PDB ID 1A31 CHAIN A
Protein name PROTEIN (TOPOISOMERASE I)
Uniprot Accession P11387
The number of similar proteins 15
The number of binding states 1
The number of binding partners 0
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1A31 (CHAIN: A)
1 Monomeric state
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partners
  0
Sequence information
1   KPKNKDKDKK   VPEPDNKKKK   PKKEEEQKWK   WWEEERYPEG   IKWKFLEHKG   50
51   PVFAPPYEPL   PENVKFYYDG   KVMKLSPKAE   EVATFFAKML   DHEYTTKEIF   100
101   RKNFFKDWRK   EMTNEEKNII   TNLSKCDFTQ   MSQYFKAQTE   ARKQMSKEEK   150
151   LKIKEENEKL   LKEYGFCIMD   NHKERIANFK   IEPPGLFRGR   GNHPKMGMLK   200
201   RRIMPEDIII   NCSKDAKVPS   PPPGHKWKEV   RHDNKVTWLV   SWTENIQGSI   250
251   KYIMLNPSSR   IKGEKDWQKY   ETARRLKKCV   DKIRNQYRED   WKSKEMKVRQ   300
301   RAVALYFIDK   LALRAGNEKE   EGETADTVGC   CSLRVEHINL   HPELDGQEYV   350
351   VEFDFLGKDS   IRYYNKVPVE   KRVFKNLQLF   MENKQPEDDL   FDRLNTGILN   400
401   KHLQDLMEGL   TAKVFRTYNA   SITLQQQLKE   LTAPDENIPA   KILSYNRANR   450
451   AVAILCNHQR   APPKTFEKSM   MNLQTKIDAK   KEQLADARRD   LKSAKADAKV   500
501   MKDAKTKKVV   ESKKKAVQRL   EEQLMKLEVQ   ATDREENKQI   ALGTSKLNXL   550
551   DPRITVAWCK   KWGVPIEKIY   NKTQREKFAW   AIDMADEDYE   F   600
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
326_LYS ARG VAR_036555 - Unclassified Breast cancer
370_MET THR VAR_010666 - Unclassified CPT-resistant leukemia
418_GLU LYS ClinVar
chr20:39729937
rs121434562 Pathogenic DNA topoisomerase I, camptothecin-resistant [MedGen:C4016020]
533_ASP GLY VAR_007530 rs267607131 Unclassified CPT-resistant leukemia
722_ASN SER VAR_010667 - Unclassified CPT-resistant leukemia
729_THR ALA VAR_007531 - Unclassified CPT-resistant lung cancer