PDB ID 4WJG     CHAIN C
Protein name Haptoglobin
Uniprot Accession P00738
The number of similar proteins 5
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4WJG (CHAIN: C)
1 P00738   I7BA80   P69905   P68871  
2 P69905   P68871  
3 I7B1A7   P69905   P68871  
4 P68871   P69905   A0A0E8IWL6  

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Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   CPKPPEIAHG   YVEHSVRYQC   KNYYKLRTEG   DGVYTLNNEK   QWINKAVGDK   50
51   LPECEAVCGK   PKNPANPVQR   ILGGHLDAKG   SFPWQAKMVS   HHNLTTGATL   100
101   INEQWLLTTA   KNLFLNHSEN   ATAKDIAPTL   TLYVGKKQLV   EIEKVVLHPN   150
151   YSQVDIGLIK   LKQKVSVNER   VMPICLPSKD   YAEVGRVGYV   SGWGRNANFK   200
201   FTDHLKYVML   PVADQDQCIR   HYEGSTVPEK   KTPKSPVGVQ   PILNEHTFCA   250
251   GMSKYQEDTC   YGDAGSAFAV   HDLEEDTWYA   TGILSFDKSC   AVAEYGVYVK   300
301   VTSIQDWVQK   TIAEN         350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
96_PRO LEU gnomAD
chr16:72090450 		rs371786946
- 0.000256279 -
97_GLU LYS gnomAD
chr16:72090452 		rs201773535
- 0.00296035 -
98_ILE THR gnomAD
chr16:72108210 		rs201044200
- 0.00016029 -
100_ASN HIS 8.3kJPN
chr16:72108215 		rs152832
- 0.0001 -
101_GLY CYS gnomAD
chr16:72108218 		rs763666282
- 0.000112197 -
112_LYS GLU 8.3kJPN
chr16:72092221 		rs1197605628
- 0.0024 -
116_ARG THR gnomAD
chr16:72108264 		rs152833
- 0.000749337 -
117_LEU ARG 8.3kJPN
chr16:72092237 		-
- 0.0001 -
118_ARG HIS gnomAD
chr16:72090516 		rs751924863
- 0.000154211 -
118_ARG CYS gnomAD
chr16:72108269 		rs368767302
- 0.000116206 -
118_ARG HIS 8.3kJPN
chr16:72092240 		rs768960704
- 0.0009 -
118_ARG CYS 8.3kJPN
chr16:72108269 		rs368767302
- 0.0001 -
124_VAL MET 8.3kJPN
chr16:72093015 		-
- 0.0001 -
129_ASN ASP VAR_005294 rs199926732
LB/B - -
129_ASN ASP gnomAD
chr16:72093030 		rs199926732
- 0.000264053 -
129_ASN ASP 8.3kJPN
chr16:72093030 		rs199926732
- 0.0001 -
130_GLU LYS VAR_017113 rs200877317
LB/B - -
130_GLU LYS gnomAD
chr16:72093033 		rs200877317
- 0.000305112 -
130_GLU LYS 8.3kJPN
chr16:72093033 		rs200877317
- 0.0001 -
133_TRP ARG 8.3kJPN
chr16:72109073 		-
- 0.0002 -
147_ALA GLY 8.3kJPN
chr16:72109116 		-
- 0.0001 -
151_LYS MET 8.3kJPN
chr16:72110211 		-
- 0.0001 -
153_LYS GLU 8.3kJPN
chr16:72110216 		-
- 0.0001 -
155_PRO ARG gnomAD
chr16:72094032 		rs562787662
- 0.000145127 -
155_PRO LEU 8.3kJPN
chr16:72094032 		rs562787662
- 0.0001 -
162_HIS GLN gnomAD
chr16:72110257 		rs201615147
- 0.000375309 -
162_HIS GLN 8.3kJPN
chr16:72110257 		rs201615147
- 0.0198 -
171_TRP TER 8.3kJPN
chr16:72110283 		rs531532112
- 0.0008 -
176_VAL PHE 8.3kJPN
chr16:72094106 		-
- 0.0001 -
210_ALA VAL gnomAD
chr16:72110400 		rs1049933
- 0.00854869 -
213_ILE THR gnomAD
chr16:72110409 		rs200632830
- 0.00050146 -
213_ILE THR 8.3kJPN
chr16:72110409 		rs200632830
- 0.0001 -
232_VAL ALA gnomAD
chr16:72094275 		rs375993947
- 0.00011226 -
236_PRO LEU 8.3kJPN
chr16:72110478 		rs757811087
- 0.0001 -
239_HIS TYR gnomAD
chr16:72110486 		rs574707341
- 0.000168384 -
239_HIS PRO gnomAD
chr16:72110487 		rs675948
- 0.000172383 -
239_HIS TYR 8.3kJPN
chr16:72110486 		rs574707341
- 0.0147 -
239_HIS PRO 8.3kJPN
chr16:72110487 		rs675948
