PDB ID 1F0J     CHAIN A
Protein name PHOSPHODIESTERASE 4B
Uniprot Accession Q07343
The number of similar proteins 32
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1F0J (CHAIN: A)
1 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   SISRFGVNTE   NEDHLAKELE   DLNKWGLNIF   NVAGYSHNRP   LTCIMYAIFQ   50
51   ERDLLKTFRI   SSDTFITYMM   TLEDHYHSDV   AYHNSLHAAD   VAQSTHVLLS   100
101   TPALDAVFTD   LEILAAIFAA   AIHDVDHPGV   SNQFLINTNS   ELALMYNDES   150
151   VLENHHLAVG   FKLLQEEHCD   IFMNLTKKQR   QTLRKMVIDM   VLATDMSKHM   200
201   SLLADLKTMV   ETKKVTSSGV   LLLDNYTDRI   QVLRNMVHCA   DLSNPTKSLE   250
251   LYRQWTDRIM   EEFFQQGDKE   RERGMEISPM   CDKHTASVEK   SQVGFIDYIV   300
301   HPLWETWADL   VQPDAQDILD   TLEDNRNWYQ   SMIPQAPAPP   LDEQNRDCQG   350
351   LMEKFQFELT   LDEEDSEGPE   KEGEGHS       400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
155_ARG GLN 8.3kJPN
chr19:10568738 		rs1269711202
- 0.0002 -
159_LYS MET 8.3kJPN
chr19:10568750 		-
- 0.0001 -
161_ASP TYR 8.3kJPN
chr19:10568755 		-
- 0.0001 -
182_ASN SER 8.3kJPN
chr1:66828891 		-
- 0.0001 -
210_ARG CYS gnomAD
chr19:10570295 		rs201196140
- 0.000103517 -
220_MET ILE 8.3kJPN
chr19:10570327 		-
- 0.0001 -
225_ASP GLY 8.3kJPN
chr1:66829160 		-
- 0.0001 -
229_ALA THR 8.3kJPN
chr19:10570352 		rs183936414
- 0.0007 -
231_VAL MET 8.3kJPN
chr19:10570358 		-
- 0.0001 -
236_SER ARG gnomAD
chr1:66829194 		rs146166974
- 0.000195553 -
243_ALA VAL 8.3kJPN
chr1:66829214 		-
- 0.0001 -
291_SER PRO 8.3kJPN
chr5:58273170 		-
- 0.0001 -
313_LYS ARG gnomAD
chr19:10572271 		rs141379029
- 0.000369887 -
331_ARG TRP gnomAD
chr19:10572324 		rs146986676
- 0.00040994 -
341_MET LEU 8.3kJPN
chr19:10572354 		rs776679347
- 0.0002 -
359_THR PRO ClinVar
chr5:58272248 		rs397514467
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
367_THR PRO ClinVar
chr5:58272224 		rs2153305991
Likely pathogenic - not provided [MedGen:C3661900]
377_TYR CYS ClinVar
chr5:58272193 		rs1554033904
Likely pathogenic - not provided [MedGen:CN517202]
379_ASP ASN 8.3kJPN
chr1:66833737 		rs749156051
- 0.0001 -
385_ARG GLN gnomAD
chr19:10574476 		rs200669683
- 0.000234837 -
395_ASN THR 8.3kJPN
chr19:10574506 		rs758029716
- 0.0005 -
397_THR PRO 8.3kJPN
chr19:10574511 		rs1221315322
- 0.0011 -
408_ASP GLU gnomAD
chr1:66834547 		rs141437989
- 0.000422873 -
408_ASP GLU 8.3kJPN
chr1:66834547 		rs141437989
- 0.0001 -
409_ARG TRP 8.3kJPN
chr5:58271588 		rs775209507
- 0.0001 -
416_ARG CYS gnomAD
chr5:58271567 		rs371950648
- 0.000112275 -
422_ARG TRP 8.3kJPN
chr1:66834587 		rs201667673
- 0.0001 -
422_ARG HIS 8.3kJPN
chr19:10574587 		rs373223236
- 0.0002 -
423_GLU ALA ClinVar
chr5:58271545 		rs387906744
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
431_MET ILE 8.3kJPN
chr19:10574615 		rs1340115666
- 0.0001 -
437_ALA PRO 8.3kJPN
chr19:10574631 		-
- 0.0001 -
445_GLY ASP ClinVar
chr5:58270903 		rs397514469
Pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
450_ILE THR ClinVar
chr5:58270888 		rs587777188
Pathogenic - Acrodysostosis 2 with or without hormone resistance|not provided [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651|MedGen:C3661900]
456_GLU GLY ClinVar
chr5:58270870 		rs1743358464
Likely pathogenic - Acrodysostosis 2 with or without hormone resistance [MONDO:MONDO:0013822,MedGen:C3553250,OMIM:614613,Orphanet:280651]
462_VAL ILE 8.3kJPN
chr5:58270853 		rs192644692
- 0.0001 -
468_GLU LYS 8.3kJPN
chr19:10577635 		-
- 0.0001 -
472_THR SER 8.3kJPN
chr1:66838080 		rs779182342
- 0.0003 -
481_GLN HIS 8.3kJPN
chr5:58270794 		-
- 0.0001 -
485_ARG GLN gnomAD
chr19:10577687 		rs146370645
- 0.00111828 -
499_HIS ARG 8.3kJPN
chr19:10577735 		-
- 0.0001 -
507_GLN ARG 8.3kJPN
chr5:58270717 		-
- 0.0001 -
508_PHE LEU gnomAD
chr19:10577761 		rs200879302
- 0.000171326 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.