PDB ID 1B3U CHAIN A
Protein name PROTEIN (PROTEIN PHOSPHATASE PP2A)
Uniprot Accession P30153
The number of similar proteins 16
The number of binding states 7
The number of binding partners 6
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
1B3U (CHAIN: A)
1 Monomeric state
2 P67775  
3 Q9W9P1  
4 P67775   Q13362  
5 P67775   Q9Y5P8  
6 P67775   P63151  
7 P67775   Q8BH58  
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partners
  5
  4
  3
  2
  1
  0
Sequence information
1   AAADGDDSLY   PIAVLIDELR   NEDVQLRLNS   IKKLSTIALA   LGVERTRSEL   50
51   LPFLTDTIYD   EDEVLLALAE   QLGTFTTLVG   GPEYVHCLLP   PLESLATVEE   100
101   TVVRDKAVES   LRAISHEHSP   SDLEAHFVPL   VKRLAGGDWF   TSRTSACGLF   150
151   SVCYPRVSSA   VKAELRQYFR   NLCSDDTPMV   RRAAASKLGE   FAKVLELDNV   200
201   KSEIIPMFSN   LASDEQDSVR   LLAVEACVNI   AQLLPQEDLE   ALVMPTLRQA   250
251   AEDKSWRVRY   MVADKFTELQ   KAVGPEITKT   DLVPAFQNLM   KDCEAEVRAA   300
301   ASHKVKEFCE   NLSADCRENV   IMSQILPCIK   ELVSDANQHV   KSALASVIMG   350
351   LSPILGKDNT   IEHLLPLFLA   QLKDECPEVR   LNIISNLDCV   NEVIGIRQLS   400
401   QSLLPAIVEL   AEDAKWRVRL   AIIEYMPLLA   GQLGVEFFDE   KLNSLCMAWL   450
451   VDHVYAIREA   ATSNLKKLVE   KFGKEWAHAT   IIPKVLAMSG   DPNYLHRMTT   500
501   LFCINVLSEV   CGQDITTKHM   LPTVLRMAGD   PVANVRFNVA   KSLQKIGPIL   550
551   DNSTLQSEVK   PILEKLTQDQ   DVDVKYFAQE   ALTVLSLA     600
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
77_GLY ASP ClinVar
chr11:111635566
rs1805076 Pathogenic Lung cancer [MedGen:C0684249,OMIM:211980,SNOMED CT:187875007]
131_VAL LEU VAR_073718 - Disease Mental retardation, autosomal dominant 36 (MRD36) [MIM:616362]
178_PRO LEU ClinVar
chr19:52715971
rs786205228 Pathogenic Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Mental retardation, autosomal dominant 36 [MedGen:C4225352,OMIM:616362,Orphanet:ORPHA457284]; Uterine Carcinosarcoma [MedGen:C0280630]; not provided [MedGen:CN517202]
178_PRO ARG ClinVar
chr19:52715971
rs786205228 Likely pathogenic Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Uterine Carcinosarcoma [MedGen:C0280630]
181_ARG TRP ClinVar
chr19:52715979
rs786205227 Pathogenic Mental retardation, autosomal dominant 36 [MedGen:C4225352,OMIM:616362,Orphanet:ORPHA457284]; not provided [MedGen:CN517202]
182_ARG TRP ClinVar
chr19:52715982
rs1057519946 Likely pathogenic Adenocarcinoma of prostate [MedGen:C0007112]; Adenocarcinoma of stomach [MedGen:C0278701]; Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]; Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Neoplasm of the breast [Human Phenotype Ontology:HP:0100013,MeSH:D001943,MedGen:C1458155,Orphanet:ORPHA180250,SNOMED CT:126926005]; Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]; Ovarian Serous Cystadenocarcinoma [MedGen:C0279663]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]; Uterine Carcinosarcoma [MedGen:C0280630]
182_ARG GLN ClinVar
chr19:52715983
rs1057519947 Likely pathogenic Adenocarcinoma of prostate [MedGen:C0007112]; Adenocarcinoma of stomach [MedGen:C0278701]; Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]; Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Neoplasm of the breast [Human Phenotype Ontology:HP:0100013,MeSH:D001943,MedGen:C1458155,Orphanet:ORPHA180250,SNOMED CT:126926005]; Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]; Ovarian Serous Cystadenocarcinoma [MedGen:C0279663]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]; Uterine Carcinosarcoma [MedGen:C0280630]; not provided [MedGen:CN517202]
182_ARG GLY ClinVar
chr19:52715982
rs1057519946 Likely pathogenic Adenocarcinoma of prostate [MedGen:C0007112]; Adenocarcinoma of stomach [MedGen:C0278701]; Lung adenocarcinoma [Human Phenotype Ontology:HP:0030078,MeSH:C538231,MedGen:C0152013]; Malignant neoplasm of body of uterus [MedGen:C0153574,Orphanet:ORPHA213569]; Neoplasm of the breast [Human Phenotype Ontology:HP:0100013,MeSH:D001943,MedGen:C1458155,Orphanet:ORPHA180250,SNOMED CT:126926005]; Neoplasm of the large intestine [Human Phenotype Ontology:HP:0100834,MeSH:D015179,MedGen:C0009404,SNOMED CT:126837005]; Ovarian Serous Cystadenocarcinoma [MedGen:C0279663]; Squamous cell carcinoma of the head and neck [MeSH:C535575,MedGen:C1168401,OMIM:275355,Orphanet:ORPHA67037]; Uterine Carcinosarcoma [MedGen:C0280630]
257_ARG HIS ClinVar
chr19:52716329
rs863225094 Pathogenic Abnormal facial shape [Human Phenotype Ontology:HP:0001999,MedGen:C0424503]; Autistic behavior [Human Phenotype Ontology:HP:0000729,MedGen:C0856975]; Brachydactyly [Human Phenotype Ontology:HP:0001156,MedGen:C0221357,Orphanet:ORPHA294937,SNOMED CT:43476002]; Generalized hypotonia [Human Phenotype Ontology:HP:0001290,MedGen:C1858120]; Impaired use of nonverbal behaviors [Human Phenotype Ontology:HP:0000758,MedGen:C4021798]; Mental retardation, autosomal dominant 36 [MedGen:C4225352,OMIM:616362,Orphanet:ORPHA457284]; Microcephaly [Human Phenotype Ontology:HP:0000252,MedGen:C4551563]; Profound global developmental delay [Human Phenotype Ontology:HP:0012736,MedGen:C3553450]; Stereotypy [Human Phenotype Ontology:HP:0000733,MedGen:C0038273]; Synophrys [Human Phenotype Ontology:HP:0000664,MedGen:C0431447]; not provided [MedGen:CN517202]