PDB ID 2A73 CHAIN B
Protein name Complement C3
Uniprot Accession P01024
The number of similar proteins 18
The number of binding states 9
The number of binding partners 10
Coloring
Unicolor (beige)
The number of binding partners
Group

Downdload
 Format:  
Molecule viewer
#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0
Sequence information
1   VQLTEKRMDK   VGKYPKELRK   CCEDGMRENP   MRFSCQRRTR   FISLGEACKK   50
51   VFLDCCNYIT   ELRRQHARAS   HLGLARSNLD   EDIIAEENIV   SRSEFPESWL   100
101   WNVEDLKEPP   KNGISTKLMN   IFLKDSITTW   EILAVSMSDK   KGICVADPFE   150
151   VTVMQDFFID   LRLPYSVVRN   EQVEIRAVLY   NYRQNQELKV   RVELLHNPAF   200
201   CSLATTKRRH   QQTVTIPPKS   SLSVPYVIVP   LKTGLQEVEV   KAAVYHHFIS   250
251   DGVRKSLKVV   PEGIRMNKTV   AVRTLDPERL   GREGVQKEDI   PPADLSDQVP   300
301   DTESETRILL   QGTPVAQMTE   DAVDAERLKH   LIVTPSGCGE   QNMIGMTPTV   350
351   IAVHYLDETE   QWEKFGLEKR   QGALELIKKG   YTQQLAFRQP   SSAFAAFVKR   400
401   APSTWLTAYV   VKVFSLAVNL   IAIDSQVLCG   AVKWLILEKQ   KPDGVFQEDA   450
451   PVIHQEMIGG   LRNNNEKDMA   LTAFVLISLQ   EAKDICEEQV   NSLPGSITKA   500
501   GDFLEANYMN   LQRSYTVAIA   GYALAQMGRL   KGPLLNKFLT   TAKDKNRWED   550
551   PGKQLYNVEA   TSYALLALLQ   LKDFDFVPPV   VRWLNEQRYY   GGGYGSTQAT   600
601   FMVFQALAQY   QKDAPDHQEL   NLDVSLQLPS   RSSKITHRIH   WESASLLRSE   650
651   ETKENEGFTV   TAEGKGQGTL   SVVTMYHAKA   KDQLTCNKFD   LKVTIKPAPE   700
701   TEKRPQDAKN   TMILEICTRY   RGDQDATMSI   LDISMMTGFA   PDTDDLKQLA   750
751   NGVDRYISKY   ELDKAFSDRN   TLIIYLDKVS   HSEDDCLAFK   VHQYFNVELI   800
801   QPGAVKVYAY   YNLEESCTRF   YHPEKEDGKL   NKLCRDELCR   CAEENCFIQK   850
851   SDDKVTLEER   LDKACEPGVD   YVYKTRLVKV   QLSNDFDEYI   MAIEQTIKSG   900
901   SDEVQVGQQR   TFISPIKCRE   ALKLEEKKHY   LMWGLSSDFW   GEKPNLSYII   950
951   GKDTWVEHWP   EEDECQDEEN   QKQCQDLGAF   TESMVVFGCP   N   1000
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
713_ARG TRP VAR_063215 rs117793540 Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
841_ARG LYS VAR_019206 rs11569472 Polymorphism -
1020_ARG LEU VAR_063655 - Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1072_ALA VAL VAR_063216 rs121909584 Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1093_ASP ASN VAR_063217 rs121909585 Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1136_CYS TRP VAR_063218 - Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1139_GLN LYS VAR_063219 - Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1202_GLY ASP VAR_019207 rs11569534 Polymorphism -
1281_ARG HIS ClinVar
chr19:6685060
rs775015499 Likely pathogenic Atypical hemolytic-uremic syndrome 5 [MedGen:C2752037,OMIM:612925,Orphanet:ORPHA93575]
1345_ILE THR VAR_019208 rs11569541 Polymorphism -
1442_HIS ASP VAR_063220 - Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
1499_GLN ARG VAR_029792 rs7256789 Polymorphism -
1579_HIS ASN VAR_029793 rs1803225 Polymorphism -
1597_SER ARG VAR_029326 rs2230210 Polymorphism -