PDB ID 3QD6     CHAIN R
Protein name Tumor necrosis factor receptor superfamily member 5
Uniprot Accession P25942
The number of similar proteins 8
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3QD6 (CHAIN: R)
1 P29965   P29965  
2 7P3I  
3 5DMJ  
4 6PE8   6PE8  
5 6FAX   6FAX  

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Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   EPPTACREKQ   YLINSQCCSL   CQPGQKLVSD   CTEFTETECL   PCGESEFLDT   50
51   WNRETHCHQH   KYCDPNLGLR   VQQKGTSETD   TICTCEEGWH   CTSEACESCV   100
101   LHRSCSPGFG   VKQIATGVSD   TICEPCPVGF   FSNVSSAFEK   CHPWTSCETK   150
151   DLVVQQAGTN   KTDVVCGPQD   SGRLVPR       200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
26_CYS GLN VAR_039301 -
US - Bladder carcinoma cell line Hu549
35_SER GLY VAR_039302 rs750234130
US - Bladder carcinoma cell line Hu549
37_CYS GLY VAR_077569 -
LP/P - Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]
39_SER THR VAR_039303 -
US - Bladder carcinoma cell line Hu549
53_GLU TER ClinVar
chr20:44750898 		-
Pathogenic - not provided [MedGen:C3661900]
83_CYS ARG VAR_013628 rs28931586
LP/P - Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]
83_CYS ARG ClinVar
chr20:44750988 		rs28931586
Pathogenic - Hyper-IgM syndrome type 3 [MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090]
90_ARG GLN gnomAD
chr20:44751261 		rs761229326
- 0.000143181 -
90_ARG GLN 8.3kJPN
chr20:44751261 		rs761229326
- 0.0001 -
102_ILE MET 8.3kJPN
chr20:44751298 		-
- 0.0001 -
124_SER LEU VAR_018751 rs11569321
LB/B - -
124_SER LEU gnomAD
chr20:44751363 		rs11569321
- 0.0104388 -
134_ILE PHE 8.3kJPN
chr20:44751392 		-
- 0.0001 -
136_THR THR ClinVar
chr20:44751769 		rs2145595063
Pathogenic - Hyper-IgM syndrome type 3 [MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.