PDB ID 8KME CHAIN 2
Protein name THROMBIN
Uniprot Accession P00734
The number of similar proteins 391
The number of binding states 26
The number of binding partners 18
Coloring
Unicolor (beige)
The number of binding partners
Group

Downdload
 Format:  
Molecule viewer
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0
Sequence information
1   IVEGSDAEIG   MSPWQVMLFR   KSPQELLCGA   SLISDRWVLT   AAHCLLYPPW   50
51   DKNFTENDLL   VRIGKHSRTR   YERNIEKISM   LEKIYIHPRY   NWRENLDRDI   100
101   ALMKLKKPVA   FSDYIHPVCL   PDRETAASLL   QAGYKGRVTG   WGNLKETWTA   150
151   NVGKGQPSVL   QVVNLPIVER   PVCKDSTRIR   ITDNMFCAGY   KPDEGKRGDA   200
201   CEGDSGGPFV   MKSPFNNRWY   QMGIVSWGEG   CDRDGKYGFY   THVFRLKKWI   250
251   QKVIDQFGE           300
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
32_MET THR ClinVar
chr11:46749554
rs121918481 Pathogenic Hereditary factor II deficiency disease [MedGen:C0272317,SNOMED CT:33297000]
37_PRO THR VAR_011782 rs5897 Polymorphism -
67_ARG CYS ClinVar
chr11:46749688
rs121918479 Pathogenic Hereditary factor II deficiency disease [MedGen:C0272317,SNOMED CT:33297000]
67_ARG HIS ClinVar
chr11:46749689
rs121918485 Pathogenic Hereditary factor II deficiency disease [MedGen:C0272317,SNOMED CT:33297000]
73_ARG HIS ClinVar
chr11:46749707
rs121918482 Pathogenic DYSPROTHROMBINEMIA PROTHROMBIN HIMI-II [na]
101_ARG TRP ClinVar
chr11:46750296
rs121918478 Pathogenic Hereditary factor II deficiency disease [MedGen:C0272317,SNOMED CT:33297000]
146_GLU ALA VAR_006718 - Disease Factor II deficiency (FA2D) [MIM:613679]
164_GLU GLN VAR_068913 - Polymorphism -
221_ASP GLU ClinVar
chr11:46760874
rs121918486 Pathogenic Hereditary factor II deficiency disease [MedGen:C0272317,SNOMED CT:33297000]
226_GLY VAL ClinVar
chr11:46760891
rs121918480 Pathogenic Hereditary factor II deficiency disease [MedGen:C0272317,SNOMED CT:33297000]