PiSITE

PDB ID	1FJ2	CHAIN	A
Protein name	PROTEIN (ACYL PROTEIN THIOESTERASE 1)
Uniprot Accession	O75608
The number of similar proteins	6
The number of binding states	1
The number of binding partners	0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1FJ2 (CHAIN: A)
1	Monomeric state

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Molecule viewer

Only interaction residues

#binding
partners

Sequence information

GAMDPEFMST

PLPAIVPAAR

KATAAVIFLH

GLGDTGHGWA

EAFAGIRSSH

IKYICPHAPV

RPVTLNMNVA

MPSWFDIIGL

SPDSQEDESG

IKQAAENIKA

100

101

LIDQEVKNGI

PSNRIILGGF

SQGGALSLYT

ALTTQQKLAG

VTALSCWLPL

150

151

RASFPQGPIG

GANRDISILQ

CHGDCDPLVP

LMFGSLTVEK

LKTLVNPANV

200

201

TFKTYEGMMH

SSCQQEMMDV

KQFIDKLLPP

250

Variants

Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
3_THR	ALA	gnomAD chr8:55014362	rs745915152	-	0.000103518	-
3_THR	ILE	8.3kJPN chr8:55014361	-	-	0.0001	-
10_PRO	LEU	8.3kJPN chr8:55014340	-	-	0.0001	-
44_ILE	THR	8.3kJPN chr8:54978329	rs1453836047	-	0.0001	-
88_ALA	VAL	gnomAD chr8:54974822	rs570488246	-	0.000118544	-
109_ILE	MET	gnomAD chr8:54967638	rs76859468	-	0.00347028	-
144_ARG	GLN	gnomAD chr8:54965231	rs79880432	-	0.000760011	-
144_ARG	TRP	gnomAD chr8:54965232	rs139689905	-	0.000179049	-
144_ARG	TRP	8.3kJPN chr8:54965232	rs139689905	-	0.0001	-
148_PRO	SER	VAR_060991	rs11549448	LB/B	-	-
148_PRO	SER	gnomAD chr8:54965220	rs11549448	-	0.00698939	-
153_GLY	SER	gnomAD chr8:54963739	rs147488464	-	0.000324233	-
159_ILE	THR	8.3kJPN chr8:54963720	rs1250604776	-	0.0007	-
180_THR	MET	8.3kJPN chr8:54963657	rs767257936	-	0.0001	-
190_PRO	ALA	gnomAD chr8:54963628	rs201245510	-	0.000147261	-
192_ASN	SER	8.3kJPN chr8:54963621	rs770312743	-	0.0001	-
205_SER	LEU	8.3kJPN chr8:54963582	rs371316608	-	0.0001	-
217_ILE	VAL	8.3kJPN chr8:54960654	-	-	0.0001	-
224_ILE	THR	8.3kJPN chr8:54960632	rs1333122163	-	0.0001	-

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