PDB ID 1CJ0     CHAIN A
Protein name PROTEIN (SERINE HYDROXYMETHYLTRANSFERASE)
Uniprot Accession P07511
The number of similar proteins 20
The number of binding states 3
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1CJ0 (CHAIN: A)
1 P07511  
2 Monomeric state
3 p07511   p07511  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   WSSHEQMLAQ   PLKDSDAEVY   DIIKKESNRQ   RVGLELIASE   NFASRAVLEA   50
51   LGSCLNNKYS   EGYPGQRYYG   GTEHIDELET   LCQKRALQAY   GLDPQCWGVN   100
101   VQPYSGSPAN   FAVYTALVEP   HGRIMGLDLP   DGGHLTHGFM   TDKKKISATS   150
151   IFFESMAYKV   NPDTGYIDYD   RLEENARLFH   PKLIIAGTSC   YSRNLDYGRL   200
201   RKIADENGAY   LMADMAHISG   LVVAGVVPSP   FEHCHVVTTT   THKTLRGCRA   250
251   GMIFYRRGVR   SVDPKTGKEI   LYNLESLINS   AVFPGLQGGP   HNHAIAGVAV   300
301   ALKQAMTPEF   KEYQRQVVAN   CRALSAALVE   LGYKIVTGGS   DNHLILVDLR   350
351   SKGTDGGRAE   KVLEACSIAC   NKNTCPGDKS   ALRPSGLRLG   TPALTSRGLL   400
401   EKDFQKVAHF   IHRGIELTVQ   IQDDTGPRAT   LKEFKEKLAG   DEKHQRAVRA   450
451   LRQEVESFAA   LFPLPGLPGF         500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
24_ASN ASP 8.3kJPN
chr17:18257104 		rs201557147
- 0.0009 -
25_ARG GLN 8.3kJPN
chr17:18257100 		rs770150583
- 0.0001 -
82_ALA THR 8.3kJPN
chr17:18251699 		-
- 0.0001 -
94_GLN ARG 8.3kJPN
chr17:18251650 		rs759784953
- 0.0002 -
115_ARG HIS 8.3kJPN
chr17:18250919 		rs766011995
- 0.0001 -
123_ASP HIS 8.3kJPN
chr17:18250896 		rs768492092
- 0.0003 -
125_GLY ASP gnomAD
chr17:18250889 		rs563467894
- 0.00029054 -
134_ASP GLU gnomAD
chr17:18250861 		rs558723951
- 0.000151173 -
163_ARG CYS gnomAD
chr17:18244076 		rs148701087
- 0.00064225 -
169_LEU PRO gnomAD
chr17:18244057 		rs73291881
- 0.000100793 -
176_CYS SER 8.3kJPN
chr17:18243561 		-
- 0.0001 -
179_ARG TER 8.3kJPN
chr17:18243552 		rs748683840
- 0.0001 -
185_ARG TRP gnomAD
chr17:18243534 		rs115185998
- 0.000330246 -
188_LYS ARG gnomAD
chr17:18243524 		rs78909145
- 0.00607471 -
188_LYS ARG 8.3kJPN
chr17:18243524 		rs78909145
- 0.0001 -
198_MET LEU 8.3kJPN
chr17:18243495 		-
- 0.003 -
212_VAL MET gnomAD
chr17:18243453 		rs150889470
- 0.000111406 -
221_HIS ARG 8.3kJPN
chr17:18243425 		-
- 0.0001 -
268_ALA VAL 8.3kJPN
chr17:18238881 		rs1262762031
- 0.0001 -
300_GLU GLN gnomAD
chr17:18236516 		rs7215148
- 0.000701564 -
309_ILE THR 8.3kJPN
chr17:18236488 		rs758066653
- 0.0001 -
324_ARG HIS gnomAD
chr17:18233949 		rs141263245
- 0.000151121 -
324_ARG CYS 8.3kJPN
chr17:18233950 		rs758472877
- 0.001 -
355_SER ASN gnomAD
chr17:18232693 		rs139056136
- 0.000111838 -
409_VAL MET 8.3kJPN
chr17:18232135 		rs769762115
- 0.0001 -
412_ARG TRP 8.3kJPN
chr17:18232123 		rs551074461
- 0.0001 -
3742_GLU GLY 8.3kJPN
chr17:18232630 		-
- 0.0001 -
4041_ASP TYR gnomAD
chr17:18232153 		rs546838005
- 0.00022071 -
4041_ASP TYR 8.3kJPN
chr17:18232153 		rs546838005
- - -
4181_LEU PHE gnomAD
chr17:18232096 		rs1979277
- 0.268191 -
4181_LEU PHE 8.3kJPN
chr17:18232096 		rs1979277
- 0.0883 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.