PDB ID 2A14     CHAIN A
Protein name indolethylamine N-methyltransferase
Uniprot Accession O95050
The number of similar proteins 1
The number of binding states 1
The number of binding partners 0

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2A14 (CHAIN: A)
1 Monomeric state

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  0

Sequence information

1   MKGGFTGGDE   YQKHFLPRDY   LATYYSFDGS   PSPEAEMLKF   NLECLHKTFG   50
51   PGGLQGDTLI   DIGSGPTIYQ   VLAACDSFQD   ITLSDFTDRN   REELEKWLKK   100
101   EPGAYDWTPA   VKFACELEGN   SGRWEEKEEK   LRAAVKRVLK   CDVHLGNPLA   150
151   PAVLPLADCV   LTLLAMECAC   CSLDAYRAAL   CNLASLLKPG   GHLVTTVTLR   200
201   LPSYMVGKRE   FSCVALEKGE   VEQAVLDAGF   DIEQLLHSPQ   SYSVTNAANN   250
251   GVCCIVARKK   PGP         300

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
15_PHE LEU 8.3kJPN
chr7:30791811 		-
- 0.0001 -
16_LEU MET 8.3kJPN
chr7:30791812 		-
- 0.0001 -
17_PRO THR 8.3kJPN
chr7:30791815 		-
- 0.0001 -
28_ASP ASN VAR_036991 rs4723010
LB/B - -
28_ASP ASN gnomAD
chr7:30791848 		rs4723010
- 0.328709 -
28_ASP ASN 8.3kJPN
chr7:30791848 		rs4723010
- 0.0089 -
36_GLU LYS gnomAD
chr7:30791872 		rs777797023
- 0.00010738 -
46_HIS PRO gnomAD
chr7:30791903 		rs77743549
- 0.00757799 -
46_HIS PRO 8.3kJPN
chr7:30791903 		rs77743549
- 0.0198 -
58_THR MET gnomAD
chr7:30793365 		rs149212813
- 0.00048514 -
58_THR MET 8.3kJPN
chr7:30793365 		rs149212813
- 0.0001 -
65_GLY VAL 8.3kJPN
chr7:30793386 		-
- 0.0001 -
77_SER PHE gnomAD
chr7:30793422 		rs749098351
- 0.000139168 -
91_ARG GLN gnomAD
chr7:30793464 		rs200629016
- 0.000290284 -
105_TYR HIS 8.3kJPN
chr7:30793505 		-
- 0.0001 -
110_ALA VAL gnomAD
chr7:30793521 		rs201737289
- 0.000135396 -
114_ALA THR gnomAD
chr7:30793532 		rs76338133
- 0.00305004 -
122_GLY SER 8.3kJPN
chr7:30795039 		rs773637647
- 0.0001 -
123_ARG GLN gnomAD
chr7:30795043 		rs771524226
- 0.000102556 -
123_ARG GLN 8.3kJPN
chr7:30795043 		rs771524226
- 0.0001 -
134_ALA VAL 8.3kJPN
chr7:30795076 		rs138101791
- 0.0002 -
138_VAL LEU gnomAD
chr7:30795087 		rs116374800
- 0.000420451 -
144_HIS ARG gnomAD
chr7:30795106 		rs145951192
- 0.000139669 -
148_PRO LEU 8.3kJPN
chr7:30795118 		rs1350170100
- 0.0003 -
151_PRO LEU 8.3kJPN
chr7:30795127 		rs774227443
- 0.0005 -
157_ALA THR gnomAD
chr7:30795144 		rs146202730
- 0.000148754 -
166_MET ILE 8.3kJPN
chr7:30795173 		rs746356539
- 0.0002 -
177_ARG CYS 8.3kJPN
chr7:30795204 		rs753027832
- 0.0005 -
177_ARG HIS 8.3kJPN
chr7:30795205 		rs996421042
- 0.0011 -
184_ALA SER 8.3kJPN
chr7:30795225 		-
- 0.0001 -
189_PRO LEU gnomAD
chr7:30795241 		rs142938904
- 0.000608476 -
202_PRO LEU gnomAD
chr7:30795280 		rs147878270
- 0.000334046 -
205_MET VAL VAR_011616 rs2302339
LB/B - -
205_MET VAL gnomAD
chr7:30795288 		rs2302339
- 0.292205 -
205_MET VAL 8.3kJPN
chr7:30795288 		rs2302339
- 0.1025 -
209_ARG HIS 8.3kJPN
chr7:30795301 		rs1473024059
- 0.0001 -
214_VAL MET VAR_061373 rs56800285
LB/B - -
214_VAL MET gnomAD
chr7:30795315 		rs56800285
- 0.000190881 -
217_GLU LYS 8.3kJPN
chr7:30795324 		-
- 0.0001 -
219_GLU GLY gnomAD
chr7:30795331 		rs2302340
- 0.416419 -
219_GLU GLY 8.3kJPN
chr7:30795331 		rs2302340
- 0.6194 -
246_ASN SER VAR_036992 rs6970210
LB/B - -
246_ASN SER gnomAD
chr7:30795412 		rs6970210
- 0.0100955 -
251_GLY GLU 8.3kJPN
chr7:30795427 		-
- 0.0001 -
254_PHE CYS gnomAD
chr7:30795436 		rs4720015
- 0.860493 -
254_PHE CYS 8.3kJPN
chr7:30795436 		rs4720015
- 0.8084 -
258_ARG HIS VAR_036994 rs6970605
LB/B - -
258_ARG GLY gnomAD
chr7:30795447 		rs150713465
- 0.000108104 -
258_ARG CYS gnomAD
chr7:30795447 		rs150713465
- 0.000224215 -
258_ARG HIS gnomAD
chr7:30795448 		rs6970605
- 0.0162382 -
261_PRO SER gnomAD
chr7:30795456 		rs76297889
- 0.0135765 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.