PDB ID 1A35 CHAINA
Protein namePROTEIN (DNA TOPOISOMERASE I)
Uniprot Accession P11387
The number of similar proteins 15
The number of binding states 1
The number of binding partners 0
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1A35 (CHAIN: A)
1 Monomeric state
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partners
  0
Sequence information
1  KPKNKDKDKK   VPEPDNKKKK   PKKEEEQKWK   WWEEERYPEG   IKWKFLEHKG   50
51  PVFAPPYEPL   PENVKFYYDG   KVMKLSPKAE   EVATFFAKML   DHEYTTKEIF   100
101  RKNFFKDWRK   EMTNEEKNII   TNLSKCDFTQ   MSQYFKAQTE   ARKQMSKEEK   150
151  LKIKEENEKL   LKEYGFCIMD   NHKERIANFK   IEPPGLFRGR   GNHPKMGMLK   200
201  RRIMPEDIII   NCSKDAKVPS   PPPGHKWKEV   RHDNKVTWLV   SWTENIQGSI   250
251  KYIMLNPSSR   IKGEKDWQKY   ETARRLKKCV   DKIRNQYRED   WKSKEMKVRQ   300
301  RAVALYFIDK   LALRAGNEKE   EGETADTVGC   CSLRVEHINL   HPELDGQEYV   350
351  VEFDFLGKDS   IRYYNKVPVE   KRVFKNLQLF   MENKQPEDDL   FDRLNTGILN   400
401  KHLQDLMEGL   TAKVFRTYNA   SITLQQQLKE   LTAPDENIPA   KILSYNRANR   450
451  AVAILCNHQR   APPKTFEKSM   MNLQTKIDAK   KEQLADARRD   LKSAKADAKV   500
501  MKDAKTKKVV   ESKKKAVQRL   EEQLMKLEVQ   ATDREENKQI   ALGTSKLNFL   550
551  DPRITVAWCK   KWGVPIEKIY   NKTQREKFAW   AIDMADEDYE   F          600
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
326_LYS ARG VAR_036555 - Unclassified Breast cancer
370_MET THR VAR_010666 - Unclassified CPT-resistant leukemia
533_ASP GLY VAR_007530 rs267607131 Unclassified CPT-resistant leukemia
722_ASN SER VAR_010667 - Unclassified CPT-resistant leukemia
729_THR ALA VAR_007531 - Unclassified CPT-resistant lung cancer