PDB ID 5CC0     CHAIN A
Protein name AncSR2 DNA Binding Domain
PDB 5CC0
The number of similar proteins 60
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
5CC0 (CHAIN: A)
1 Monomeric state
2 4OOR  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   SNASPPQKVC   LICGDEASGC   HYGVLTCGSC   KVFFKRAVEG   QHNYLCAGRN   50
51   DCIIDKIRRK   NCPACRLRKC   LQAGMTLGAR   KSKKL     100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
418_SER TER ClinVar
chr4:149181228 		rs2149871784
Likely pathogenic - Autosomal dominant pseudohypoaldosteronism type 1 [MONDO:MONDO:0008329,MedGen:C1449842,OMIM:177735,Orphanet:171871,Orphanet:756]
420_THR SER gnomAD
chrX:66863156 		rs139756052
- 0.000131005 -
423_ILE THR ClinVar
chrX:66863166 		rs886041050
Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
424_CYS TYR ClinVar
chrX:66863169 		rs1555982860
Pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
430_GLY TRP ClinVar
chrX:66863186 		rs1555982864
Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]; Kennedy disease [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]
433_TYR CYS ClinVar
chrX:66863196 		rs1925886715
Pathogenic/Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]; Kennedy disease|Androgen resistance syndrome|AR-related condition [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481|MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429|]
435_ALA PRO ClinVar
chrX:66863201 		rs1057521121
Likely pathogenic - not provided [MedGen:CN517202]
439_GLY ARG ClinVar
chrX:66863213 		rs137852596
Pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
440_SER ARG ClinVar
chrX:66863218 		-
Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
441_CYS PHE ClinVar
chrX:66863220 		rs137852586
Pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
441_CYS TYR ClinVar
chrX:66863220 		rs137852586
Pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
442_LYS THR ClinVar
chrX:66863223 		rs2147436623
Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
442_LYS ASN ClinVar
chrX:66863224 		-
Likely pathogenic - Kennedy disease [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]; Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
444_PHE TYR ClinVar
chrX:66863229 		rs137852587
Pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
444_PHE LEU ClinVar
chrX:66863230 		-
Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
447_ARG TER ClinVar
chrX:66863237 		-
Pathogenic - Kennedy disease [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]; Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
451_GLY ARG ClinVar
chr4:149181130 		rs121912566
Pathogenic - Autosomal dominant pseudohypoaldosteronism type 1 [MONDO:MONDO:0008329,MedGen:C1449842,OMIM:177735,Orphanet:171871,Orphanet:756]
452_LYS TER ClinVar
chrX:66905854 		rs137852566
Pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
457_CYS TYR ClinVar
chrX:66905870 		-
Likely pathogenic - not provided [MedGen:CN517202]
458_ALA THR ClinVar
chrX:66905872 		rs137852569
Pathogenic - Partial androgen insensitivity syndrome|Androgen resistance syndrome [MONDO:MONDO:0010720,MedGen:C0268301,OMIM:312300,Orphanet:90797|MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]; Kennedy disease|not provided [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481|MedGen:C3661900]
459_SER GLY gnomAD
chrX:66905875 		rs142280455
- 0.000305926 -
463_CYS TER ClinVar
chr4:149115976 		rs121912564
Pathogenic - Autosomal dominant pseudohypoaldosteronism type 1 [MONDO:MONDO:0008329,MedGen:C1449842,OMIM:177735,Orphanet:171871,Orphanet:756]
463_CYS GLY ClinVar
chrX:66905887 		rs878853033
Pathogenic - not provided [MedGen:CN517202]
463_CYS TYR ClinVar
chrX:66905888 		rs1555990470
Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]; Kennedy disease [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]
466_ASP HIS ClinVar
chrX:66905896 		rs1266872442
Likely pathogenic - not provided [MedGen:CN517202]
469_ARG GLN ClinVar
chrX:66905906 		rs137852573
Pathogenic/Likely pathogenic - Partial androgen insensitivity syndrome|not provided|Androgen resistance syndrome [MONDO:MONDO:0010720,MedGen:C0268301,OMIM:312300,Orphanet:90797|MedGen:C3661900|MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]; Kennedy disease [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]
469_ARG TER ClinVar
chrX:66905905 		rs886041128
Pathogenic - not provided|Kennedy disease [MedGen:C3661900|MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]; Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
469_ARG TER ClinVar
chr4:149115960 		rs1131691921
Pathogenic/Likely pathogenic - not provided|Autosomal dominant pseudohypoaldosteronism type 1|Pseudohyperaldosteronism type 2 [MedGen:C3661900|MONDO:MONDO:0008329,MedGen:C1449842,OMIM:177735,Orphanet:171871,Orphanet:756|MONDO:MONDO:0011517,MedGen:C1854631,OMIM:605115,Orphanet:88660]; Autosomal dominant pseudohypoaldosteronism type 1|NR3C2-related condition [MONDO:MONDO:0008329,MedGen:C1449842,OMIM:177735,Orphanet:171871,Orphanet:756|]
470_ARG LYS ClinVar
chrX:66905909 		rs137852576
Pathogenic - Androgen insensitivity, partial, with breast cancer [MedGen:C4016581]
472_ASN LYS ClinVar
chrX:66905916 		rs2075964906
Pathogenic - not provided [MedGen:C3661900]
477_ARG HIS ClinVar
chrX:66905930 		rs754201976
Pathogenic - not provided|Kennedy disease [MedGen:C3661900|MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]; Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
477_ARG CYS ClinVar
chrX:66905929 		rs1555990485
Pathogenic/Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]
478_LEU PRO ClinVar
chrX:66905933 		rs1555990488
Likely pathogenic - Androgen resistance syndrome [MONDO:MONDO:0019154,MedGen:C0039585,OMIM:300068,Orphanet:754,Orphanet:99429]; Kennedy disease [MONDO:MONDO:0010735,MedGen:C1839259,OMIM:313200,Orphanet:481]
479_ARG TER ClinVar
chr5:142689695 		rs1658915833
Pathogenic - not provided [MedGen:C3661900]
479_ARG GLN 8.3kJPN
chr5:142689694 		rs1400646165
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.