PDB ID 3UTM     CHAIN A
Protein name Tankyrase-1
Uniprot Accession Q6PFX9
The number of similar proteins 7
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3UTM (CHAIN: A)
1 Q6PFX9   O35625  
2 Q6PFX9  
3 O60829  
4 Q6PFX9   P54274  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GEFGKSALDL   ADPSAKAVLT   GEYKKDELLE   AARSGNEEKL   MALLTPLNVN   50
51   CHASDGRKST   PLHLAAGYNR   VRIVQLLLQH   GADVHAKDKG   GLVPLHNACS   100
101   YGHYEVTELL   LKHGACVNAM   DLWQFTPLHE   AASKNRVEVC   SLLLSHGADP   150
151   TLVNCHGKSA   VDMAPTPELR   ERLTYEFKGH   SLLQAAREAD   LAKVKKTLAL   200
201   EIINFKQPQS   HETALHCAVA   SLHPKRKQVA   ELLLRKGANV   NEKNKDFMTP   250
251   LHVAAERAHN   DVMEVLHKHG   AKMNALDSLG   QTALHRAALA   GHLQTCRLLL   300
301   SYGSDPSIIS   LQGFTAAQMG   NEAVQQILSE   STPMRTSDVD   YRLLEASKAG   350
351   D           400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
332_LEU VAL 8.3kJPN
chr8:9537481 		-
- 0.0001 -
336_ALA SER 8.3kJPN
chr10:93579059 		-
- 0.0001 -
355_CYS PHE 8.3kJPN
chr8:9538288 		rs777564565
- 0.0001 -
380_LEU PHE 8.3kJPN
chr8:9562224 		-
- 0.0001 -
390_ALA GLY 8.3kJPN
chr10:93579778 		-
- 0.0002 -
411_THR ALA gnomAD
chr10:93582102 		rs200360192
- 0.000266599 -
431_PRO SER 8.3kJPN
chr10:93586816 		-
- 0.0001 -
480_GLU ASP 8.3kJPN
chr10:93588046 		-
- 0.0001 -
493_ALA THR 8.3kJPN
chr8:9565922 		-
- 0.0001 -
497_ARG GLN 8.3kJPN
chr10:93588096 		rs765942229
- 0.0001 -
525_SER CYS 8.3kJPN
chr8:9567481 		rs1416500888
- 0.0002 -
531_LYS TER 8.3kJPN
chr10:93590713 		-
- 0.0001 -
573_HIS LEU 8.3kJPN
chr8:9567720 		-
- 0.0001 -
583_LEU PHE gnomAD
chr10:93593628 		rs41286934
- 0.000726967 -
584_GLY ARG 8.3kJPN
chr8:9577905 		rs1488582270
- 0.0001 -
599_THR ILE 8.3kJPN
chr8:9577951 		rs1325546478
- 0.0001 -
611_SER CYS 8.3kJPN
chr8:9577987 		-
- 0.0002 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.