PDB ID 5HXB CHAIN Z
Protein name Protein cereblon
Uniprot Accession Q96SW2
The number of similar proteins 10
The number of binding states 6
The number of binding partners 7
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
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partners
  6
  5
  4
  3
  2
  1
  0
Sequence information
1   GSMEAKKPNI   INFDTSLPTS   HTYLGADMEE   FHGRTLHDDD   SCQVIPVLPQ   50
51   VMMILIPGQT   LPLQLFHPQE   VSMVRNLIQK   DRTFAVLAYS   NVQEREAQFG   100
101   TTAEIYAYRE   EQDFGIEIVK   VKAIGRQRFK   VLELRTQSDG   IQQAKVQILP   150
151   ECVLPSTMSA   VQLESLNKCQ   IFPSKPVSRE   DQCSYKWWQK   YQKRKFHCAN   200
201   LTSWPRWLYS   LYDAETLMDR   IKKQLREWDE   NLKDDSLPSN   PIDFSYRVAA   250
251   CLPIDDVLRI   QLLKIGSAIQ   RLRCELDIMN   KCTSLCCKQC   QETEITTKNE   300
301   IFSLSLCGPM   AAYVNPHGYV   HETLTVYKAC   NLNLIGRPST   EHSWFPGYAW   350
351   TVAQCKICAS   HIGWKFTATK   KDMSPQKFWG   LTRSALLPTI   PDTEDEISPD   400
401   KVILCL           450
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
391_CYS ARG ClinVar
chr3:3192707
rs797045036 Likely pathogenic Mental retardation, autosomal recessive 2 [MedGen:C1843942,OMIM:607417]; not provided [MedGen:CN517202]
419_ARG TER ClinVar
chr3:3192623
rs121918368 Pathogenic Mental retardation, autosomal recessive 2 [MedGen:C1843942,OMIM:607417]