PDB ID 1KV3     CHAIN A
Protein name Protein-glutamine gamma-glutamyltransferase
Uniprot Accession P21980
The number of similar proteins 10
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1KV3 (CHAIN: A)
1 P21980  
2 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MAEELVLERC   DLELETNGRD   HHTADLCREK   LVVRRGQPFW   LTLHFEGRNY   50
51   QASVDSLTFS   VVTGPAPSQE   AGTKARFPLR   DAVEEGDWTA   TVVDQQDCTL   100
101   SLQLTTPANA   PIGLYRLSLE   ASTGYQGSSF   VLGHFILLFN   AWCPADAVYL   150
151   DSEEERQEYV   LTQQGFIYQG   SAKFIKNIPW   NFGQFQDGIL   DICLILLDVN   200
201   PKFLKNAGRD   CSRRSSPVYV   GRVGSGMVNC   NDDQGVLLGR   WDNNYGDGVS   250
251   PMSWIGSVDI   LRRWKNHGCQ   RVKYGQCWVF   AAVACTVLRC   LGIPTRVVTN   300
301   YNSAHDQNSN   LLIEYFRNEF   GEIQGDKSEM   IWNFHCWVES   WMTRPDLQPG   350
351   YEGWQALDPT   PQEKSEGTYC   CGPVPVRAIK   EGDLSTKYDA   PFVFAEVNAD   400
401   VVDWIQQDDG   SVHKSINRSL   IVGLKISTKS   VGRDEREDIT   HTYKYPEGSS   450
451   EEREAFTRAN   HLNKLAEKEE   TGMAMRIRVG   QSMNMGSDFD   VFAHITNNTA   500
501   EEYVCRLLLC   ARTVSYNGIL   GPECGTKYLL   NLTLEPFSEK   SVPLCILYEK   550
551   YRDCLTESNL   IKVRALLVEP   VINSYLLAER   DLYLENPEIK   IRILGEPKQK   600
601   RKLVAEVSLQ   NPLPVALEGC   TFTVEGAGLT   EEQKTVEIPD   PVEAGEEVKV   650
651   RMDLVPLHMG   LHKLVVNFES   DKLKAVKGFR   NVIIGPA     700

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
16_THR ASN 8.3kJPN
chr20:36789965 		-
- 0.0001 -
23_THR MET 8.3kJPN
chr20:36789944 		rs147890243
- - -
23_THR ALA 8.3kJPN
chr20:36789945 		-
- 0.0001 -
28_ARG LEU gnomAD
chr20:36789929 		rs762006838
- 0.000127274 -
62_VAL MET gnomAD
chr20:36789828 		rs199577232
- 0.000103717 -
62_VAL MET 8.3kJPN
chr20:36789828 		rs199577232
- 0.0008 -
76_ARG HIS VAR_052553 rs41274720
LB/B - -
76_ARG HIS gnomAD
chr20:36784455 		rs41274720
- 0.00514476 -
76_ARG HIS 8.3kJPN
chr20:36784455 		rs41274720
- 0.0473 -
76_ARG CYS 8.3kJPN
chr20:36784456 		rs376510500
- 0.0001 -
101_SER LEU 8.3kJPN
chr20:36784380 		rs540320021
- 0.0001 -
110_ALA THR gnomAD
chr20:36784354 		rs146137365
- 0.000616703 -
116_ARG CYS gnomAD
chr20:36784336 		rs138618726
- 0.000262308 -
116_ARG CYS 8.3kJPN
chr20:36784336 		rs138618726
- 0.0006 -
209_ARG HIS gnomAD
chr20:36776418 		rs768583570
- 0.000145567 -
214_ARG HIS VAR_055357 rs45530133
LB/B - -
214_ARG HIS 8.3kJPN
chr20:36776403 		rs45530133
- 0.0026 -
222_ARG GLN gnomAD
chr20:36776379 		rs200551434
- 0.000318741 -
222_ARG GLN 8.3kJPN
chr20:36776379 		rs200551434
- 0.0001 -
262_ARG GLN 8.3kJPN
chr20:36775193 		rs768195948
- 0.0001 -
263_ARG HIS 8.3kJPN
chr20:36775190 		rs191236574
- 0.0001 -
263_ARG CYS 8.3kJPN
chr20:36775191 		rs746351550
- 0.0001 -
268_GLY SER 8.3kJPN
chr20:36775176 		rs778211918
- 0.0001 -
275_GLY SER 8.3kJPN
chr20:36775155 		-
