PDB ID 1K4Y     CHAIN A
Protein name LIVER CARBOXYLESTERASE
GenBank ID 3219695
The number of similar proteins 1
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1K4Y (CHAIN: A)
1 Monomeric state

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Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   PPVVDTVHGK   VLGKFVSLEG   FAQPVAVFLG   VPFAKPPLGS   LRFAPPQPAE   50
51   SWSHVKNTTS   YPPMCSQDAV   SGHMLSELFT   NRKENIPLKF   SEDCLYLNIY   100
101   TPADLTKRGR   LPVMVWIHGG   GLMVGGASTY   DGLALSAHEN   VVVVTIQYRL   150
151   GIWGFFSTGD   EHSRGNWGHL   DQVAALRWVQ   DNIANFGGDP   GSVTIFGESA   200
201   GGQSVSILLL   SPLTKNLFHR   AISESGVALL   SSLFRKNTKS   LAEKIAIEAG   250
251   CKTTTSAVMV   HCLRQKTEEE   LMEVTLKMKF   MALDLVGDPK   ENTAFLTTVI   300
301   DGVLLPKAPA   EILAEKKYNM   LPYMVGINQQ   EFGWIIPMQM   LGYPLSEGKL   350
351   DQKTATELLW   KSYPIVNVSK   ELTPVATEKY   LGGTDDPVKK   KDLFLDMLAD   400
401   LLFGVPSVNV   ARHHRDAGAP   TYMYEYRYRP   SFSSDMRPKT   VIGDHGDEIF   450
451   SVLGAPFLKE   GATEEEIKLS   KMVMKYWANF   ARNGNPNGEG   LPQWPAYDYK   500
501   EGYLQIGATT   QAAQKLKDKE   VAFWTELWAK   EAAR     550

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
32_LYS ASN 8.3kJPN
chr16:55862840 		-
- 0.0001 -
34_LEU ARG gnomAD
chr16:55862835 		rs749254726
- 0.000255814 -
38_VAL ILE 8.3kJPN
chr16:55862824 		rs3826192
- 0.1189 -
44_ALA VAL gnomAD
chr16:55862805 		rs142469038
- 0.000203111 -
48_ALA VAL 8.3kJPN
chr16:55862793 		-
- 0.0001 -
49_ILE VAL 8.3kJPN
chr16:55862791 		rs3826193
- 0.1027 -
68_PRO LEU gnomAD
chr16:55862733 		rs757329400
- 0.000123265 -
68_PRO SER 8.3kJPN
chr16:55862734 		rs1158400665
- 0.0001 -
75_SER ASN gnomAD
chr16:55862712 		rs2307240
- 0.0486827 -
75_SER ASN 8.3kJPN
chr16:55862712 		rs2307240
- 0.0425 -
78_LYS ARG 8.3kJPN
chr16:55862703 		rs373547343
- 0.0001 -
79_ASN ASP 8.3kJPN
chr16:55862701 		rs773058212
- 0.0007 -
82_SER LEU 8.3kJPN
chr16:55862691 		rs62028647
- 0.1819 -
86_MET VAL 8.3kJPN
chr16:55862680 		-
- 0.0001 -
93_ALA VAL gnomAD
chr16:55860187 		rs202111709
- 0.00011546 -
94_GLY VAL 8.3kJPN
chr16:55860184 		-
- 0.0001 -
101_PHE LEU 8.3kJPN
chr16:55860162 		rs750433997
- 0.0001 -
103_ASN ASP 8.3kJPN
chr16:55860158 		-
- 0.0003 -
124_PRO SER 8.3kJPN
chr16:55860095 		-
- 0.0001 -
141_GLY ARG 8.3kJPN
chr16:55857577 		rs778421449
- 0.0001 -
142_GLY GLU ClinVar
chr16:55857573 		rs121912777
Pathogenic - DRUG METABOLISM, ALTERED, CES1-RELATED [MedGen:C4748035,OMIM:618057]
142_GLY VAL 8.3kJPN
chr16:55857573 		rs121912777
- 0.0002 -
143_GLY GLU gnomAD
chr16:55857570 		rs71647871
- 0.010918 -
147_GLY CYS gnomAD
chr16:55857559 		rs146456965
- 0.000433817 -
148_ALA VAL gnomAD
chr16:55857555 		rs369026668
- 0.000111433 -
150_SER PRO 8.3kJPN
chr16:55857550 		-
- 0.0001 -
158_ALA VAL gnomAD
chr16:55857525 		rs202121317
- 0.00743687 -
158_ALA VAL 8.3kJPN
