PDB ID 3E7A CHAIN A
Protein name Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Uniprot Accession P62136
The number of similar proteins 34
The number of binding states 12
The number of binding partners 9
Coloring
Unicolor (beige)
The number of binding partners
Group

Binding
state
Binding partners
Downdload
 Format:  
Molecule viewer
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0
Sequence information
1   GHMGSLNLDS   IIGRLLEVQG   SRPGKNVQLT   ENEIRGLCLK   SREIFLSQPI   50
51   LLELEAPLKI   CGDIHGQYYD   LLRLFEYGGF   PPESNYLFLG   DYVDRGKQSL   100
101   ETICLLLAYK   IKYPENFFLL   RGNHECASIN   RIYGFYDECK   RRYNIKLWKT   150
151   FTDCFNCLPI   AAIVDEKIFC   CHGGLSPDLQ   SMEQIRRIMR   PTDVPDQGLL   200
201   CDLLWSDPDK   DVQGWGENDR   GVSFTFGAEV   VAKFLHKHDL   DLICRAHQVV   250
251   EDGYEFFAKR   QLVTLFSAPN   YCGEFDNAGA   MMSVDETLMC   SFQILKPAD   300
Variants
Residue AA Source dbSNP Clinical
Significance
Disease name
50_PRO ARG ClinVar
chr2:28999810
rs886037952 Pathogenic Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
57_ALA PRO ClinVar
chr2:28999830
rs1114167429 Pathogenic Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]
86_ASN LYS ClinVar
chr2:29001745
rs1553310744 Likely pathogenic not provided [MedGen:CN517202]
184_GLU ALA ClinVar
chr2:29006800
rs886037954 Pathogenic Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
184_GLU VAL ClinVar
chr2:29006800
rs886037954 Pathogenic Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]
221_ARG CYS ClinVar
chr2:29011589
rs1553311527 Likely pathogenic not provided [MedGen:CN517202]
253_ASP TYR ClinVar
chr2:29016738
rs886037953 Likely pathogenic not provided [MedGen:CN517202]
275_GLU LYS ClinVar
chr2:29016804
rs886037955 Likely pathogenic Noonan syndrome-like disorder with loose anagen hair 2 [MedGen:C4479577,OMIM:617506]; not provided [MedGen:CN517202]