PiSITE

PDB ID	2XND	CHAIN	J
Protein name	ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL
Uniprot Accession	P32876
The number of similar proteins	8
The number of binding states	5
The number of binding partners	4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	2XND (CHAIN: J)
1	P32876 P32876 P05631
2	P32876 P32876
3	P32876 P32876 P05632
4	P32876 P32876 P05630
5	P32876 P32876 P05630 P05631

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Molecule viewer

Only interaction residues

#binding
partners

	1
	0

Sequence information

1

IDTAAKFIGA

GAATVGVAGS

GAGIGTVFGS

LIIGYARNPS

LKQQLFSYAI

50

51

LGFALSEAMG

LFCLMVAFLI

LF

100

Variants

	Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
	6_ALA	THR	8.3kJPN chr12:54063029	-	-	0.0005	-
	12_GLY	VAL	ClinVar chr2:176043863	-	Pathogenic	-	Dystonia, early-onset, and/or spastic paraplegia [MONDO:MONDO:0859215,MedGen:C5562051,OMIM:619681]
	14_ALA	PRO	8.3kJPN chr17:46972623	-	-	0.0001	-
	28_VAL	ALA	8.3kJPN chr17:46972666	rs1483214161	-	0.0001	-
	39_ASN	LYS	ClinVar chr2:176043127	rs757411192	Likely pathogenic	-	ATP5G3-associated disorder\|Dystonia, early-onset, and/or spastic paraplegia [\|MONDO:MONDO:0859215,MedGen:C5562051,OMIM:619681]
	40_PRO	ALA	ClinVar chr2:176043126	-	Pathogenic	-	Dystonia, early-onset, and/or spastic paraplegia [MONDO:MONDO:0859215,MedGen:C5562051,OMIM:619681]
	41_SER	PRO	gnomAD chr17:46973024	rs145199121	-	0.000139274	-
	42_LEU	PHE	8.3kJPN chr17:46973027	-	-	0.0001	-
	50_ALA	THR	8.3kJPN chr12:54059178	rs374457649	-	0.0001	-
	56_LEU	PHE	8.3kJPN chr12:54059160	-	-	0.0001	-
	68_ALA	VAL	8.3kJPN chr2:176043041	-	-	0.0001	-
	68_ALA	THR	8.3kJPN chr17:46973105	rs753944444	-	0.0001	-
	70_LEU	PRO	8.3kJPN chr12:54059117	-	-	0.0001	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364