chr16:55857525 		rs202121317
- 0.0003 -
167_THR SER gnomAD
chr16:55857498 		rs147694791
- 0.00344171 -
167_THR SER 8.3kJPN
chr16:55857498 		rs147694791
- 0.0001 -
173_GLY ASP 8.3kJPN
chr16:55857480 		rs4784575
- 0.0622 -
174_ILE THR gnomAD
chr16:55857477 		rs751365501
- 0.000183397 -
176_GLY ARG 8.3kJPN
chr16:55857472 		-
- 0.0001 -
179_SER ASN 8.3kJPN
chr16:55857462 		-
- 0.0001 -
186_ARG PRO gnomAD
chr16:55855413 		rs60054861
- 0.0107501 -
186_ARG GLN gnomAD
chr16:55855413 		rs60054861
- 0.00190317 -
186_ARG PRO 8.3kJPN
chr16:55855413 		rs60054861
- 0.0002 -
186_ARG TRP 8.3kJPN
chr16:55855414 		rs200227274
- 0.0001 -
190_GLY CYS gnomAD
chr16:55855402 		rs150241462
- 0.000274605 -
197_ALA THR 8.3kJPN
chr16:55855381 		-
- 0.0001 -
199_ARG HIS gnomAD
chr16:55855374 		rs2307243
- 0.000688305 -
199_ARG HIS 8.3kJPN
chr16:55855374 		rs2307243
- 0.0001 -
203_ASP GLU gnomAD
chr16:55855361 		rs2307227
- 0.0326631 -
203_ASP GLU 8.3kJPN
chr16:55855361 		rs2307227
- 0.0101 -
212_PRO SER 8.3kJPN
chr16:55855336 		-
- 0.0001 -
220_GLU GLY gnomAD
chr16:55855311 		rs200707504
- 0.000361953 -
220_GLU GLY 8.3kJPN
chr16:55855311 		rs200707504
- 0.0091 -
242_ARG TRP 8.3kJPN
chr16:55854358 		rs376173751
- 0.0004 -
249_VAL MET 8.3kJPN
chr16:55854337 		rs778524104
- 0.0001 -
263_LEU PHE 8.3kJPN
chr16:55854290 		-
- 0.0001 -
268_ALA SER gnomAD
chr16:55853545 		rs115629050
- 0.0326835 -
268_ALA SER 8.3kJPN
chr16:55853545 		rs115629050
- 0.0104 -
271_ALA SER 8.3kJPN
chr16:55853536 		rs1567499789
- 0.0001 -
276_THR ALA 8.3kJPN
chr16:55853521 		rs200489319
- 0.0002 -
283_HIS GLN gnomAD
chr16:55853498 		rs114119971
- 0.00449884 -
286_ARG LEU gnomAD
chr16:55853490 		rs560426140
- 0.000131271 -
286_ARG TER 8.3kJPN
chr16:55853491 		rs144078935
- 0.0004 -
289_THR MET 8.3kJPN
chr16:55853481 		rs202001817
- 0.0007 -
296_THR MET 8.3kJPN
chr16:55853460 		rs767343447
- 0.0001 -
301_LYS GLU 8.3kJPN
chr16:55850874 		rs537106281
- 0.0033 -
308_GLN PRO 8.3kJPN
chr16:55850852 		-
- 0.0001 -
338_ARG GLY 8.3kJPN
chr16:55846883 		-
- 0.0001 -
339_ASN LYS gnomAD
chr16:55846878 		rs576295379
- 0.00075164 -
346_MET VAL gnomAD
chr16:55846859 		rs145135221
- 0.000258472 -
348_GLY ARG 8.3kJPN
chr16:55846853 		rs757978769
- 0.0001 -
376_THR SER gnomAD
chr16:55844877 		rs762507008
- 0.00011143 -
378_MET VAL gnomAD
chr16:55844871 		rs140704082
- 0.00103065 -
398_ALA THR 8.3kJPN
chr16:55844549 		-
- 0.0001 -
403_LEU PHE 8.3kJPN
chr16:55844532 		-
- 0.0001 -
404_GLY GLU 8.3kJPN
chr16:55844530 		-
- 0.0001 -
420_ILE ARG 8.3kJPN
chr16:55844482 		rs748876242
- 0.0001 -
431_ILE THR gnomAD
chr16:55844449 		rs114277361
- 0.000111361 -
432_VAL ALA 8.3kJPN
chr16:55844446 		-
- 0.0001 -
434_ARG GLY 8.3kJPN
chr16:55844441 		rs376976316
- 0.0004 -
437_ARG LYS 8.3kJPN
chr16:55844431 		-
- 0.0005 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.