PDB ID 2AVD     CHAIN A
Protein name Catechol-O-methyltransferase
Uniprot Accession Q86VU5
The number of similar proteins 2
The number of binding states 1
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2AVD (CHAIN: A)
1 Q86VU5  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   GSPPWRGRRE   QCLLPPEDSR   LWQYLLSRSM   REHPALRSLR   LLTLEQPQGD   50
51   SMMTCEQAQL   LANLARLIQA   KKALDLGTFT   GYSALALALA   LPADGRVVTC   100
101   EVDAQPPELG   RPLWRQAEAE   HKIDLRLKPA   LETLDELLAA   GEAGTFDVAV   150
151   VDADKENCSA   YYERCLQLLR   PGGILAVLRV   LWRGKVLQPP   KGDVAAECVR   200
201   NLNERIRRDV   RVYISLLPLG   DGLTLAFKI       250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
49_PRO ARG gnomAD
chr10:76995450 		rs534512374
- 0.000266297 -
50_GLU TER 8.3kJPN
chr10:76995448 		-
- 0.0001 -
52_SER GLY gnomAD
chr10:76995442 		rs200334065
- 0.00147422 -
63_MET VAL 8.3kJPN
chr10:76995409 		rs745586661
- 0.0001 -
64_ARG GLN gnomAD
chr10:76995405 		rs757609580
- 0.000276227 -
84_SER TYR gnomAD
chr10:76995102 		rs184626206
- 0.0015398 -
84_SER TYR 8.3kJPN
chr10:76995102 		rs184626206
- 0.0368 -
98_ALA GLY 8.3kJPN
chr10:76995060 		-
- 0.0001 -
116_SER PHE gnomAD
chr10:76994918 		rs372681735
- 0.00124296 -
116_SER PHE 8.3kJPN
chr10:76994918 		rs372681735
- 0.0027 -
128_GLY TRP gnomAD
chr10:76994883 		rs573613436
- 0.000437573 -
128_GLY TRP 8.3kJPN
chr10:76994883 		rs573613436
- 0.0015 -
129_ARG HIS 8.3kJPN
chr10:76994879 		-
- 0.0001 -
181_VAL MET gnomAD
chr10:76994463 		rs146747014
- 0.00012223 -
187_ASP ASN 8.3kJPN
chr10:76994445 		rs143196727
- 0.0001 -
193_ALA GLY 8.3kJPN
chr10:76994426 		-
- 0.0001 -
206_GLY SER 8.3kJPN
chr10:76994388 		rs1439517532
- 0.0001 -
216_ARG SER 8.3kJPN
chr10:76993974 		rs187820537
- 0.0002 -
224_LYS ASN gnomAD
chr10:76993948 		rs117429494
- 0.000175807 -
231_CYS PHE 8.3kJPN
chr10:76993928 		-
- 0.0001 -
236_ASN LYS gnomAD
chr10:76993912 		rs146844912
- 0.000127416 -
254_ASP GLU gnomAD
chr10:76993858 		rs550786448
- 0.000119351 -
258_LEU SER 8.3kJPN
chr10:76993847 		rs1239401988
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.