PDB ID 2C4J     CHAIN A
Protein name GLUTATHIONE S-TRANSFERASE MU 2
PDB 2C4J
The number of similar proteins 20
The number of binding states 2
The number of binding partners 1

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2C4J (CHAIN: A)
1 2C4J  
2 Monomeric state

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  1
  0

Sequence information

1   MPMTLGYWNI   RGLAHSIRLL   LEYTDSSYEE   KKYTMGDAPD   YDRSQWLNEK   50
51   FKLGLDFPNL   PYLIDGTHKI   TQSNAILRYI   ARKHNLCGES   EKEQIREDIL   100
101   ENQFMDSRMQ   LAKLCYDPDF   EKLKPEYLQA   LPEMLKLYSQ   FLGKQPWFLG   150
151   DKITFVDFIA   YDVLERNQVF   EPSCLDAFPN   LKDFISRFEG   LEKISAYMKS   200
201   SRFLPRPVFS   KMAVWGNK         250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
3_MET VAL 8.3kJPN
chr1:110199018 		rs1282403867
- 0.0001 -
6_GLY ARG 8.3kJPN
chr1:110199027 		-
- 0.0001 -
9_ASP GLU gnomAD
chr1:110230522 		rs184653774
- 0.000136455 -
12_GLY ARG 8.3kJPN
chr1:110230529 		-
- 0.0004 -
14_ALA VAL 8.3kJPN
chr1:110255244 		-
- 0.0001 -
15_HIS GLN gnomAD
chr1:110230800 		rs567320393
- 0.000920852 -
16_ALA VAL gnomAD
chr1:110230802 		rs536289169
- 0.000482946 -
17_ILE MET gnomAD
chr1:110199348 		rs148886417
- 0.00112532 -
18_ARG LEU gnomAD
chr1:110199350 		rs138088784
- 0.000111343 -
18_ARG HIS gnomAD
chr1:110211063 		rs145910843
- 0.00136 -
26_SER TER 8.3kJPN
chr1:110211087 		-
- 0.0001 -
26_SER LEU 8.3kJPN
chr1:110255280 		-
- 0.0001 -
30_GLU LYS 8.3kJPN
chr1:110230843 		rs1259669984
- 0.0001 -
32_LYS TER 8.3kJPN
chr1:110211104 		rs556730458
- 0.0002 -
34_THR ALA gnomAD
chr1:110211110 		rs755629589
- 0.000115318 -
34_THR ALA 8.3kJPN
chr1:110211110 		rs755629589
- 0.0011 -
34_THR MET 8.3kJPN
chr1:110255304 		rs540779576
- 0.0002 -
40_ASP TYR 8.3kJPN
chr1:110211552 		-
- 0.0001 -
59_ASN SER 8.3kJPN
chr1:110211610 		rs371911407
- 0.0084 -
64_ILE MET gnomAD
chr1:110256120 		rs142675425
- 0.000425454 -
65_ASP ASN 8.3kJPN
chr1:110256121 		-
- 0.0001 -
67_THR ALA gnomAD
chr1:110211933 		rs2227960
- 0.00151891 -
67_ALA THR gnomAD
chr1:110256127 		rs17854972
- 0.0830589 -
67_ALA THR 8.3kJPN
chr1:110256127 		rs17854972
- 0.0002 -
77_LEU PRO 8.3kJPN
chr1:110256158 		rs1360731264
- 0.0001 -
78_CYS ARG gnomAD
chr1:110200266 		rs145858198
- 0.000107358 -
78_ARG CYS gnomAD
chr1:110256160 		rs147739570
- 0.000127244 -
78_CYS ARG 8.3kJPN
chr1:110200266 		rs145858198
- 0.0001 -
78_CYS TRP 8.3kJPN
chr1:110200268 		rs1314408786
- 0.0001 -
78_ARG CYS 8.3kJPN
chr1:110256160 		rs147739570
- 0.0001 -
82_ARG CYS gnomAD
chr1:110231736 		rs781451004
- 0.000679769 -
82_ARG CYS 8.3kJPN
chr1:110200278 		rs201193976
- 0.0001 -
82_ARG HIS 8.3kJPN
chr1:110200279 		rs750577198
- 0.0014 -
82_ARG HIS 8.3kJPN
chr1:110211979 		rs769666982
- 0.0003 -
85_ASN SER gnomAD
chr1:110231746 		rs147668562
- 0.0381248 -
85_ASN LYS gnomAD
chr1:110231747 		rs146668816
- 0.000219242 -
96_ARG PRO gnomAD
chr1:110212120 		rs140675803
- 0.000174978 -
96_ARG CYS 8.3kJPN
chr1:110200420 		rs761147429
- 0.0001 -
96_ARG PRO 8.3kJPN
chr1:110212120 		rs140675803
- 0.0005 -
96_ARG LEU 8.3kJPN
chr1:110231874 		rs199816990
- 0.013 -
96_ARG LEU 8.3kJPN
chr1:110256310 		rs148956224
- 0.0071 -
97_VAL MET 8.3kJPN
chr1:110200423 		-
- 0.0001 -
104_VAL ILE 8.3kJPN
chr1:110256333 		rs756521706
- 0.0002 -
104_VAL ALA 8.3kJPN
chr1:110256334 		rs766842191
- 0.0002 -
105_MET THR 8.3kJPN
chr1:110231901 		rs202002774
- 0.0187 -
105_MET THR 8.3kJPN
chr1:110256337 		rs1326916949
- 0.0002 -
106_ASP GLU 8.3kJPN
chr1:110212151 		-
