| PDB ID | 1A31
|
CHAIN | A |
|---|---|---|---|
| Protein name | PROTEIN (TOPOISOMERASE I) | ||
| Uniprot Accession | P11387 | ||
| The number of similar proteins | 15 | ||
| The number of binding states | 1 | ||
| The number of binding partners | 0 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1A31 (CHAIN: A) | |
| 1 | Monomeric state |
Downdload
Molecule viewer
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Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source | dbSNP | Clinical Significance |
Allele Frequency (> 0.0001) |
Disease name | |
|---|---|---|---|---|---|---|---|
| 291_LYS | THR |
8.3kJPN chr20:39726874 |
-
|
- | 0.0001 | - | |
| 296_ASN | SER |
gnomAD chr20:39726889 |
rs144769453
|
- | 0.000210873 | - | |
| 304_GLN | HIS |
8.3kJPN chr20:39726914 |
-
|
- | 0.0001 | - | |
| 326_LYS | ARG | VAR_036555 |
-
|
US | - | Breast cancer | |
| 335_LEU | VAL |
8.3kJPN chr20:39728723 |
-
|
- | 0.0001 | - | |
| 370_MET | THR | VAR_010666 |
-
|
US | - | CPT-resistant leukemia | |
| 376_ARG | GLN |
8.3kJPN chr20:39728847 |
-
|
- | 0.0001 | - | |
| 380_GLU | LYS |
8.3kJPN chr20:39728858 |
rs756669367
|
- | 0.0001 | - | |
| 418_GLU | LYS |
ClinVar chr20:39729937 |
rs121434562
|
Pathogenic | - | DNA topoisomerase I, camptothecin-resistant [MedGen:C4016020] | |
| 452_LYS | GLN |
8.3kJPN chr20:39741467 |
rs1265323416
|
- | 0.0001 | - | |
| 462_ARG | GLY |
8.3kJPN chr20:39741497 |
rs777034891
|
- | 0.0001 | - | |
| 469_GLU | LYS |
8.3kJPN chr20:39741518 |
-
|
- | 0.0001 | - | |
| 471_LYS | ARG |
8.3kJPN chr20:39741525 |
rs765735179
|
- | 0.0006 | - | |
| 533_ASP | GLY | VAR_007530 |
rs267607131
|
US | - | CPT-resistant leukemia | |
| 546_ARG | GLN |
8.3kJPN chr20:39742794 |
-
|
- | 0.0001 | - | |
| 596_ILE | VAL |
8.3kJPN chr20:39744996 |
-
|
- | 0.0001 | - | |
| 722_ASN | SER | VAR_010667 |
-
|
US | - | CPT-resistant leukemia | |
| 729_THR | ALA | VAR_007531 |
-
|
US | - | CPT-resistant lung cancer |