- 0.0001 -
295_THR ALA gnomAD
chr20:36770578 		rs769750631
- 0.000186894 -
295_THR ALA 8.3kJPN
chr20:36770578 		rs769750631
- 0.0001 -
296_ARG HIS 8.3kJPN
chr20:36770574 		rs780860226
- 0.0002 -
306_ASP ASN 8.3kJPN
chr20:36770545 		-
- 0.0001 -
317_ARG LEU 8.3kJPN
chr20:36770511 		-
- 0.0001 -
318_ASN SER 8.3kJPN
chr20:36770508 		rs565017953
- 0.0001 -
324_GLN ARG VAR_055358 rs45567334
LB/B - -
330_MET ARG VAR_037998 rs141603506
US - -
330_MET THR gnomAD
chr20:36770472 		rs141603506
- 0.000206802 -
331_ILE ASN VAR_037999 -
US - -
345_PRO LEU 8.3kJPN
chr20:36769749 		rs374172551
- 0.0002 -
352_GLU LYS 8.3kJPN
chr20:36769729 		rs750818931
- 0.0001 -
366_GLU LYS gnomAD
chr20:36769687 		rs147979857
- 0.000370149 -
370_CYS TYR gnomAD
chr20:36768047 		rs769469786
- 0.000135574 -
377_ARG HIS gnomAD
chr20:36768026 		rs78619991
- 0.000549507 -
383_ASP ASN 8.3kJPN
chr20:36768009 		rs137876403
- 0.0006 -
390_ALA VAL 8.3kJPN
chr20:36767987 		rs781479212
- 0.0001 -
401_VAL GLU gnomAD
chr20:36767954 		rs201212727
- 0.000127242 -
422_VAL ALA 8.3kJPN
chr20:36767891 		-
- 0.0001 -
431_VAL LEU 8.3kJPN
chr20:36767865 		rs200013031
- 0.0007 -
433_ARG GLN gnomAD
chr20:36767858 		rs142184177
- 0.000966333 -
436_ARG TRP VAR_055359 rs45629036
LB/B - -
436_ARG TRP gnomAD
chr20:36767850 		rs45629036
- 0.000604494 -
436_ARG GLN 8.3kJPN
chr20:36767849 		rs780056790
- 0.0002 -
469_GLU GLY gnomAD
chr20:36766724 		rs139974885
- 0.000978162 -
469_GLU GLY 8.3kJPN
chr20:36766724 		rs139974885
- 0.0038 -
494_HIS LEU gnomAD
chr20:36766649 		rs151245834
- 0.000131835 -
536_PRO SER VAR_052554 rs45556333
LB/B - -
536_PRO SER gnomAD
chr20:36766524 		rs45556333
- 0.000502605 -
536_PRO SER 8.3kJPN
chr20:36766524 		rs45556333
- 0.0052 -
542_VAL PHE gnomAD
chr20:36760894 		rs2229473
- 0.00367837 -
542_VAL ILE gnomAD
chr20:36760894 		rs2229473
- 0.000123275 -
542_VAL PHE 8.3kJPN
chr20:36760894 		rs2229473
- 0.0114 -
548_TYR TER 8.3kJPN
chr20:36760874 		-
- 0.0008 -
570_PRO LEU 8.3kJPN
chr20:36760809 		rs149480979
- 0.0001 -
592_ARG TRP 8.3kJPN
chr20:36760744 		rs201666703
- 0.0008 -
612_PRO THR gnomAD
chr20:36759574 		rs199563008
- 0.000195274 -
628_GLY SER 8.3kJPN
chr20:36759526 		rs745849200
- 0.0001 -
636_VAL MET 8.3kJPN
chr20:36759502 		rs377170051
- 0.0002 -
638_ILE THR 8.3kJPN
chr20:36759495 		-
- 0.0001 -
642_VAL LEU gnomAD
chr20:36758761 		rs148951551
- 0.000138798 -
656_PRO LEU 8.3kJPN
chr20:36758718 		rs756435669
- 0.0001 -
660_GLY VAL VAR_036554 -
US - A colorectal cancer sample
669_GLU LYS gnomAD
chr20:36758680 		rs150186613
- 0.000194099 -
680_ARG TRP 8.3kJPN
chr20:36758647 		rs146621816
- 0.0001 -
684_ILE THR 8.3kJPN
chr20:36758634 		rs373901593
- 0.0006 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.