- 0.0001 -
107_ASN LYS gnomAD
chr1:110256344 		rs144915668
- 0.000107421 -
110_GLN TER 8.3kJPN
chr1:110200462 		rs1223667143
- 0.0001 -
111_LEU VAL 8.3kJPN
chr1:110256354 		-
- 0.0001 -
112_GLY VAL 8.3kJPN
chr1:110231922 		rs1179816349
- 0.0129 -
114_LEU GLN gnomAD
chr1:110256364 		rs144530836
- 0.00100068 -
115_CYS TYR gnomAD
chr1:110200478 		rs557974260
- 0.000111344 -
115_CYS TYR 8.3kJPN
chr1:110200478 		rs557974260
- 0.0007 -
116_TYR HIS gnomAD
chr1:110200480 		rs576929306
- 0.000170989 -
117_ASN HIS 8.3kJPN
chr1:110231936 		rs1363667431
- 0.0108 -
139_SER LEU 8.3kJPN
chr1:110257624 		-
- 0.0001 -
140_GLN TER 8.3kJPN
chr1:110201493 		-
- 0.0001 -
145_ARG TRP gnomAD
chr1:110232965 		rs142484086
- 0.0015642 -
145_ARG TRP gnomAD
chr1:110257641 		rs140499099
- 0.00949151 -
145_ARG TRP 8.3kJPN
chr1:110232965 		rs142484086
- 0.0003 -
145_ARG TRP 8.3kJPN
chr1:110257641 		rs140499099
- 0.0075 -
147_TRP ARG gnomAD
chr1:110257647 		rs150881777
- 0.00026244 -
147_TRP TER 8.3kJPN
chr1:110213989 		-
- 0.0001 -
149_LEU ILE 8.3kJPN
chr1:110213993 		-
- 0.0014 -
150_GLY GLU gnomAD
chr1:110201524 		rs760050912
- 0.000111335 -
150_GLY ARG 8.3kJPN
chr1:110201523 		rs776935872
- 0.0001 -
150_GLY GLU 8.3kJPN
chr1:110201524 		rs760050912
- 0.0001 -
151_ASN ASP gnomAD
chr1:110232983 		rs140584594
- 0.00174608 -
152_LYS GLU 8.3kJPN
chr1:110257662 		rs778331898
- 0.0011 -
159_LEU VAL gnomAD
chr1:110233094 		rs138440339
- 0.00031646 -
160_ALA THR gnomAD
chr1:110201643 		rs147618175
- 0.000218691 -
162_ASP VAL gnomAD
chr1:110233104 		rs544766466
- 0.000483405 -
164_LEU ARG 8.3kJPN
chr1:110257786 		-
- 0.0001 -
166_LEU ILE gnomAD
chr1:110233115 		rs149344762
- 0.0143247 -
167_HIS ASN gnomAD
chr1:110233118 		rs146001438
- 0.0154707 -
167_HIS GLN gnomAD
chr1:110233120 		rs143315534
- 0.0188043 -
168_ARG CYS gnomAD
chr1:110201667 		rs114328674
- 0.00109346 -
168_ARG CYS gnomAD
chr1:110233121 		rs375154572
- 0.000186931 -
168_ARG CYS 8.3kJPN
chr1:110257797 		rs761981861
- 0.0017 -
173_ASN LYS gnomAD
chr1:110201684 		rs147265487
- 0.000238572 -
173_LYS ASN gnomAD
chr1:110233138 		rs1065411
- 0.361675 -
173_LYS ASN gnomAD
chr1:110257814 		rs78955679
- 0.00598021 -
173_SER ASN 8.3kJPN
chr1:110214156 		rs2229050
- 0.0001 -
173_LYS ARG 8.3kJPN
chr1:110233137 		rs769295127
- 0.0005 -
173_LYS ASN 8.3kJPN
chr1:110233138 		rs1065411
- 0.7472 -
173_LYS ASN 8.3kJPN
chr1:110257814 		rs78955679
- 0.0743 -
177_ALA VAL gnomAD
chr1:110257825 		rs376313197
- 0.000119296 -
179_LEU PRO gnomAD
chr1:110257831 		rs2227963
- 0.0873792 -
181_LEU VAL 8.3kJPN
chr1:110214179 		-
- 0.0001 -
184_PHE LEU 8.3kJPN
chr1:110214190 		rs1557958959
- 0.0001 -
186_SER PHE 8.3kJPN
chr1:110214195 		-
- 0.0001 -
187_ARG HIS gnomAD
chr1:110233179 		rs753904217
- 0.000192694 -
187_ARG CYS gnomAD
chr1:110257854 		rs150417585
- 0.00560247 -
187_ARG HIS gnomAD
chr1:110257855 		rs137869431
- 0.000159048 -
202_ARG CYS gnomAD
chr1:110203823 		rs150650325
- 0.00043381 -
202_ARG HIS 8.3kJPN
chr1:110235865 		rs371247780
- 0.0001 -
205_ARG TER 8.3kJPN
chr1:110260004 		rs181150599
- 0.0012 -
206_ARG LYS 8.3kJPN
chr1:110217418 		rs527715023
- 0.0005 -
210_SER THR 8.3kJPN
chr1:110235888 		rs449856
- 0.0029 -
211_LYS ARG 8.3kJPN
chr1:110260023 		-
- 0.0001 -
212_VAL MET gnomAD
chr1:110203853 		rs149370166
- 0.0011034 -
213_ALA VAL gnomAD
chr1:110217439 		rs201667505
- 0.000139172 -
217_SER GLY gnomAD
chr1:110260040 		rs113130058
- 0.00813648 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.