 Likely pathogenic Androgen resistance syndrome [MedGen:C0039585,OMIM:300068,Orphanet:ORPHA754,SNOMED CT:12313004]