PDB ID 1B41     CHAIN A
Protein name ACETYLCHOLINESTERASE
Uniprot Accession P22303
The number of similar proteins 99
The number of binding states 3
The number of binding partners 2

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1B41 (CHAIN: A)
1 P0C1Z0  
2 Monomeric state
3 P22303  

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Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   DAELLVTVRG   GRLRGIRLKT   PGGPVSAFLG   IPFAEPPMGP   RRFLPPEPKQ   50
51   PWSGVVDATT   FQSVCYQYVD   TLYPGFEGTE   MWNPNRELSE   DCLYLNVWTP   100
101   YPRPTSPTPV   LVWIYGGGFY   SGASSLDVYD   GRFLVQAERT   VLVSMNYRVG   150
151   AFGFLALPGS   REAPGNVGLL   DQRLALQWVQ   ENVAAFGGDP   TSVTLFGESA   200
201   GAASVGMHLL   SPPSRGLFHR   AVLQSGAPNG   PWATVGMGEA   RRRATQLAHL   250
251   VGCPPGGTGG   NDTELVACLR   TRPAQVLVNH   EWHVLPQESV   FRFSFVPVVD   300
301   GDFLSDTPEA   LINAGDFHGL   QVLVGVVKDE   GSYFLVYGAP   GFSKDNESLI   350
351   SRAEFLAGVR   VGVPQVSDLA   AEAVVLHYTD   WLHPEDPARL   REALSDVVGD   400
401   HNVVCPVAQL   AGRLAAQGAR   VYAYVFEHRA   STLSWPLWMG   VPHGYEIEFI   450
451   FGIPLDPSRN   YTAEEKIFAQ   RLMRYWANFA   RTGDPNEPRD   PKAPQWPPYT   500
501   AGAQQYVSLD   LRPLEVRRGL   RAQACAFWNR   FLPKLLSAT     550

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
11_THR MET gnomAD
chr7:100491729 		rs116298479
- 0.000181574 -
21_ARG SER gnomAD
chr7:100491700 		rs375017123
- 0.0001168 -
25_PRO LEU gnomAD
chr7:100491687 		rs114782198
- 0.000111773 -
25_PRO LEU 8.3kJPN
chr7:100491687 		rs114782198
- 0.0091 -
26_GLY ARG gnomAD
chr7:100491685 		rs17234982
- 0.00198851 -
51_GLU ALA 8.3kJPN
chr7:100491609 		rs1246706696
- 0.0001 -
58_GLY GLU gnomAD
chr7:100491588 		rs114367422
- 0.00193456 -
67_SER ASN 8.3kJPN
chr7:100491561 		rs760043016
- 0.0001 -
104_PRO ALA VAR_021326 rs17885778
LB/B - -
104_PRO ALA gnomAD
chr7:100491451 		rs17885778
- 0.00102671 -
107_ARG LEU gnomAD
chr7:100491441 		rs141299237
- 0.000447721 -
107_ARG LEU 8.3kJPN
chr7:100491441 		rs141299237
- 0.0004 -
116_VAL ILE 8.3kJPN
chr7:100491415 		rs146564868
- 0.0001 -
162_PRO LEU 8.3kJPN
chr7:100491276 		rs755147655
- 0.0001 -
216_PRO LEU gnomAD
chr7:100491114 		rs143875983
- 0.0010634 -
226_VAL MET 8.3kJPN
chr7:100491085 		rs745889870
- 0.0001 -
266_ASP VAL 8.3kJPN
chr7:100490964 		rs202174292
- 0.0001 -
291_GLN TER 8.3kJPN
chr7:100490890 		-
- 0.0001 -
302_VAL GLU VAR_011934 rs8286
LB/B - -
318_ALA VAL gnomAD
chr7:100490808 		rs750142131
- 0.000255793 -
318_ALA THR 8.3kJPN
chr7:100490809 		rs116131706
- 0.0001 -
322_HIS ASN VAR_002359 rs1799805
LB/B - -
322_HIS ASN gnomAD
chr7:100490797 		rs1799805
- 0.0398096 -
326_VAL ALA 8.3kJPN
chr7:100490438 		-
- 0.0001 -
355_SER ASN 8.3kJPN
chr7:100490351 		rs775874742
- 0.0007 -
429_VAL ILE gnomAD
chr7:100490130 		rs546907479
- 0.00012481 -
475_ARG GLN 8.3kJPN
chr7:100489991 		rs774422002
- 0.0009 -
504_THR MET 8.3kJPN
chr7:100488909 		rs1430893148
- 0.0001 -
509_GLN HIS 8.3kJPN
chr7:100488893 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.