PDB ID 2OK5 CHAIN A
Protein name Complement factor B
Uniprot Accession P00751
The number of similar proteins 5
The number of binding states 4
The number of binding partners 4
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
2OK5 (CHAIN: A)
1 Monomeric state
2 P01024   P01024  
3 Q91132   Q91132  

Q91132  
4 P01024   P01024  

P00746  
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partners
  2
  1
  0
Sequence information
1   GSHHHHHHGS   TPWSLARPQG   SCSLEGVEIK   GGSFRLLQEG   QALEYVCPSG   50
51   FYPYPVQTRT   CRSTGSWSTL   KTQDQKTVRK   AECRAIHCPR   PHDFENGEYW   100
101   PRSPYYNVSD   EISFHCYDGY   TLRGSANRTC   QVNGRWSGQT   AICDNGAGYC   150
151   SNPGIPIGTR   KVGSQYRLED   SVTYHCSRGL   TLRGSQRRTC   QEGGSWSGTE   200
201   PSCQDSFMYD   TPQEVAEAFL   SSLTETIEGV   DAEDGHGPGE   QQKRKIVLDP   250
251   SGSMNIYLVL   DGSDSIGASN   FTGAKKCLVN   LIEKVASYGV   KPRYGLVTYA   300
301   TYPKIWVKVS   EADSSNADWV   TKQLNEINYE   DHKLKSGTNT   KKALQAVYSM   350
351   MSWPDDVPPE   GWNRTRHVII   LMTDGLHNMG   GDPITVIDEI   RDLLYIGKDR   400
401   KNPREDYLDV   YVFGVGPLVN   QVNINALASK   KDNEQHVFKV   KDMENLEDVF   450
451   YQMIDESQSL   SLCGMVWEHR   KGTDYHKQPW   QAKISVIRPS   KGHESCMGAV   500
501   VSEYFVLTAA   HCFTVDDKEH   SIKVSVGGEK   RDLEIEVVLF   HPNYNINGKK   550
551   EAGIPEFYDY   DVALIKLKNK   LKYGQTIRPI   CLPCTEGTTR   ALRLPPTTTC   600
601   QQQKEELLPA   QDIKALFVSE   EEKKLTRKEV   YIKNGDKKGS   CERDAQYAPG   650
651   YDKVKDISEV   VTPRFLCTGG   VSPYADPNTC   RGDSGGPLIV   HKRSRFIQVG   700
701   VISWGVVDVC   KNQKRQKQVP   AHARDFHINL   FQVLPWLKEK   LQDEDLGFLA   750
751   AA           800
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
141_SER PRO VAR_063659 - Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
178_ARG GLN VAR_063660 rs745794224 Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
217_ILE LEU VAR_063661 rs144812066 Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
261_PHE LEU VAR_063221 rs117905900 Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
298_LYS GLU VAR_063222 rs121909748 Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
298_LYS GLN VAR_063662 - Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
433_MET ILE VAR_063663 rs200837114 Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
508_LYS ARG VAR_063664 rs149101394 Disease Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
540_LYS GLU VAR_016277 rs4151659 Polymorphism -
626_ASP GLU VAR_016278 rs4151660 Polymorphism -
711_ALA SER VAR_006495 - Polymorphism -