- 0.0147 -
242_ASP GLY 8.3kJPN
chr16:72110496 		-
- 0.0001 -
243_ILE THR VAR_066214 rs104894517
LP/P - Anhaptoglobinemia (AHP) [MIM:614081]
243_ILE THR gnomAD
chr16:72110499 		rs199591333
- 0.000132315 -
245_LEU PRO 8.3kJPN
chr16:72110505 		-
- 0.001 -
253_LEU PHE gnomAD
chr16:72110528 		rs200495504
- 0.000637361 -
253_LEU PRO gnomAD
chr16:72110529 		rs201896057
- 0.000637336 -
253_LEU PHE 8.3kJPN
chr16:72110528 		rs200495504
- 0.0049 -
253_LEU PRO 8.3kJPN
chr16:72110529 		rs201896057
- 0.0049 -
257_ARG LYS gnomAD
chr16:72110541 		rs2021171
- 0.0411582 -
257_ARG LYS 8.3kJPN
chr16:72110541 		rs2021171
- 0.0482 -
259_MET LYS 8.3kJPN
chr16:72110547 		-
- 0.0001 -
264_PRO THR 8.3kJPN
chr16:72110561 		-
- 0.0001 -
267_ASN ASP gnomAD
chr16:72110570 		rs375115348
- 0.000124254 -
267_ASP ASN 8.3kJPN
chr16:72094379 		rs189039907
- 0.0001 -
273_ARG HIS gnomAD
chr16:72094398 		rs200200966
- 0.000152339 -
273_ARG HIS gnomAD
chr16:72110589 		rs144648182
- 0.00123846 -
273_ARG CYS 8.3kJPN
chr16:72094397 		rs760921268
- 0.0001 -
273_ARG HIS 8.3kJPN
chr16:72094398 		rs200200966
- 0.0001 -
273_ARG CYS 8.3kJPN
chr16:72110588 		rs762990031
- 0.0001 -
273_ARG HIS 8.3kJPN
chr16:72110589 		rs144648182
- 0.0092 -
282_ARG GLN gnomAD
chr16:72094425 		rs201130844
- 0.00026073 -
282_ARG PRO 8.3kJPN
chr16:72094425 		rs201130844
- 0.0007 -
288_PHE LEU 8.3kJPN
chr16:72094442 		rs769601309
- 0.0011 -
289_THR ASN gnomAD
chr16:72110637 		rs147899609
- 0.00603709 -
300_ALA ASP 8.3kJPN
chr16:72110670 		-
- 0.0001 -
304_GLN HIS 8.3kJPN
chr16:72094492 		rs538293575
- 0.0001 -
307_THR MET 8.3kJPN
chr16:72110691 		rs764873631
- 0.0001 -
308_HIS ARG gnomAD
chr16:72110694 		rs763626797
- 0.000328752 -
308_HIS GLN gnomAD
chr16:72110695 		rs201323582
- 0.000140318 -
311_GLY ASP 8.3kJPN
chr16:72110703 		rs201744401
- 0.0001 -
313_THR PRO 8.3kJPN
chr16:72110708 		-
- 0.0001 -
316_GLU LYS 8.3kJPN
chr16:72094526 		rs779931784
- 0.0001 -
316_LYS ASN 8.3kJPN
chr16:72110719 		-
- 0.0001 -
330_LEU PRO 8.3kJPN
chr16:72110760 		-
- 0.0001 -
337_VAL ALA gnomAD
chr16:72110781 		rs1065360
- 0.0414842 -
337_VAL ALA 8.3kJPN
chr16:72110781 		rs1065360
- 0.0483 -
338_GLY SER gnomAD
chr16:72110783 		rs201688913
- 0.000240487 -
340_SER CYS 8.3kJPN
chr16:72110790 		rs746207251
- 0.0026 -
351_ALA VAL gnomAD
chr16:72110823 		rs368733337
- 0.000104193 -
351_ALA VAL 8.3kJPN
chr16:72110823 		rs368733337
- 0.0006 -
352_GLY ASP gnomAD
chr16:72110826 		rs374535436
- 0.000144259 -
368_THR ALA gnomAD
chr16:72094682 		rs470428
- 0.000276586 -
368_ALA THR gnomAD
chr16:72110873 		rs149194838
- 0.000120212 -
368_THR ALA 8.3kJPN
chr16:72094682 		rs470428
- 0.0004 -
368_THR ILE 8.3kJPN
chr16:72094683 		-
- 0.0001 -
384_VAL GLU 8.3kJPN
chr16:72110922 		rs1257568574
- 0.0001 -
392_GLN ARG 8.3kJPN
chr16:72110946 		rs151331078
- 0.0007 -
393_ASP HIS VAR_017114 rs189115161
LB/B - -
393_ASP HIS gnomAD
chr16:72094757 		rs189115161
- 0.00121485 -
393_HIS ASP gnomAD
chr16:72110948 		rs12646
- 0.355901 -
393_ASP HIS 8.3kJPN
chr16:72094757 		rs189115161
- 0.0003 -
393_HIS ASP 8.3kJPN
chr16:72110948 		rs12646
- 0.39 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.