PDB ID 2WII CHAIN A
Protein name COMPLEMENT C3 BETA CHAIN
Uniprot Accession P01024
The number of similar proteins 25
The number of binding states 10
The number of binding partners 11
Coloring
Unicolor (beige)
The number of binding partners
Group

Downdload
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Molecule viewer
#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0
Sequence information
1   SPMYSIITPN   ILRLESEETM   VLEAHDAQGD   VPVTVTVHDF   PGKKLVLSSE   50
51   KTVLTPATNH   MGNVTFTIPA   NREFKSEKGR   NKFVTVQATF   GTQVVEKVVL   100
101   VSLQSGYLFI   QTDKTIYTPG   STVLYRIFTV   NHKLLPVGRT   VMVNIENPEG   150
151   IPVKQDSLSS   QNQLGVLPLS   WDIPELVNMG   QWKIRAYYEN   SPQQVFSTEF   200
201   EVKEYVLPSF   EVIVEPTEKF   YYIYNEKGLE   VTITARFLYG   KKVEGTAFVI   250
251   FGIQDGEQRI   SLPESLKRIP   IEDGSGEVVL   SRKVLLDGVQ   NPRAEDLVGK   300
301   SLYVSATVIL   HSGSDMVQAE   RSGIPIVTSP   YQIHFTKTPK   YFKPGMPFDL   350
351   MVFVTNPDGS   PAYRVPVAVQ   GEDTVQSLTQ   GDGVAKLSIN   THPSQKPLSI   400
401   TVRTKKQELS   EAEQATRTMQ   ALPYSTVGNS   NNYLHLSVLR   TELRPGETLN   450
451   VNFLLRMDRA   HEAKIRYYTY   LIMNKGRLLK   AGRQVREPGQ   DLVVLPLSIT   500
501   TDFIPSFRLV   AYYTLIGASG   QREVVADSVW   VDVKDSCVGS   LVVKSGQSED   550
551   RQPVPGQQMT   LKIEGDHGAR   VVLVAVDKGV   FVLNKKNKLT   QSKIWDVVEK   600
601   ADIGCTPGSG   KDYAGVFSDA   GLTFTSSSGQ   QTAQRAELQC   PQPAA   650
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
43_LYS GLN ClinVar
chr19:6719296
rs539992721 Likely pathogenic not provided [MedGen:CN517202]
80_ARG GLY VAR_001983 rs2230199 Polymorphism -
133_LYS GLN VAR_070941 rs147859257 Disease Macular degeneration, age-related, 9 (ARMD9) [MIM:611378]
192_PRO SER ClinVar
chr19:6714219
rs794729228 Likely pathogenic Atypical hemolytic-uremic syndrome 5 [MedGen:C2752037,OMIM:612925,Orphanet:ORPHA93575]
292_PRO LEU VAR_001984 rs1047286 Polymorphism -
447_GLU ASP VAR_020262 rs11569422 Polymorphism -
527_ASP ASN VAR_001985 rs1449441916 Disease Complement component 3 deficiency (C3D) [MIM:613779]
570_ARG GLN VAR_063213 rs121909583 Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
570_ARG TRP VAR_063214 rs771353792 Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]
581_PHE VAL VAR_063654 - Disease Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]